Abstract: An endoscopic stent for implantation in a patient after sleeve gastrectomy or biliopancreatic diversion with duodenal switch or biliopancreatic diversion with duodenal switch comprising a stent portion, the stent portion comprising a proximal end portion, the proximal end portion defined by a length of about 50 mm to about 200 mm, an enlarged middle portion, a middle portion having an enlarged diameter relative to the proximal end portion and the distal end portion and defined by a length of about 20 mm to about 80 mm, and a distal end portion and a polymeric sleeve portion engaged to and extending distally from the distal end portion of the stent.

Abstract: This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device includes a stent having a first strut. The first strut may include an inner surface and an outer surface. The medical device may also include a first attachment member coupled to the strut and a radioactive element. The radioactive element may be coupled to the attachment member.

Abstract: A reduced absorption device may include a proximal anchor and a distal sleeve including a frame and a membrane. The membrane may include a plurality of porous regions, and each porous region may be configured to align with a corresponding region of an intestine configured to absorb nutrients.

Abstract: Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include an endoscope and a backstop delivery device extendable through the endoscope. The backstop delivery device may deliver a backstop to a location of selected tissue for resection. A backstop may include a covering being deployable in a patient. The covering may have one or more anchoring mechanisms disposed on an edge of the covering. A tissue resecting device may be extendable through the endoscope for resecting the selected tissue for resection. The covering may be deployable to an outer surface of the body lumen, such that the anchoring mechanism may secure the covering to the outer surface of the body lumen and the covering may expand to cover the selected tissue for resection.

Abstract: The present disclosure relates generally to devices and methods for full thickness tissue resection of an organ (e.g., intestine). In some embodiments, a device includes a conduit, and a plurality of arms rotatably coupled to the conduit. Each of the plurality of arms is movable between a collapsed position and an expanded position, wherein the plurality of arms extends radially outward from the conduit in the expanded position. The device may further include an electrocautery wire coupled to each of the plurality of arms, the electrocautery wire positioned directly adjacent an exterior tissue wall when the plurality of arms is in the expanded position. The device may be advanced back in towards a lumen of the organ until a targeted section of tissue is cut by the electrocautery wire and removed.

Abstract: An implantable medical device for implantation within a passageway of a patient comprises a stent including a plurality of wires, at least one of the plurality of wires having a cross-section having a first tapered point, and a covering layer having an inner diameter and an outer diameter. In some embodiments, the plurality of wires may be disposed at least partially around the covering layer. Additionally in some embodiments, the first tapered point may extend outward further than the outer diameter of the covering layer.

Abstract: A tubular prosthesis that includes a scaffolding formed by at least one scaffolding filament; a cover; and at least one controlled ingrowth feature constructed and arranged to abut an inner surface of a lumen wall when the prosthesis is implanted in the body lumen. The controlled ingrowth feature may extend inwards or outwards from the prosthesis outer surface. The controlled ingrowth feature may be formed by a scaffolding filament; by a separate filament; by the cover; and combinations thereof.

Abstract: An implantable medical device for implantation within a passageway of a patient comprises a stent including a plurality of wires, at least one of the plurality of wires having a cross-section having a first tapered point, and a covering layer having an inner diameter and an outer diameter. In some embodiments, the plurality of wires may be disposed at least partially around the covering layer. Additionally in some embodiments, the first tapered point may extend outward further than the outer diameter of the covering layer.

Abstract: An implantable medical device may comprise an elongated tubular body having a scaffolding forming a plurality of cells. A polymeric covering may be disposed over at least a portion of the stent. The covering may include a plurality of voids formed in an outer surface thereof. An extracellular matrix material coating may be disposed over the polymeric covering and within the plurality of voids.

Abstract: A tubular prosthesis that includes a scaffolding formed by at least one scaffolding filament; a cover; and at least one controlled ingrowth feature constructed and arranged to abut an inner surface of a lumen wall when the prosthesis is implanted in the body lumen. The controlled ingrowth feature may extend inwards or outwards from the prosthesis outer surface. The controlled ingrowth feature may be formed by a scaffolding filament; by a separate filament; by the cover; and combinations thereof.

