Abstract: Disease states such as cancer or virus infection appear to be dependent on supra-physiological levels of sulfane sulfur. This form of sulfur (sulfane sulfur, zero valent sulfur) has been shown to have numerous biological functions as a growth factor, metabolic regulator, and redox enhancer. It is generated in vivo from the sulfur-containing amino acids methionine and cysteine mainly via the polyamine pathway coupled to cysteine transamination with macrophages acting as an important source. Sulfane sulfur normally binds loosely to sulfur in proteins but it binds tightly to certain agents that have unused electron pairs such as sulfites, nitriles, or phophines. This provides a mechanism for binding and removing disease-related sulfane sulfur. The invention is particularly applicable to Covid-19 because this virus creates a “perfect storm” in which macrophages carry the virus docking site (ACE) and, at the same time, generate the sulfane sulfur required for invasion of the virus.

Abstract: The combination of a cobamide compound, sulfide ion, and glutathione under appropriate conditions leads to the formation of a complex of the three reagents in which sulfur is present as stable persulfide.