Patents by Inventor John Hughes

John Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5861295
    Abstract: The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including through use of the polymerase chain reaction (PCR).
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: January 19, 1999
    Assignee: Life Technologies, Inc.
    Inventors: Adam S. Goldstein, A. John Hughes, Jr.
  • Patent number: 5708706
    Abstract: Mobile telephone apparatus comprises a transceiver unit (10) having a handset cradle (12), signal antenna (14) and ports (16-24) for the connection of a handset, external loudspeaker/microphone, power supply etc. A power lead (26) for connecting the power supply port (24) of the apparatus to a cigarette lighter socket is stored when not in use by plugging the cigarette lighter adaptor (36) at one end of the lead (26) into a dummy socket (44) formed in a housing (42) which is detachably connected to the transceiver unit (10). The lead (26) is combined with a carrying strap (28), one end of which is connected to the cigarette lighter adapter and the other end (30) of which is detachably connectable to a retaining slot (32) on the transceiver unit (10).
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: January 13, 1998
    Assignee: Nokia Mobile Phones Limited
    Inventors: Nevil John Hughes, Robert Clifford Newstead, Kevin John Yates
  • Patent number: 5684047
    Abstract: The subject invention pertains to methods of using 4-guanidinobutyramide, or a physiologically-acceptable salt thereof, in a mammal or human to improve blood circulation.
    Type: Grant
    Filed: June 16, 1995
    Date of Patent: November 4, 1997
    Assignee: Cemorc Ltd
    Inventor: William John Hughes Butterfield
  • Patent number: 5577463
    Abstract: An animal litter including an extruded smectite clay that forms stronger clumps, when wetted with animal urine, due to the extrusion process. In a preferred embodiment, the extruded smectite clay is mixed, before or after extrusion, with a small percentage, preferably at least about 0.025% to less than 0.1%, based on the dry weight of the smectite clay, of a water-soluble adhesive that forms improved, stronger, more cohesive clumps that can be essentially completely removed from a litter box leaving the remaining litter box contents odor-free.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: November 26, 1996
    Assignee: AMCOL International Corporation
    Inventors: Carol Elazier-Davis, Gary W. Beall, John Hughes
  • Patent number: 5550126
    Abstract: Pharmaceutical compositions and methods of using CCK-ligands D,L-glutamic acid and D,L-aspartic acid as antipsychotic, antianxiety, and agents useful in treatment or prevention of withdrawal symptoms caused by withdrawal of chronic or long term use of diazepam, alcohol, cocaine or nicotine and antianxiety agents are described.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: August 27, 1996
    Assignee: Merck Sharp and Dohme Limited
    Inventors: David C. Horwell, John Hughes, Geoff N. Woodruff
  • Patent number: 5503111
    Abstract: A composition and method of absorbing animal dross. In one embodiment, the composition comprises discrete particles (about 50 microns to about 3350 microns, preferably about 600 microns to about 3350 microns in size) of a non-compacted water-swellable bentonite clay that effectively absorbs animal dross and simultaneously agglomerates into a sufficiently large and stable mass, thereby permitting physical separation of the soiled and wetted water-swellable bentonite clay particles from discrete particles of the unsoiled and unwetted water-swellable bentonite clay even after partial drying of about 1 to about 24 hours at room temperature, without substantial sticking to animal paws and fur.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: April 2, 1996
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5452684
    Abstract: An animal litter including an extruded smectite clay that forms stronger clumps, when wetted with animal urine, due to the extrusion process. In a preferred embodiment, the extruded smectite clay is mixed, before or after extrusion, with a small percentage, preferably at least about 0.025% to less than 0.1%, based on the dry weight of the smectite clay, of a water-soluble adhesive that forms improved, stronger, more cohesive clumps that can be essentially completely removed from a litter box leaving the remaining litter box contents odor-free.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: September 26, 1995
    Assignee: American Colloid Company
    Inventors: Carol Elazier-Davis, Gary W. Beall, John Hughes
  • Patent number: 5427990
    Abstract: A method of treating a water-swellable clay after the clay has been mined and dried to improve its properties when in contact with salt-contaminated water. After the common initial drying of the clay to a moisture content of 12% by weight or less, the clay is rewetted to a moisture content of more than 12% by weight, preferably at least about 15% or more, based on the dry weight of the clay, then redried to a moisture content of 12% by weight or less, based on the dry weight of the clay.
