Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract: A liquid formulation with uniform consistency over extended periods of time, said method comprising the steps of: providing a liquid formulation in a container, said liquid formulation having a viscosity greater than five centipoise; driving, by means of a power source, a piezoelectric actuator which is coupled to an orifice plate so that the piezoelectric actuator vibrates said plate to produce and disperse fine droplets of said liquid formulation, said plate being formed with orifices having diameters in the range of 1-25 microns; said piezoelectric actuator operating in a bending mode; and during vibration of said plate, delivering said liquid formulation from said container to said plate by capillary action.

Abstract: A delivery system and methods for generating droplets of liquid active materials, such as a perfume, air freshener, insecticide formulation, and volatile materials, to the atmosphere by means of a electromechanical transducer. The electromechanical transducer employs a first period of activation and a second period of deactivation to increase the distribution of volatile materials contained within the liquid active materials to the atmosphere and reduce the hedonic habituation of the user. The electromechanical transducer is configured to improve flow rate and decrease deposition of the droplets on to nearby surfaces.

Abstract: A delivery system or apparatus for the production, evaporation or release of volatile materials, wherein the volatile material contains a high level of solids to enhance intensity, character and/or substantivity of a perfume presentation or other fluid property. By providing a formulation with a relatively higher level of solids, an increase in intensity, perceived character and substantivity may be achieved. The system may be capable of battery operation and/or use an open capillary tube to deliver the volatile material from a reservoir to a transducer.