Abstract: A compliance/adherence management and automated data collection system uses a plurality of communications modalities implemented over wireless or wired communications systems for redundantly and persistently transmitting messages to and/or receiving messages from an end user for managing compliance/adherence of the end user concerning schedules and medication and treatment protocols. The system also uses wireless or wired communications modalities for automating real time collection of information from the end user concerning, for example, compliance with the schedule and/or protocol. The collected data can be remotely accessed, in real time, to monitor compliance/adherence and an end user's experiences resulting from compliance/adherence. Further, the management messages are so designed as to be highly personalized in order to achieve a more favorable response from the end user.