Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a stepwise fashion, during the activation, the sources activated according to a pulse train, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: Accessory mounting rails having locating and clamping elements can be secured to the lower frame of a composite-framed pistol with uniform clamping force to prevent distortion of the lower frame and improve firearm operational reliability. Standard or custom accessory-mounting features may be provided in one or more locations above, below, and to the right and left sides of the pistol's barrel, allowing a number of accessories to be installed and operated together.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points being located along a common street segment. Accordingly, serviceable point data identifying corresponding street segment identifiers are stored for a plurality of serviceable points. Thereafter, shipping data for a first shipment to be delivered to a first serviceable point is received, and a determination is made whether a second shipment scheduled to be delivered to a second serviceable point is available for synchronized delivery with the first shipment. The determination comprises determining whether the street segment corresponding to the first serviceable point is the same as and/or is connected to the street segment corresponding to the second serviceable point.

Abstract: Systems, methods, and media are provided herein for synchronizing delivery between two or more shipments, each shipment associated with one or more items. For example, a Global Positioning System (GPS) device detects a geocode for a first serviceable point, the geocode corresponding to a latitude and longitude coordinate (and an altitude in some aspects). A record may be stored at a database, the record comprising shipment data for a shipment of an item and the geocode for the first serviceable point. Another shipment may be determined to be within a range of a time associated with the shipment data for the shipment. The other shipment may also have a second serviceable point within a threshold distance of the first serviceable point. Based on the range of time and the threshold distance, an indication (that the shipments are available for synchronized delivery) may be provided.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points being logically clustered. Accordingly, various embodiments store a record for a serviceable point comprising data identifying the serviceable point and data identifying a second serviceable point. Thereafter, shipping data for a first shipment to be delivered to the serviceable point is received, and the record for the serviceable point is accessed to retrieve the data identifying the second serviceable point. A second shipment scheduled to be delivered to the second serviceable point is identified, and an indication is provided that the first and second shipments are eligible for synchronized delivery.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points being associated with a common geographic descriptor. Accordingly, various embodiments receive shipping data for a first shipment to be delivered to a first serviceable point and a second shipment to be delivered to a second serviceable point. A first geographic descriptor is identified as associated with the first serviceable point and a second geographic descriptor is identified as associated with the second serviceable point, and a determination is made whether the first and second geographic descriptors are the same. Upon a determination that the first and second geographic descriptors are the same, an indication is provided that the first and second shipments are eligible for synchronized delivery.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points being located along a common street segment. Accordingly, serviceable point data identifying corresponding street segment identifiers are stored for a plurality of serviceable points. Thereafter, shipping data for a first shipment to be delivered to a first serviceable point is received, and a determination is made whether a second shipment scheduled to be delivered to a second serviceable point is available for synchronized delivery with the first shipment. The determination comprises determining whether the street segment corresponding to the first serviceable point is the same as and/or is connected to the street segment corresponding to the second serviceable point.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points being located along a common street segment. Accordingly, serviceable point data identifying corresponding street segment identifiers are stored for a plurality of serviceable points. Thereafter, shipping data for a first shipment to be delivered to a first serviceable point is received, and a determination is made whether a second shipment scheduled to be delivered to a second serviceable point is available for synchronized delivery with the first shipment. The determination comprises determining whether the street segment corresponding to the first serviceable point is the same as and/or is connected to the street segment corresponding to the second serviceable point.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points being located within a common geofenced area. Accordingly, a geofence is defined surrounding a geographical area comprising a plurality of serviceable points. The geofence is associated with a record for a serviceable point located within the geofenced area, wherein the record comprises a physical address and a geocode for the serviceable point. Thereafter, shipping data for a shipment to be delivered to the serviceable point is received, and is compared to a database of shipments to determine whether a second shipment is to be delivered to a second serviceable point located within the same geofenced area.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on a determination of distance between serviceable points and/or time required to travel between serviceable points. Accordingly, shipping data for a first shipment is initially received, and a determination is made whether a second shipment is available for synchronized delivery with the first shipment. To make such a determination, a previous distance is identified between a first serviceable point and a second serviceable point, a time elapsed is identified between the first serviceable point and the second serviceable point, and the distance and the time elapsed are compared with respective thresholds.

Abstract: Various embodiments provide systems and methods for facilitating synchronized delivery of shipments/items scheduled to be delivered to multiple serviceable points located nearby one another. Various embodiments identify nearby serviceable points based on an identification of serviceable points within a common delivery density area. In various embodiments, serviceable point data identifying a serviceable point cluster are stored for a plurality of serviceable points. Shipping data for a first shipment to be delivered to a first serviceable point is then received, and a determination is made whether a second shipment is scheduled to be delivered to a second serviceable point within the same cluster as the first serviceable point. Historical delivery activity is identified for the serviceable point cluster, and is compared with a threshold frequency.

Abstract: A chair with misting apparatus including a liquid dispenser assembly which provides a plurality of 360-degree adjustable nozzles disposed within the seat and backrest portions of the chair, each nozzle having a flow control switch connected to a tank mounted underneath the chair, the tank supplying liquid to the nozzles via conduit disposed within a channel in both the seat and backrest portions of the chair. Alternative embodiments of the apparatus include either an electric pump or a manual pump, and a non-foldable or foldable chair.

Abstract: In one embodiment, a method can include: (i) receiving a contact center interaction request via a device coupled to a display screen; (ii) accessing information about the device or a user of the device from a customer database of a content provider; and (iii) establishing an interaction path between the contact center and a viewer. The method can further include providing information to the user via the interaction path in response to a request by the user for the information. The device can be a set-top box (STB) or a cable card and the display screen can be a television, for example. Also, the content provider can be a cable or satellite television provider, for example.

Abstract: In one embodiment, a method can include: (i) receiving a contact center interaction request via a device coupled to a display screen; (ii) accessing information about the device or a user of the device from a customer database of a content provider; and (iii) establishing an interaction path between the contact center and a viewer. The method can further include providing information to the user via the interaction path in response to a request by the user for the information. The device can be a set-top box (STB) or a cable card and the display screen can be a television, for example. Also, the content provider can be a cable or satellite television provider, for example.

Abstract: This invention relates to the control of bindweed by applying to the locus of the bindweed a compound selected from compounds having the following formula: ##STR1## wherein R.sub.1 and R.sub.2 independently can be alkyl of 1 to 3 carbon atoms or allyl.

Abstract: This invention relates to a method of controlling bindweed by applying to the locus of the bindweed an effective amount of at least one compound of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms or allyl; and M is hydrogen, ammonium, sodium, lithium, or potassium.

Abstract: A disposable diaper comprising a waterproof back sheet, a hydrophobic sheet, and an hydrophilic pad sandwiched between the back sheet and the face sheet. The diaper is folded to define a box pleated configuration. Sealing strips of waterproof material separate from the back sheet are secured to the face sheet.

Abstract: A disposable diaper comprising a waterproof back sheet, a hydrophobic sheet, and an absorbent pad sandwiched between the back sheet and the face sheet. The diaper is folded to define a box pleated configuration having a central panel, inwardly extending panels and outwardly extending panels with the inner edges of the inwardly extending panels being in abutting relationship. Sealing strips of waterproof material separate from the back sheet are secured on the face sheet. The sealing strips are formed by folding an excess width of the back sheet over the face sheet forming side flap portions, and then cutting the side flap portions free from the back sheet. The sealing strips may be folded inwardly toward the center of the diaper to form fluid catching seals.