Abstract: The present disclosure relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.

Abstract: A mount assembly for securing a solar panel rail or rail-less support structure directly to a roof surface, the mount assembly including: a base having a top surface and a bottom surface; a guide extending upwards from the top surface of the base, where the guide forms a pair of members extending from opposing sides of the base and an aperture between the pair of members; a cavity formed within the base, where the cavity has an open end and a bottom cavity surface, where the open end is open relative to the top surface of the base; a through-hole, where the through-hole passes from the bottom cavity surface to the bottom surface of the base; a fastener, where the fastener is sized to pass through the through-hole; and a piston member, where the piston member is configured to surround a portion of the fastener, and further where the piston member is sized to have a volume that is equal to or greater than a volume of the cavity formed within the base.

Abstract: A wire clamp may include a bottom piece having: a first base portion defining a first aperture, an at least partially elliptical barrier extending from the first base portion about the first aperture, and a plurality of legs extending from sides of the first base portion; a top piece having: a second base portion, a protrusion extending from the second base portion, the protrusion defining a second aperture, and a plurality of legs extending from sides of the second base portion; and a fastener. The first aperture and the second aperture may be configured to align and receive the fastener therethrough. A first side of the partially elliptical barrier and a first portion of the plurality of legs may define a first wire channel, and a second side of the partially elliptical barrier and a second portion of the plurality of legs may define a second wire channel.

Abstract: A wire clamp may include a bottom piece having: a first base portion defining a first aperture, an at least partially elliptical barrier extending from the first base portion about the first aperture, and a plurality of legs extending from sides of the first base portion; a top piece having: a second base portion, a protrusion extending from the second base portion, the protrusion defining a second aperture, and a plurality of legs extending from sides of the second base portion; and a fastener. The first aperture and the second aperture may be configured to align and receive the fastener therethrough. A first side of the partially elliptical barrier and a first portion of the plurality of legs may define a first wire channel, and a second side of the partially elliptical barrier and a second portion of the plurality of legs may define a second wire channel.

Abstract: Kidney stone removal system is disclosed having components including a handle mechanism. The handle mechanism employs a trigger mechanism that enables control of irrigation and vacuum/suction. Operation of a trigger of the trigger mechanism conveys status of vacuum/suction and irrigation to a user by providing increased resistance at different points of operation. When the trigger is in a home position, irrigation and vacuum/suction are turned off. When the trigger is in a fully activated position, irrigation and vacuum/suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum/suction remains turned off. The handle mechanism can be of a single trigger design with modes including: an active irrigation mode only (i.e., active irrigation on/vacuum off) and an active irrigation mode in combination with a vacuum mode (i.e., active irrigation on/vacuum on).

Abstract: A method for quantifying bacterial spore germination can include creating an ex vivo assay including bacteria spores and a homogenized stool sample. The ex vivo assay can be loaded into a microfluidic chip. Vegetative bacteria and the bacteria spores can be detected by sampling the mixture in the microfluidic chip using impedance cytometry to assess disruption of host microbiota.

Abstract: Devices, systems and methods for distribution of digital content are set forth, wherein a distributed media player is provided comprising a a central playout server having a multiplexed media processing block within a tamper-responsive enclosure, the central playout server having a first input for receiving at least one decryption key and a second input for receiving media data from a content provider in response to which the multiplexed media processing block decrypts the media data using the at least one decryption key and transmits the decrypted media data over a local network to a plurality of devices as an encrypted data stream.

Abstract: The present invention relates generally to a population of stem cells (e.g., iPSCs or HSCs) that comprise nucleic acids encoding a T cell receptor and a chimeric antigen receptor directed to multiple distinct antigenic determinants, for example two distinct tumour antigenic determinants. The present invention is also directed to a population of T cells that co-express a T cell receptor and a chimeric antigen receptor directed to multiple distinct antigenic determinants, such as two distinct tumour antigenic determinants. The cells of the present invention can be derived from chosen donors whose HLA type is compatible with significant sectors of the populations, and are useful in a wide variety of applications, in particular in the context of the therapeutic treatment of neoplastic conditions.

Abstract: Devices, systems and methods for distribution of digital content are set forth, wherein a distributed media player is provided comprising a a central playout server having a multiplexed media processing block within a tamper-responsive enclosure, the central playout server having a first input for receiving at least one decryption key and a second input for receiving media data from a content provider in response to which the multiplexed media processing block decrypts the media data using the at least one decryption key and transmits the decrypted media data over a local network to a plurality of devices as an encrypted data stream.

Abstract: When a user of an interface system defines a workflow, the interface system transmits a notification to a user that is to perform the first step of the workflow. When the user requests to initiate the step of the workflow, the interface system creates a transaction for the workflow step. The user signs the transaction using a cryptographic key pair. The interface system receives the signed transaction and verifies the signature. Once the signature is verified, the step can be performed. The interface system forwards the transaction to a data storage system for storing. For performing the next step in the workflow, the data storage system identifies the user that is to perform the next workflow step. The data storage system creates a notification that identifies the user and the notification is provided to the user. The process repeats until each step of the workflow is performed.

