Abstract: The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.

Abstract: The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.