Abstract: The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.

Abstract: The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.

Abstract: The present invention relates to the use of nucleoside derivatives of formula I 1

Abstract: The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known 2′-deoxy-2′-fluoro nucleoside derivatives as inhibitors of hepatitis C virus (HCV) RNA replication and pharmaceutical compositions of such compounds. The compounds of this invention have potential use as therapeutic agents for the treatment of HCV infections.

Abstract: The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known 2′-deoxy-2′-fluoro nucleoside derivatives as inhibitors of hepatitis C virus (HCV) RNA replication and pharmaceutical compositions of such compounds. The compounds of this invention have potential use as therapeutic agents for the treatment of HCV infections.

Abstract: A method of manufacturing a leaf seal for use between rotating components comprises forming corrugations within a metallic strip and feeding the corrugated strip into a seal guide. The corrugated strip is then pressed into the guide by an angled ram such that the corrugations lie at an acute angle to the perpendicular axis. The strip is then secured in a seal carrier, the free ends of the corrugations thus forming the angled sealing leaves of a leaf seal.

Abstract: A process is provided for the manufacture of liquid polysulfide polymers. In particular, the process allows for making the liquid form of the polysulfide polymer directly and eliminates the need to first make a solid polysulfide polymer and then convert it to a liquid.

Abstract: The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.

Abstract: In a vacuum pump of the regenerative type or including a regenerative section in which a rotatable vertical shaft is supported by upper and lower bearings, a lubricating system for lubricating the upper bearing comprising an axial bore extending along the shaft and communicating at its upper end with at least one oil hole in alignment with the upper bearing, the lower open end of the axial bore extending in to a shaft reservoir located in a sump for containing lubricating fluid, the arrangement being such that centrifugal force generated by the rotation of the shaft will cause the lubricating fluid in the shaft reservoir to pass along the axial bore as a thin film towards the oil hole and hence to the upper bearing, in which at least one port is formed in a wall of the shaft reservoir to permit the passage of lubricating fluid therethrough from the sump in a controlled manner dependent upon the head of lubricating fluid in the sump above the port.

Abstract: A method of manufacturing a leaf seal for use between rotating components comprises forming corrugations within a metallic strip and feeding the corrugated strip into a seal guide. The corrugated strip is then pressed into the guide by an angled ram such that the corrugations lie at an acute angle to the perpendicular axis. The strip is then secured in a seal carrier, the free ends of the corrugations thus forming the angled sealing leaves of a leaf seal.

Abstract: Methods to prepare intermediates for the conjugation of active ingredients to hydrophilic carriers are described. The polyhydroxylated carriers are first derivatized to convert the hydroxyls to leaving groups and then reacted with an alkylene diamine in the presence of a reducing agent. The resulting derivatized carrier can then be coupled to substituents containing carboxyl groups in the presence of dehydrating agents.

Abstract: An improved apparatus is used to feed sheet material to a feed station of a collating conveyor. At the feed station of one embodiment of the invention, a first feed drum engages a leading edge portion of the sheet material and feeds the sheet material toward the collating conveyor. A first feed drum feeds the sheets along an arcuate path to a secondary drum. The secondary feed drum feeds the sheet material from another holder to a secondary conveyor. The secondary conveyor is inclined to a horizontal at an angle lesser than the arcuate path. A printer assembly prints indicia on the sheet material. The printer assembly directs ink toward opposite sides of the sheet material along paths which are skewed at an acute angle relative to the vertical so that particles of ink do not fall back onto ink jet nozzles and clog the nozzles.

Abstract: A multi-axle load vehicle has a tractor, a device supporting a load on the tractor and including an axially displaceable holder arranged on the tractor, a supporting plate arranged to support a load, and at least one pin supporting the supporting plate on the holder, and a device for determining a load acting upon the vehicle and including a sensor arranged in the pin composed of a magnetic material and operative for measuring a load and generating an electric signal corresponding thereto, and an indicating element arranged in a driver's cabin and operative for receiving the electrical signal and indicating the load.

Abstract: 2'-Substituted-D-ribofuranosyl purine compounds, especially 2'-azido-D-riuranosyl purine compounds, of the formula ##STR1## in which R.sub.1 is azide, amino, halogen or alkoxy, andR.sub.2 is the residue of a purine base and particularly a 9-adenyl group, a 7-guanyl group, or a 9-guanyl group (the waved lines in formula I above show that R.sub.2 can be bound in the .alpha.- or .beta.-configuration),Are prepared by a process comprising(a) reacting a uridine derivative with an alkali azide (when R.sub.1 is to be azide or, through further conversion, an amine group) or a halide (when R.sub.1 is halogen) or with an alkylating agent (when R.sub.