Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

Abstract: Systems, methods, and computer program products are provided herein for data security model modification and anomaly detection. An example method includes receiving a model input associated with one or more data entries of a data security model and accessing the data security model. The data security model includes a plurality of data objects including one or more data entries where each data object defines an associated model level indicative of the hierarchical position of the data object within the data security model and one or more links between the data objects that define data object interdependency parameters. The example method further includes determining one or more data objects of the data security model implicated by the model input and modifying one or more data entries of the one or more implicated data objects of the data security model in response to the model input.

Abstract: A compact muffler (40) for an engine exhaust system, which is particularly applicable for use with small, reciprocating piston two-stroke engines of the type used on unmanned aerial vehicles (UAVs). The compact muffler (40) comprises an exhaust gas flow path (67) between an inlet (61) and an outlet (63). The exhaust gas flow path (67) comprises a plurality of adjacent flow passages (65), wherein at least two of the adjacent flow passages (65) are fluidly connected in series to enable the flow of exhaust gas from one to the other along the flow path (67). The adjacent flow passages (65) are configured for fluid flow therealong in opposed directions. A bypass passage (70) is provided between the two adjacent flow passages (65) for further communication between the two flow passages and to promote an equalisation of fluid pressure within the two adjacent passages (65). A UAV having an internal combustion engine (31) fitted with an exhaust system comprising the compact muffler (40) is also disclosed.

Abstract: Vaccines and methods of expressing a polypeptide of Eimeria are provided in which a protective response to Eimeria is produced when administered to an animal. The vaccine provides for expression of Eimeria vaccine proteins 3-1e, Gam82, and/or EF-1a polypeptide in a plant or plant part, linked to a promoter preferentially directing expression to embryo tissue of the plant or plant part. Further embodiments provide that the polypeptide may be targeted to the apoplast/cell wall or the endoplasmic reticulum. Increased expression levels in the plant or plant part are obtained. The plant or plant materials in an embodiment may be orally administered.

Abstract: In variants, the system can include a set of vehicles, cooperatively capable of forming a platoon. Each vehicle within the platoon can be configured to operate based on feedback from other vehicles within the platoon. In examples, a vehicle can selectively brake based on feedback from other vehicles within the platoon.

Abstract: A method includes obtaining an electrocardiogram (ECG) signal during a scan of a heart of a subject with a CT scanner. The method includes calculating temporal R-R electrocardiogram interval measurements from the ECG signal. The method includes monitoring whether any irregular cardiac cycles are detected in the temporal R-R electrocardiogram interval measurements. The method includes determining whether an initial Z coverage of the scan is sufficient for obtaining an artifact free image of the heart at a target phase when one or more irregular cardiac cycles are detected. The method includes determining a required Z coverage to obtain the artifact free image of the heart at the target phase when the initial Z coverage is not sufficient. The method includes initiating a rescan of the heart to obtain the required Z coverage while continuing both to obtain the ECG signal and to monitor for any irregular cardiac cycles.

Abstract: A diverse sensor integration system includes a system controller, at least one system sensor, and a plurality of selectable sensor modules. Each selectable sensor module is operably connected between the system controller and the system sensor. The selectable sensor modules receive an input signal with a set of first characteristics from the system sensor and convert it into an output signal with a set of second signal characteristics required by the system controller. The output signal is then transmitted to the system controller. This integration system allows for the seamless integration of different types of sensors into a single system, providing flexibility and adaptability to meet various system requirements.

Abstract: Vaccines and methods of expressing a polypeptide of Borrelia burgdorferi are provided in which a protective response to Borrelia burgdorferi is produced when administered to an animal. The vaccine provides for expression of the Borrelia burgdorferi OspA polypeptide in a plant or plant part, linked to a promoter preferentially directing expression to embryo tissue of the plant or plant part. Further embodiments provide that the polypeptide may be targeted to the apoplast/cell wall or the endoplasmic reticulum. Increased expression levels in the plant or plant part are obtained. The plant or plant materials in an embodiment may be orally administered.

Abstract: The present disclosure generally relates to methods and system used to collect and reuse polishing fluids used during a chemical mechanical polishing (CMP) process for the fabrication of electronic devices. More specifically, systems and methods provided herein include a polishing fluid collection system having a catch basin, a vacuum device, and a polishing fluid recycling module for recycling polishing fluid.

Abstract: A sensor element for a cutting tool (100) has a hard portion (110) having a sensing surface (112), first and second electrodes (120, 130), first and second sets of thermocouple wires (122, 132) and an electrically insulating portion. The first and second electrodes (120, 130) are arranged to allow electric current to flow when the sensing surface (112) contacts external material in response to the cutting tool engaging the external material. A first thermocouple junction (124) is operable to indicate a temperature of the first electrode and a second thermocouple junction (134) is operable to measure temperature of the second electrode.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to route display stream data. An example system disclosed herein to route display stream data includes a circuit board comprising decoding circuitry to decode Peripheral Component Interconnect Express (PCIe) data packets into a display port stream data, the PCIe data packets encoded by a discrete graphics circuitry, and a Universal Serial Bus (USB) connector on the circuit board coupled to the decoding circuitry, wherein the USB connector is to output the display port stream data.

Abstract: A linac-based X-ray system for cargo scanning and imaging applications uses linac design, RF power control, beam current control, and beam current pulse duration control to provide stable sequences of pulses having different energy levels or different dose.

Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.

Abstract: Vaccines and methods of expressing a polypeptide of Eimeria are provided in which a protective response to Eimeria is produced when administered to an animal. The vaccine provides for expression of Eimeria vaccine proteins 3-1e, Gam82, and/or EF-1a polypeptide in a plant or plant part, linked to a promoter preferentially directing expression to embryo tissue of the plant or plant part. Further embodiments provide that the polypeptide may be targeted to the apoplast/cell wall or the endoplasmic reticulum. Increased expression levels in the plant or plant part are obtained. The plant or plant materials in an embodiment may be orally administered.

Abstract: A system includes a measurement device having an electronic distance measurement (EDM) instrument, and at least one processor coupled to the EDM instrument. The at least one processor is configured to localize the measurement device relative to a design model, the measurement device being physically located at a measurement location, automatically generate, for at least one design element in the design model, a plurality of sample directions, control the EDM instrument to automatically perform measurements in the plurality of sample directions, and generate and output a verification result indicating a relation between the at least one design element and at least one object corresponding to the at least one design element, based on a shape of the at least one design element and measurement data of the measurements.

Abstract: The present disclosure provides methods of converting cellulose in grain to glucose for ethanol production. By providing cost-effective cellulases expressed in the grain, the methods increase glucose yield compared to the use of starch degrading amylase enzymes alone.

Abstract: A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid collector for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid collector. The vacuum connection may be separated from the liquid collector by a liquid barrier.

Abstract: A linac-based X-ray system for cargo scanning and imaging applications uses linac design, RF power control, beam current control, and beam current pulse duration control to provide variable controlled dose per pulse to permit scanning a portion of a vehicle at a dose safe for humans and scanning a cargo portion of a vehicle at substantially increased dose per pulse.

Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.

Abstract: A system is provided for electronic data obfuscation and protection using independent destructible data objects. The system may split a set of data into a data portion and a key portion, where the data portion may be stored in a database separately from the key portion. The data portion may further comprise a set of executable code for a time or iteration based destructible data object, where the data object may incrementally decrease a countdown value based on the passage of time and/or iterations. If the countdown value reaches a threshold value without being refreshed, the data object may automatically execute one or more processes to protect the set of data. In this way, the system provides a secure way to prevent unauthorized access to sensitive data.