Patents by Inventor John Hermon-Taylor

John Hermon-Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8147850
    Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: April 3, 2012
    Assignee: HAV Vaccines Limited
    Inventors: John Hermon-Taylor, Timothy John Bull
  • Patent number: 8148136
    Abstract: This invention relates to the protein, Mycobacterium paratuberculosis acylase (mpa) and the gene encoding mpa, which we have identified in the pathogen Mycobacterium paratuberculosis Mptb (also designated Mycobacterium avium subspecies paratuberculosis MAP), and to their use in the diagnosis of Mptb/MAP infections in animals and humans, as well as their use as components of vaccines for the prevention and treatment of diseases caused by Mptb/MAP. The importance of an intact uninterrupted mpa gene as a determinant of pathogenicity in Mptb/MAP is recognized and the invention also provides attenuated strains of normally pathogenic Mptb/MAP and other mycobacteria in which mpa has been inactivated, for use as vaccines.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: April 3, 2012
    Assignee: HAV Vaccines Limited
    Inventors: John Hermon-Taylor, Timothy John Bull
  • Publication number: 20110129502
    Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.
    Type: Application
    Filed: January 14, 2011
    Publication date: June 2, 2011
    Applicant: HAV Vaccines Limited
    Inventors: John Hermon-Taylor, Timothy John Bull
  • Patent number: 7892566
    Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: February 22, 2011
    Assignee: HAV Vaccines Limited
    Inventors: John Hermon-Taylor, Timothy John Bull
  • Publication number: 20090203593
    Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.
    Type: Application
    Filed: August 3, 2006
    Publication date: August 13, 2009
    Applicant: St.Georges Enterprises Limited
    Inventors: John Hermon-Taylor, Timothy John Bull
  • Patent number: 7541181
    Abstract: The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: June 2, 2009
    Inventors: John Hermon-Taylor, Tim Doran, Douglas Millar, Mark Tizard, Mark Loughlin, Nazira Sumar, John Ford
  • Publication number: 20060204521
    Abstract: The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Applicant: St. George's Hospital Medical School
    Inventors: John Hermon-Taylor, Tim Doran, Douglas Millar, Mark Tizard, Mark Loughlin, Nazira Sumar, John Ford
  • Publication number: 20040260078
    Abstract: The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.
    Type: Application
    Filed: March 22, 2004
    Publication date: December 23, 2004
    Applicant: St. George's Hospital Medical School
    Inventors: John Hermon-Taylor, Tim Doran, Douglas Millar, Mark Tizard, Mark Loughlin, Nazira Sumar, John Ford
  • Patent number: 6156322
    Abstract: The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOs: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: December 5, 2000
    Assignee: St. George's Hospital Medical School
    Inventors: John Hermon-Taylor, Tim Doran, Douglas Millar, Mark Tizard, Mark Loughlin, Nazira Sumar, John Ford
  • Patent number: 5356781
    Abstract: Pancreatic disease can be diagnosed by assaying a patient's body fluid such as serum or urine, for pancreatic activation peptides (PAP) released from zymogens by proteolytic activation. Particularly useful are peptides having C-terminal D.sub.4 K sequences. The method uses polyclonal or monoclonal antibodies generated and selected for C-terminal specificity on PAP so that the tests only report free PAP not parent zymogen. Also described are peptides and antibodies labelled with revealing agents and/or immobilised on solid supports and their use in diagnostic assays and kits. In pancreatic disease the tests distinguish necrotising from oedematous acute pancreatitis and permit severity prediction and monitoring as well as diagnosing chronic pancreatitis in exacerbation.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: October 18, 1994
    Assignee: Bioscience International, Inc.
    Inventors: John Hermon-Taylor, Brian M. Austen
  • Patent number: 5225324
    Abstract: The invention relates to a family of DNA insertion sequences (ISMY) of mycobacterial origin and other DNA probes which may be used a probes in assay methods for the identification of mycobacteria and the differentiation between closely related mycobacterial strains and species. In one method the probes are used to distinguish pathogenic M. paratuberculosis from M. avium, which finds an application in the diagnosis of Crohn's disease in humans and Johne's disease in animals. The use of ISMY, and of proteins and peptides encoded by ISMY, in vaccines, pharmaceutical preparations and diagnostic test kits is also disclosed.
    Type: Grant
    Filed: April 14, 1992
    Date of Patent: July 6, 1993
    Assignee: Bioscience International, Inc.
    Inventors: John-Jo McFadden, John Hermon-Taylor
  • Patent number: 4948723
    Abstract: Pancreatic disease can be diagnosed by assaying a patient's body fluid, e.g. serum or urine, for the activation peptides of pancreatic zymogens specifically cleaved by proteolysis during activation, (PAP) e.g. peptides including the sequence D.sub.4 K having the lysine as the carboxy terminus. When PAP is assayed for, the test provides a means for distinguishing necrotising acute pancreatitis from oedematous acute pancreatitis, provides for diagnosis of chronic pancreatitis in exacerbation, and permits monitoring of the severity progress of the disease. Also described are antibodies having specificity for the pancreatic activation peptides, as well as such peptides and antibodies which are labelled with revealing agents and/or immobilized on solid supports, and their use in diagnostic test kits.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: August 14, 1990
    Assignee: Bioscience International, Inc.
    Inventors: John Hermon-Taylor, Brian M. Austen
  • Patent number: 4593018
    Abstract: Compounds of the general formula: ##STR1## wherein n is an integer from 2 to 6, m is an integer from 2 to 4, p is an integer from 1 to 3, R is H, an amino protecting group conventionally used in peptide chemistry or a solid phase support, R.sub.1 is H or a carboxy protecting group conventionally used in peptide chemistry and R.sub.2 is H or alkyl or H.sub.2 N--C.dbd.NH are useful for inhibiting the activity of enterokinases.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: June 3, 1986
    Assignee: National Research Development Corp.
    Inventors: Brian M. Austen, Steven Cliffe, David Grant, John Hermon-Taylor