Abstract: N-(3-substituted thiazaheterocyclylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides, N-(3-substituted thiazaheterocyclylidene)-1H-pyrrolo[2,3-b]pyridine-4-carboxamides and N-(3-substituted thiazaheterocyclylidene)-1H-pyrrolo[3,2-b]pyridine-1-carboxamides wherein the ring designated Q or Q? is a five-, six-, or seven-membered heterocycle containing one sulfur and one nitrogen are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.

Abstract: Provided herein are soluble adenylyl cyclase (sAC) inhibitors and uses thereof. In one aspect, provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and pharmaceutical compositions thereof. The compounds provided herein are soluble adenylyl cyclase (sAC) inhibitors and are therefore useful for the treatment and/or prevention of various diseases and conditions (e.g., ocular conditions (e.g., ocular hypotony), liver diseases (e.g., non-alcoholic steatohepatitis (NASH)), inflammatory diseases, autoimmune diseases (e.g., psoriasis)). Compounds provided herein are also useful as contraceptive agents (e.g., for male and female contraception).

Abstract: The present invention relates to a method for preparing a polysiloxane-polycarbonate block co-condensate, wherein a siloxane component containing both aliphatic and aromatic groups is used as a mediator. The invention also relates to a polycarbonate composition and also to the use of the special siloxane component for reducing the particle size distribution of the siloxane domains in a polysiloxane-polycarbonate block co-condensate.

Abstract: N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.

Abstract: The present invention relates to a method for preparing a polysiloxane-polycarbonate block co-condensate, wherein a siloxane component containing both aliphatic and aromatic groups is used as a mediator. The invention also relates to a polycarbonate composition and also to the use of the special siloxane component for reducing the particle size distribution of the siloxane domains in a polysiloxane-polycarbonate block co-condensate.

Abstract: The subject of the present invention is a process for the production of polysiloxane-polycarbonate block cocondensates, wherein A) at least one polycarbonate is reacted in the melt with B) at least one hydroxyaryl-terminated polysiloxane with use C) of an additive which is selected from at least one from the group consisting of a siloxane containing aromatic substituents (component C1) and a polysiloxane-polycarbonate block cocondensate A) or polysiloxane-polycarbonate block cocondensate, which can also be different from A) (component C2).

Abstract: The present invention relates to aqueous compositions comprising one or more silicones and a synergistic combination of anti-microbiological agents, to a process for preparing the aqueous compositions, and to the use of said aqueous compositions, in particular, for the manufacture of home care articles, household cleansing articles, fabric articles, cosmetic articles, hygienic articles, medical articles etc.

Abstract: Insect repellants are disclosed. Methods of making and using insect repellants are also disclosed.

Abstract: The subject of the present invention is a process for the production of polysiloxane-polycarbonate block cocondensates, wherein A) at least one polycarbonate is reacted in the melt with B) at least one hydroxyaryl-terminated polysiloxane with use C) of an additive which is selected from at least one from the group consisting of a siloxane containing aromatic substituents (component C1) and a polysiloxane-polycarbonate block cocondensate A) or polysiloxane-polycarbonate block cocondensate, which can also be different from A) (component C2).

Abstract: The present invention relates to aqueous compositions comprising one or more silicones and a synergistic combination of anti-microbiological agents, to a process for preparing the aqueous compositions, and to the use of said aqueous compositions, in particular, for the manufacture of home care articles, household cleansing articles, fabric articles, cosmetic articles, hygienic articles, medical articles etc.

Abstract: Insect repellants are disclosed. Methods of making and using insect repellants are also disclosed.

Abstract: Disclosed herein are compositions, comprising linear polydiorganosiloxanes having enhanced reactivity and their use to prepare polydiorganosiloxane-polyorgano block copolymers.

Abstract: Disclosed are processes for preparing sol-gel resins from phenolic compounds and aldehydes. The process includes reacting an hydroxylated benzene and a catalyst with an aldehyde to form a liquid storage stable intermediate. The storage stable intermediate may then be stored for a period of time before being utilized in a process to prepare the sol-gel resin, in either monolith or particle form, by subsequently reacting the intermediate with an hydroxylated benzene and a catalyst.

Abstract: Disclosed herein are compositions, comprising linear polydiorganosiloxanes having enhanced reactivity and their use to prepare polydiorganosiloxane-polyorgano block copolymers.

Abstract: Sol-gel resins can be prepared using one or two-step processes to produce small granules or pellets of resin that are easy to handle. The methods include agitating phenolic compounds and aldehydes in the presence of a catalyst and a solvent. The reactants are brought together over a period of time to avoid an undesirable buildup of heat within the reaction mass. Condensation of the material continues under agitation sufficient to knead the material as it gels. During this gelation, the material begins to form into smaller parts until particles, the shape of granules, are produced. The condensation continues to the degree that the material is no longer capable of sintering during packaging and storage. The material thus made can be easily discharged, packaged, portioned, and further processed.

Abstract: Sol-gel resins can be prepared using one or two-step processes to produce small granules or pellets of resin that are easy to handle. The methods include agitating phenolic compounds and aldehydes in the presence of a catalyst and a solvent. The reactants are brought together over a period of time to avoid an undesirable buildup of heat within the reaction mass. Condensation of the material continues under agitation sufficient to knead the material as it gels. During this gelation, the material begins to form into smaller parts until particles, the shape of granules, are produced. The condensation continues to the degree that the material is no longer capable of sintering during packaging and storage. The material thus made can be easily discharged, packaged, portioned, and further processed.

Abstract: Disclosed are processes for preparing sol-gel resins from phenolic compounds and aldehydes. The process includes reacting an hydroxylated benzene and a catalyst with an aldehyde to form a liquid storage stable intermediate. The storage stable intermediate may then be stored for a period of time before being utilized in a process to prepare the sol-gel resin, in either monolith or particle form, by subsequently reacting the intermediate with an hydroxylated benzene and a catalyst.