Patents by Inventor John Hynes, Jr.

John Hynes, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
    Patent number: 7211666
    Abstract: Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: May 1, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jollie Duaine Godfrey, Jr., John Hynes, Jr., Alaric J. Dyckman, Katerina Leftheris, Zhongping Shi, Stephen T. Wrobleski, Wendel William Doubleday, John A. Grosso
  • Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
    Patent number: 6867300
    Abstract: Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: March 15, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jollie Duaine Godfrey, Jr., John Hynes, Jr., Alaric J. Dyckman, Katerina Leftheris, Zhongping Shi, Stephen T. Wrobleski, Wendel William Doubleday, John A. Grosso
  • Non-peptide peptidomimetics
    Patent number: 6197963
    Abstract: Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: wherein at least one of R1, R2, R3, R4, or R5 comprises a functional group which is chemically similar to that found in the peptide of interest.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: March 6, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, John Hynes, Jr., Maria A. Cichy-Knight, Rachel D. van Rijn, Paul A. Sprengeler, P. Grant Spoors, William C. Shakespeare, Sherrie Pietranico-Cole, Amos B. Smith, III