Abstract: A pattern stimulus system is described that includes a hemispherical concave surface, a plurality of illumination sources, and a controller. The illumination sources are arranged on the hemispherical concave surface in a plurality of annular rows and a plurality of radial columns. The control is configured to operate the illumination sources to display a checkerboard pattern by illuminating a first subset of the illumination sources and dimming a second subset of the illumination sources. The control is further configured to invert the checkerboard pattern by dimming the first subset of the illumination sources and illuminating the second subset of the illumination sources. Methods are also described for using the pattern stimulus system to evaluate a condition of the eye and to diagnose diseases of the eye.

Abstract: A pattern stimulus system is described that includes a hemispherical concave surface, a plurality of illumination sources, and a controller. The illumination sources are arranged on the hemispherical concave surface in a plurality of annular rows and a plurality of radial columns. The control is configured to operate the illumination sources to display a checkerboard pattern by illuminating a first subset of the illumination sources and dimming a second subset of the illumination sources. The control is further configured to invert the checkerboard pattern by dimming the first subset of the illumination sources and illuminating the second subset of the illumination sources. Methods are also described for using the pattern stimulus system to evaluate a condition of the eye and to diagnose diseases of the eye.

Abstract: A pattern stimulus system is described that includes a hemispherical concave surface, a plurality of illumination sources, and a controller. The illumination sources are arranged on the hemispherical concave surface in a plurality of annular rows and a plurality of radial columns. The control is configured to operate the illumination sources to display a checkerboard pattern by illuminating a first subset of the illumination sources and dimming a second subset of the illumination sources. The control is further configured to invert the checkerboard pattern by dimming the first subset of the illumination sources and illuminating the second subset of the illumination sources. Methods are also described for using the pattern stimulus system to evaluate a condition of the eye and to diagnose diseases of the eye.

Abstract: A pattern stimulus system is described that includes a hemispherical concave surface, a plurality of illumination sources, and a controller. The illumination sources are arranged on the hemispherical concave surface in a plurality of annular rows and a plurality of radial columns. The control is configured to operate the illumination sources to display a checkerboard pattern by illuminating a first subset of the illumination sources and dimming a second subset of the illumination sources. The control is further configured to invert the checkerboard pattern by dimming the first subset of the illumination sources and illuminating the second subset of the illumination sources. Methods are also described for using the pattern stimulus system to evaluate a condition of the eye and to diagnose diseases of the eye.

Abstract: The present invention provides an electrode array device for simultaneously detecting electrical potentials at five or more locations on the anterior surface of an eye. The device comprises a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye, and at least five recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the eye when the lens substrate is placed on the anterior surface of eye. Each recording electrode is in electrically conductive communication with a corresponding conductive contact, there being one conductive contact for each recording electrode. Each conductive contact is adapted for operable connection to signal processor, and each conductive contact is electrically insulated from the anterior surface of the eye.

Abstract: A system and method for obtaining information about the spatial distribution of photoreceptor activity and neural activity in the retina using simultaneously recorded multiple biopotential signals. The information thus gathered is used to assess retinal dysfunction due to trauma or disease. The biopotential signals are recorded from the surface of the eye and head using a plurality of electrodes, including those integral to a contact lens. The biopotential signals are recorded before, during and after the presentation of an optical stimulus to the subject eye. The recorded biopotential signals are then analyzed and interpreted to reveal the distribution of photoreceptor activity and neural activity across the retina. The analysis and interpretation of the biopotential signals is quantitative, and makes use of an electromagnetic model of the subject eye. The subject may be animal or human.