Abstract: A mail handling safety system for allowing an individual to safely open mail and packages. The mail handling safety system includes a container having at least one side wall, an upper portion sealed upon the side wall and a lower opening within the container, a pair of apertures extending into the side wall sufficient in size to receive the arms of an individual, a pair of guides on opposing sides of the apertures, and a door member slidably positioned within the guides for selectively closing the apertures if a contaminated parcel is positioned within the container. The container is comprised of a transparent or semi-transparent material for allowing the user to view the interior of the container. The user places the parcels of mail upon an upper surface of a flat structure and then inserts their hands through the apertures.