Abstract: A stent may be actuatable between a delivery configuration and a deployed configuration. A stent may include one or more interwoven filaments each including a cross-sectional profile having at least one flattened portion. A flattened portion of a first filament portion of the one or more filaments may be positioned in contact with a flattened portion of a second filament portion of the one or more filaments.

Abstract: An endoscopic stent for implantation in a patient after sleeve gastrectomy or biliopancreatic diversion with duodenal switch or biliopancreatic diversion with duodenal switch comprising a stent portion, the stent portion comprising a proximal end portion, the proximal end portion defined by a length of about 50 mm to about 200 mm, an enlarged middle portion, a middle portion having an enlarged diameter relative to the proximal end portion and the distal end portion and defined by a length of about 20 mm to about 80 mm, and a distal end portion and a polymeric sleeve portion engaged to and extending distally from the distal end portion of the stent.

Abstract: A stent, the stent including a first coating composition disposed on at least a portion of the outer surface of the stent, the first coating composition having at least one bioadhesive and a second coating composition disposed over the first coating composition, the second coating composition having at least one biodegradable polymer, and methods of making and using the same.

Abstract: The present disclosure relates to the field of endoscopy. Specifically, the present disclosure relates to systems and methods for delivering a therapeutic agent within a body lumen, and maintaining the therapeutic agent in contact with a wall of the body lumen for a beneficial period of time. In particular, the present disclosure relates to systems and methods to prevent lesions within the gastrointestinal tract from spreading into healthy surrounding tissue.

Abstract: An endoscopic stent for implantation in a patient after sleeve gastrectomy or biliopancreatic diversion with duodenal switch or biliopancreatic diversion with duodenal switch comprising a stent portion, the stent portion comprising a proximal end portion, the proximal end portion defined by a length of about 50 mm to about 200 mm, an enlarged middle portion, a middle portion having an enlarged diameter relative to the proximal end portion and the distal end portion and defined by a length of about 20 mm to about 80 mm, and a distal end portion and a polymeric sleeve portion engaged to and extending distally from the distal end portion of the stent.

Abstract: A stent, the stent including a first coating composition disposed on at least a portion of the outer surface of the stent, the first coating composition having at least one bioadhesive and a second coating composition disposed over the first coating composition, the second coating composition having at least one biodegradable polymer, and methods of making and using the same.

Abstract: A device for implanting in a gastrointestinal system of a patient may include an elongate flow modulator configured to be inserted in an intestine, wherein the flow modulator defines an enclosed interior space to hold a fill material.

Abstract: A tissue closure device includes a first clip including a first longitudinal element extending along a longitudinal axis from a proximal end to a distal end and a first pair of arms extending laterally from the first longitudinal element, the first pair of arms movable between an open configuration in which free ends of the first pair of arms are separated from one another and a closed configuration in which the free ends of the first pair of arms extend toward one another, the first pair of arms being biased toward the closed configuration, and a sliding element extending from a proximal end to a distal end and longitudinally movable relative to the first clip so that when a portion of the sliding element is received between the first pair of arms, the first pair of arms is moved from the biased closed configuration to the open configuration.

Abstract: This disclosure provides design, material, preparation methods, and use alternatives for medical devices. An example method of preparing a stent comprises applying a coating to a portion of the stent at a medical treatment facility, the coating including a plurality of radioactive elements and a substrate. The plurality of radioactive elements are mixed with the substrate to form a mixture such that the plurality of radioactive elements are dispersed within the substrate prior to the coating being applied on the stent.

Abstract: A prosthesis that when implanted in the gastrointestinal tract does not impede the normal function of the pyloric sphincter. In some instances, the prosthesis is implanted as part of, or after, a sleeve gastrectomy procedure. The prosthesis includes a stent with an outer surface and a polymeric cover fully covering the outer surface of the stent. The stent includes a proximal stent flange; a proximal stent segment extending distally from the proximal stent flange; and an enlarged stent segment extending distally from the proximal stent segment.