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: June 27, 1995
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5426079
    Abstract: A method of treating a water-swellable clay, initially having a Fe.sup.+3 /Fe.sup.+2 ratio of at least 1.0, preferably at least 3.0, and most preferably in the range of about 5.0 to about 15.0, after the clay has been mined and dried. After the common initial drying of the clay to a moisture content of 12% or less, the clay is re-wetted to a moisture content of more than 12% by weight, preferably at least about 15% or more, based on the dry weight of the clay, then re-dried to a moisture content of 12% by weight or less, based on the dry weight of the clay.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: June 20, 1995
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5386803
    Abstract: A composition and method of absorbing animal dross. Discrete particles of a composition comprising a combination of bentonite clays, particularly about 1% to about 50% by weight sodium bentonite, and about 50% to abut 99% by weight Fuller's Earth, or calcium bentonite, absorbs animal dross and related liquids, and simultaneously agglomerate into a sufficiently large and stable mass when contacted with the animal dross, and, unexpectedly, the agglomerates readily disperse in water so that the agglomerates can be disposed of in water, such as by being flushed down a toilet, or disposed of through other household plumbing lines without clogging the plumbing lines. The agglomerates can be physically separated and removed from unwetted particles of the composition. Removing the wetted and agglomerated composition particles from the remaining unwetted composition reduces or eliminates offensive odors produced by dross-soaked particles.
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: February 7, 1995
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5356678
    Abstract: A pouch for absorbing liquids. On one embodiment, the ouch is formed from two distinct layers of sheet material--one including thermoplastic fibers for the purpose of heat sealing and the other a tearable tissue paper capable of tearing upon expansion of the water-absorbent material contained between the sheet material layers. In another embodiment, the pouch is manufactured to include a relatively weak sealed seam, e.g., formed by heat sealing adjacent sheet material layers together, that has a weaker bonding strength than one or more other sealed seams, such that upon expansion of the water-absorbent material, the relatively weak seam separates or delaminates into its separate layers to allow the absorbent to spread beyond the pouch at the relative weak seam. In both embodiments, the pouches contain an inner layer of water-insoluble, liquid-absorbing material, such as cross-linked sodium polyacrylate.
    Type: Grant
    Filed: March 17, 1993
    Date of Patent: October 18, 1994
    Assignee: American Colloid Company
    Inventors: Kevin Heitzhaus, Lisa Sherman, John Hughes
  • Patent number: 5333673
    Abstract: Molten metal is cast into a mold cavity formed of sand held in a predetermined mold configuration by a binder comprising a plurality of sodium bentonite clays. A blend of two or more sodium bentonite clays obtained from different areas as a foundry sand binder synergistically and unexpectedly improves the foundry sand used as a mold cavity for casting metal objects by unexpectedly improving one or more of the following foundry sand properties beyond the level of either of the blended sodium bentonites alone: green compressive strength; hot compressive strength; dry compressive strength; wet tensile strength; flowability; surface finish; activation speed and shakeout.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: August 2, 1994
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5318953
    Abstract: A method of treating a water-swellable clay, initially having a Fe.sup.+3 /Fe.sup.+2 ratio of at least 1.0, preferably at least 3.0, and most preferably in the range of about 5.0 to about 15.0, after the clay has been mined and dried. After the common initial drying of the clay to a moisture content of 12% or less, the clay is re-wetted to a moisture content of more than 12% by weight, preferably at least about 15% or more, based on the dry weight of the clay, then re-dried to a moisture content of 12% by weight or less, based on the dry weight of the clay.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: June 7, 1994
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5317990
    Abstract: A composition and method of absorbing animal dross. In one embodiment, the composition comprises discrete particles (about 50 microns to about 3350 microns, preferably about 600 microns to about 3350 microns in size) of a non-compacted water-swellable bentonite clay that effectively absorbs animal dross and simultaneously agglomerates into a sufficiently large and stable mass, thereby permitting physical separation of the soiled and wetted water-swellable bentonite clay particles from discrete particles of the unsoiled and unwetted water-swellable bentonite clay even after partial drying of about 1 to about 24 hours at room temperature, without substantial sticking to animal paws and fur.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: June 7, 1994