Abstract: This disclosure provides a dissolvable sealing joint system that can be used in an improved method of sealing a multi-lateral well junction. The sealing joint system is comprised of a dissolvable junction subassembly that can be easily removed after a sealing operation is conducted. A tapered end of the dissolvable junction subassembly is inserted in a liner of a secondary wellbore, and a seal located about the tapered end is sealed against the top of the liner and a no-go shoulder of dissolvable junction subassembly. Once a seal is established, an isolation fluid is pumped into the junction area via a fluid port located in the dissolvable junction subassembly. A method of isolating a wellbore junction is also presented.

Abstract: An LED fixture is provided for photographic and theatrical lighting. The light fixture is particularly suitable for photographic and theatrical lighting by mounting LED elements directly or indirectly on articulating arms. The arms have a first pivot mounted segment connected by a hinge to a hub and a second pivot mounted segment connected by an intermediate hinge to said first pivot mounted segment.

Abstract: A porcelain enamel composition may include a glass component including: at least one alkali oxide in an amount ranging from about 6 to 21 wt %, SiO2 in an amount ranging from about 20 to 50 wt %, ZnO in an amount ranging from about 0.1 to 10 wt %, Al2O3 in an amount ranging from about 5 to 20 wt %, B2O3 in an amount ranging from about 0.1 to 20 wt %, and P2O5 in an amount ranging from about 5 to 30 wt %, all weight percentages expressed relative to the enamel composition. Methods of using such compositions and formed products are also described.

Abstract: A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.

Abstract: This disclosure provides a dissolvable sealing joint system that can be used in an improved method of sealing a multi-lateral well junction. The sealing joint system is comprised of a dissolvable junction subassembly that can be easily removed after a sealing operation is conducted. A tapered end of the dissolvable junction subassembly is inserted in a liner of a secondary wellbore, and a seal located about the tapered end is sealed against the top of the liner and a no-go shoulder of dissolvable junction subassembly. Once a seal is established, an isolation fluid is pumped into the junction area via a fluid port located in the dissolvable junction subassembly. A method of isolating a wellbore junction is also presented.

Abstract: A data integrity system generates a transaction signature associated with a transaction based on transaction data received from a data producer. The transaction signature is unique to the transaction and is generated by applying a hash function to the transaction data. When the transaction data is to be transmitted to a data consumer, the data integrity system redacts the transaction data based on permission information associated with the data consumer and transmits the redacted transaction data to the data consumer. To enable the data consumer to verify the integrity of the received data, the data integrity system also transmits a cryptographic assurance that includes at least the transaction signature associated with the transaction. The data consumer verifies the integrity of the received data by independently generating a transaction signature based on the redacted transaction data and matching the independently generated signature with the transaction signature in the cryptographic assurance.

Abstract: A data storage system creates a data signature for a data element that is to be stored by hashing the data element. The data storage system also creates a sequence signature for the data element and stores the sequence signature in a signature database. The sequence signature is created using the data signature of the data element and the previous sequence signature stored in the signature database. The data storage system transmits a copy of the sequence signature to an anchor system. The anchor system stores the copy as an export anchor and creates an import anchor based on the export anchor and information associated with the present time. The anchor system stores the import anchor and transmits a copy to the data storage system. An audit system uses the export anchor and import anchor to determine whether data stored by the data storage system has been modified.

Abstract: A coupling assembly for coupling solar photovoltaic modules together in an array includes a base portion including a base surface for operatively engaging a bottom surface of at least one of the solar photovoltaic modules. The coupling assembly also includes a cap portion including a clamping surface located opposite the base surface for operatively engaging a top surface of at least one of the solar photovoltaic modules. The coupling assembly further includes a spacer slidably mounted to one of the base portion or the cap portion and having first and second abutment sides each configured to operatively engage a side surface of at least one of the solar photovoltaic modules. The base surface and the clamping surface are moveable relative to each other such that movement of the clamping surface toward the base surface provides a clamping action on at least one of the solar photovoltaic modules positioned therebetween.

Abstract: A porcelain enamel composition may includes a glass component including: at least one alkali oxide in an amount ranging from about 6 to 21 wt %, SiO2 in an amount ranging from about 20 to 50 wt %, ZnO in an amount ranging from about 0.1 to 10 wt %, AI2O3 in an amount ranging from about 5 to 20 wt %, B2O3 in an amount ranging from about 0.1 to 20 wt %, and P2O5 in an amount ranging from about 5 to 30 wt %, all weight percentages expressed relative to the enamel composition. Methods of using such compositions and formed products are also described.

Abstract: According to the invention, an LED fixture is provided for photographic and theatrical lighting. The light fixture is particularly suitable for photographic and theatrical lighting by mounting LED elements directly or indirectly on articulating arms. The arms rotate 90 degrees from a position where the arms are aligned substantially in parallel with an axis of the fixture hub and may be rotated 90 degrees for deployment of the fixture. In addition, the spokes may be flexed beyond the alignment permitted by the cooperation between the hub and mounting elements.