Abstract: An interatrial shunting device including a tube and an anchoring assembly. The tube defines a first end opposite a second end, and a tube wall extending to and between the first and second ends. The tube wall is a solid body and defines a lumen of the tube, with the lumen being open at the first and second ends. The anchoring assembly is carried by the tube and is configured to secure the interatrial shunting device to a native atrial septum. The solid wall tube prevents tissue overgrowth across the atrial septum, and can have minimal exposure of the device in the left atrium to minimize stroke and other risks. In some examples, the anchoring assembly is configured to be self-transitionable from a delivery state to a deployed state.

Abstract: In accordance with some implementations, various embodiments of a guidewire or catheter having an elongate core with a helical section are provided. In accordance with one implementation, a guidewire is provided. The guidewire includes a core wire having a proximal end, a distal end and is defined by an outer surface between the proximal end and the distal end of the core wire. The core wire has a centerline that traverses the length of the core wire from the proximal end to the distal end of the core wire. The centerline is located approximately at the center of mass along the core wire within the outer surface of the core wire. Preferably, the core wire has a substantially straight proximal portion and a helically curved segment located distally with respect to the proximal portion. The centerline of the core wire is substantially straight along the straight proximal portion, and, the centerline is helically curved along the helically curved segment.

Abstract: A system for treating mitral valve regurgitation comprises a tensioning device slidably received within a delivery catheter. The tensioning device includes a tether linking proximal an anchoring member and a distal anchoring member. At least one of the anchoring members includes an elastic portion that flexes in response to a heartbeat when the tensioning device is positioned across a chamber of a heart. The tether includes at least one locking member initially positioned between the anchoring members. A method for treating mitral valve regurgitation comprises piercing a first wall of a chamber of a heart, engaging a distal anchoring member with a second wall of the heart chamber, engaging a proximal anchoring member with the first wall, and pulling a locking member affixed to a tether linking the anchoring members from an initial position between the two anchoring members to a locked position proximal the proximal anchoring member.

Abstract: A tubular medical catheter having at least one region of selectively varied lamination is provided herein.

Abstract: A tubular medical catheter having a least one region of selectively varied lamination is provided herein.

Abstract: Portions of a cache are flushed in stages. An exemplary flushing of the present invention comprises flushing a first portion, performing operations other than a flush, and then flushing a second portion of the cache. The first portion may be disabled after it is flushed. The cache may be functionally divided into portions prior to a flush, or the portions may be determined in part by an abort signal. The operations may access either the cache or the memory. The operations may involve direct memory access or interrupt servicing.

Abstract: The device utilizes a reversible body partially covered by a blood impermeable sleeve. The device has a low profile collapsed state for delivery and a expanded state for deployment. The impermeable sleeve extends from a proximal portion to a distal portion of the expandable body and generally follows the contour of the expandable body. When deployed, the device is configured in the expanded state and has a generally hourglass, or dumbbell shape. In the expanded state, portions of the sleeve adjacent to the proximal and distal portions are placed in apposition to a vessel wall and blood is free to flow through the expandable body via inlets and outlets provided in the proximal and distal portions. As a result, an isolated treatment space is created that surrounds the device between the vessel wall and the blood impermeable sleeve adjacent to the neck portion of the expandable body.

Abstract: A system for treating mitral valve regurgitation comprises a tensioning device slidably received within a delivery catheter. The tensioning device includes a tether linking proximal an anchoring member and a distal anchoring member. At least one of the anchoring members includes an elastic portion that flexes in response to a heartbeat when the tensioning device is positioned across a chamber of a heart. The tether includes at least one locking member initially positioned between the anchoring members. A method for treating mitral valve regurgitation comprises piercing a first wall of a chamber of a heart, engaging a distal anchoring member with a second wall of the heart chamber, engaging a proximal anchoring member with the first wall, and pulling a locking member affixed to a tether linking the anchoring members from an initial position between the two anchoring members to a locked position proximal the proximal anchoring member.

Abstract: A tubular medical catheter having a least one region of selectively varied lamination is provided herein.

Abstract: A tubular medical catheter having an inner liner comprising ultra high molecular weigh high density polyethylene, and methods of making the same, are provided herein.