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5312807
    Abstract: A method of treating a water-swellable clay after the clay has been mined and dried to improve its properties when in contact with salt-contaminated water. After the common initial drying of the clay to a moisture content of 12% by weight or less, the clay is rewetted to a moisture content of more than 12% by weight, preferably at least about 15% or more, based on the dry weight of the clay, then redried to a moisture content of 12% by weight or less, based on the dry weight of the clay.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: May 17, 1994
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5275114
    Abstract: A foundry sand binder composition and method of manufacturing cast metal objects by casting molten metal into a mold cavity formed of sand held in a predetermined mold configuration by a binder comprising a plurality of sodium bentonite clays. A blend of two or more sodium bentonite clays obtained from different areas as a foundry sand binder synergistically and unexpectedly improves the foundry sand used as a mold cavity for casting metal objects by unexpectedly improving one or more of the following foundry sand properties beyond the level of either of the blended sodium bentonites alone: green compressive strength; hot compressive strength; dry compressive strength; wet tensile strength; flowability; surface finish; activation speed and shakeout.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: January 4, 1994
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5209768
    Abstract: A method of improving the yield of a germinating sod crop and a method of promoting the root formation and the vegetative growth of transplanted sod utilizing an aqueous gel including a highly-absorbent, crosslinked, mixed salt of homopolymerized or copolymerized acrylic acid. The aqueous gel utilized in the method of the present invention demonstrates an improved sod crop yield and improved sod growth even in the absence of plant nutrients.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: May 11, 1993
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5173344
    Abstract: An article of manufacture including an elongate confined mass of a water-swellable clay for sealing joints or seams between adjacent water-barrier materials or for plugging defects or other unsealed areas adjacent to a water-barrier layer. The elongate, confined mass of water-swellable clay is manufactured in any desired cross-sectional shape or configuration e.g. circular, eliptical, rectangular, square, and the like and can be manufactured in roll form for dispensing individual confined masses of water-swellable clay individually. The water-swellable clay is confined within a layer of material that permits the entrance of water to contact the water-swellable clay for hydration of the clay, such as by being water-porous or water-soluble and such that upon sufficient hydration of the confined mass of water-swellable clay, the confining layer will dissolve sufficiently, burst or tear to permit relatively free movement of the hydrating and expanding water-swellable clay.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: December 22, 1992
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: 5129365
    Abstract: A composition and method of absorbing animal dross. In one embodiment, the composition comprises discrete particles (about 50 microns to about 3350 microns, preferably about 600 microns to about 3350 microns in size) of a non-compacted water-swellable bentonite clay that effectively absorbs animal dross and simultaneously agglomerates into a sufficiently large and stable mass, thereby permitting physical separation of the soiled and wetted water-swellable bentonite clay particles from discrete particles of the unsoiled and unwetted water-swellable bentonite clay even after partial drying of about 1 to about 24 hours at room temperature, without substantial sticking to animal paws and fur.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: July 14, 1992
    Assignee: American Colloid Company
    Inventor: John Hughes
  • Patent number: H1531
    Abstract: The invention relates to a substantially pure thermostable DNA polymerase. Preferably, the DNA polymerase has a molecular weight of about 95 kilodaltons and is more thermostable than Taq DNA polymerase. The present invention also relates to cloning and expression of the DNA polymerase in E. coli, to DNA molecules containing the cloned gene, and to host cells which express said genes.
    Type: Grant
    Filed: April 18, 1994
    Date of Patent: May 7, 1996
    Inventors: Ilse I. Blumentals, Roger S. Lasken, Brian J. Schmidt, Mary C. Longo, A. John Hughes, Jr., Deb K. Chatterjee