Patents by Inventor John I. Peterson
John I. Peterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6867038Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: GrantFiled: February 9, 2001Date of Patent: March 15, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Robert F. Bonner, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 6699721Abstract: A low temperature melt film such as EVA is prepared for laser capture microdissection by having a thin specimen non-adhering coating in the range of 0.1% to 10% of the total film thickness placed on the sample exposed side of the film. When the film is brought into contact with the specimen, the specimen non-adhering coating prevents non-specific transfer due to sticky adherence of portions of the sample. At the same time, the non-adhering coating on the low temperature melt film surface can stabilize and protect the low temperature melt film against variations in performance due to ambient humidity and temperature variation. Upon appropriate heating for laser capture microdissection, the barrier of the thin coating allows conventional film melting with otherwise uninhibited adhesion of selected cell areas to the film.Type: GrantFiled: October 23, 2001Date of Patent: March 2, 2004Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: John I. Peterson, Tristan Gorrindo
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Publication number: 20020037269Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: ApplicationFiled: February 9, 2001Publication date: March 28, 2002Inventors: Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Robert F. Bonner, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 6251516Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: GrantFiled: February 4, 1998Date of Patent: June 26, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert F. Bonner, Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 6251467Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.Type: GrantFiled: July 29, 1999Date of Patent: June 26, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael Emmert-Buck, David B. Krizman, Rodrigo Chuaqui, W. Marston Linehan, Jeffry M. Trent, Robert F. Bonner, Seth R. Goldstein, Paul D. Smith, John I. Peterson
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Patent number: 4792689Abstract: A method for correcting common path variations in intensity in fiber optic chemical sensing devices uses a device for spatially separating light of different wavelength regions and a dye system selected so that light passing back to a measuring system along the fiber optic sensor consists of two wavelength regions. The first wavelength region varies with the concentration of analyte, and the other wavelength region is insensitive to the concentration of analyte.Type: GrantFiled: November 24, 1987Date of Patent: December 20, 1988Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: John I. Peterson
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Patent number: 4544231Abstract: Plastic optical fibers are joined by heat-flaring their ends in a first tubular sleeve and joining the flared ends within a tubular sleeve of about the same size with a U.V.-curable optical cement. The fibers may be joined side-by-side or end-to-end. Different diameter tubes may also be joined together by the method of the present invention.Type: GrantFiled: June 29, 1983Date of Patent: October 1, 1985Assignee: The United States of America as represented by the Secretary of the Department of Health & Human ServicesInventor: John I. Peterson
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Patent number: 4476870Abstract: A fiber optic probe to be implanted in human body tissue for physiologic studies involving measurement and monitoring of the partial pressure of gaseous oxygen in the blood stream, which is coursing through a particular blood vessel in the body. The use of the probe is based on the principle of dye fluorescence oxygen quenching. Structurally the probe comprises two 150-micrometer strands of plastic optical fiber ending in a section of porous polymer tubing serving as a jacket or envelope for the fibers. The tubing is packed with a suitable fluorescent light-excitable dye placed on a porous adsorptive particulate polymeric support. The tubing or jacket is usually made of a hydrophobic, gas-permeable commercial material, known as Celgard, but other suitable hydrophobic gas-permeable material could be used for such structure.Type: GrantFiled: July 7, 1982Date of Patent: October 16, 1984Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: John I. Peterson, Raphael V. Fitzgerald
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Patent number: 4200110Abstract: A fiber optic pH probe suitable to be implanted in tissue for physiological studies is disclosed. The probe includes an ion permeable membrane envelope which encloses the ends of a pair of optical fibers. A pH sensitive dye indicator composition is present within the envelope. The probe operates on the concept of optically detecting the change in color of a pH sensitive dye.Type: GrantFiled: November 28, 1977Date of Patent: April 29, 1980Assignee: United States of AmericaInventors: John I. Peterson, Seth R. Goldstein
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Patent number: 4194877Abstract: The preparation of dye-containing compositions, in which the dye is copolymerized with an acrylic based monomer, is disclosed. A hydrophilic copolymer is formed in which the dye is present in a nondiffusible form. The dye-acrylic polymer composition can be produced in the form of microbeads by emulsion polymerization. In addition, light scattering particles may be added in the form of a material such as polystyrene microspheres.Type: GrantFiled: November 28, 1977Date of Patent: March 25, 1980Assignee: United States of AmericaInventor: John I. Peterson
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Patent number: 3954033Abstract: A method and apparatus for cutting cylinders of gelatinous material such as polyacrylamide gels into discs of precise thickness comprises a cutting surface which is placed in contact with the entire circumference of the cylinder. Cutting force is then applied from all points on the circumference at once, resulting in cutting the gel cylinder towards the center from all points on the circumference. This is accomplished by the use of a multi-bladed diaphragm similar to an iris diaphragm used for camera aperture control. The edges of the blades of the diaphragm form a variable dimension cutting surface.Type: GrantFiled: June 27, 1974Date of Patent: May 4, 1976Assignee: The United States of America as represented by the Secretary of the Department of Health, Education and WelfareInventors: Harold W. Tipton, John I. Peterson