Abstract: A system and apparatus is provided to reduce signal routing, area and signal loss in double-pole, double-throw (DPDT) switch implementations in wireless and millimeter-wave front ends. A cyclic staggered arrangement of receivers, transmitters and antenna ports connecting with DPDT switches reduce signal cross-over and allow for compact, low-loss multi-antenna configurations.

Abstract: A method comprising: receiving, at a block device interface, an instruction to write data, the instruction comprising a memory location of the data; copying the data to pinned memory; performing, by a vector processor, one or more invertible transforms on the data; and writing the data from the pinned memory to one or more storage devices asynchronously; wherein the pinned memory of the data corresponds to a location in pinned memory, the pinned memory being accessible by the vector processor and one or more other processors.

Abstract: A method comprising: receiving a request to write data at a virtual location; writing the data to a physical location on a persistent storage device; and recording a mapping from the virtual location to the physical location; wherein the physical location corresponds to a next free block in a sequence of blocks on the persistent storage device.

Abstract: The present invention provides a combination therapy for treatment of a tumour in a subject. The combination therapy comprises administration of (i) an antibody directed against cancer stem cells and (ii) a checkpoint inhibitor.

Abstract: A system and apparatus is provided to reduce signal routing, area and signal loss in double-pole, double-throw (DPDT) switch implementations in wireless and millimeter-wave front ends. A cyclic staggered arrangement of receivers, transmitters and antenna ports connecting with DPDT switches reduce signal cross-over and allow for compact, low-loss multi-antenna configurations.

Abstract: A system and apparatus is provided to reduce signal routing, area and signal loss in double-pole, double-throw (DPDT) switch implementations in wireless and millimeter-wave front ends. A staggered arrangement of receivers, transmitters and antenna ports connecting with DPDT switches reduce signal cross-over and allow for compact, low-loss multi-antenna configurations.

Abstract: A drill reamer (20) comprises an elongate body (21) disposed about a longitudinal axis. The elongate body comprises flutes (22a-22d) having separate hard cutting sections (27a, 28?a, 28?a, 28?b, 28?b) and a soft cutting section (24a, 24b). The soft cutting section is formed of a material such as carbide having a hardness that is less than that of the hard cutting sections, which may be formed of polycrystalline diamond. At least one first hard cutting section (27a) is axially displaced relative to at least one second hard cutting section (28?a, 28?a). The reamer has a tip cutting edge (23a, 23c) and tapered cutting edge portions (24a-24d) disposed at an acute angle relative to the longitudinal axis.

Abstract: A computer implemented method for characterizing one or more sequences by generating index values representing portions of the sequences and finding characterizing index values based on a comparison of the index values. The index values may be obtained by applying one or more mask over each sequence. The modified masks may have associated weightings and index values obtained using modified masks may be retained in the index only if the weightings are above a threshold value. Characterising index values may also be assessed for for their degree of uniqueness. Characterizing indexes may be used for predicting correlation between a sample sequence and one or more reference sequences. Biological monitoring systems utilising the characterizing index values are also disclosed. A biological indicator may be generatgenerated using one or more characterizing index values obtained by the above method and be used to produce an indicator that undergoes a property change in the presence of the one or more sequence.

Abstract: A method of evaluating correlation between sequences by employing a hierarchy of evaluation algorithms. The evaluation algorithms may be arranged in order of computational efficiency as specified by a user or as determined by the system. The algorithms may range from a simple equality algorithm through to seeded alignment algorithms etc. Distributed and parallel processing systems may be employed in the method of the invention in graphical processing units may be employed. The method may be employed with a wide range of sequencers including sequencers produced by Illumina Inc Complete Genomics Inc. and Pacific Biosciences Inc.

Abstract: A system and apparatus is provided to reduce signal routing, area and signal loss in double-pole, double-throw (DPDT) switch implementations in wireless and millimeter-wave front ends. A staggered arrangement of receivers, transmitters and antenna ports connecting with DPDT switches reduce signal cross-over and allow for compact, low-loss multi-antenna configurations.

Abstract: The present invention relates to an innovative method for controlling the viscosity of, for example, adhesives or coating formulations. The method for controlling viscosity allows very rapid thermoplastic curing of a formulation even at room temperature and a significant reduction in the viscosity at higher temperatures, thereby regaining the capacity for simple processing and allowing, for example, the originally bonded substrates to be separated from one another again with ease. A particular aspect in this context is that a plurality of cycles of thermoplastic curing and a significant reduction in the viscosity are possible with the present system.

Abstract: The present invention relates to an innovative method for the reversible crosslinking of, for example, adhesives or coating materials. The reversible crosslinking method allows very rapid crosslinking even at room temperature and undoing of the crosslinks at higher temperatures, thereby regaining the capacity for thermoplastic processing and allowing the originally bonded substrates to be separated from one another again with ease. A particular aspect in this context is that a plurality of cycles of crosslinking and undoing of the crosslinks are possible with the present system.

Abstract: A drill reamer (20) comprises an elongate body (21) disposed about a longitudinal axis. The elongate body comprises flutes (22a-22d) having separate hard cutting sections (27a, 28?a, 28?a, 28?b, 28?b) and a soft cutting section (24a, 24b). The soft cutting section is formed of a material such as carbide having a hardness that is less than that of the hard cutting sections, which may be formed of polycrystalline diamond. At least one first hard cutting section (27a) is axially displaced relative to at least one second hard cutting section (28?a, 28?a). The reamer has a tip cutting edge (23a, 23c) and tapered cutting edge portions (24a-24d) disposed at an acute angle relative to the longitudinal axis.

Abstract: Methods and systems for evaluating genomic sequences are described. The methods include approaches for evaluating the prevalence of genomes in a sample based on the prevalence of segments in the sample, and may additionally rely on the prevalence of segments in reference genomes and an estimated genome population distribution of the sample.

Abstract: A method and system are provided for evaluating the correlation between sequences by entering segments of one sequence in a database and comparing segments of the other sequence with the index values to find correlated segments. The correlated segments are analysed to determine whether the spacing is within a defined range indicating that a correlation threshold has been met. A processing methodology may be employed whereby a coarse potential alignment algorithm is first applied to determine potential alignment at a plurality of potential alignment positions, which are filtered based on alignment scores, and a fine alignment algorithm is then applied.

Abstract: A method of evaluating correlation between sequences by employing a hierarchy of evaluation algorithms. The evaluation algorithms may be arranged in order of computational efficiency as specified by a user or as determined by the system. The algorithms may range from a simple equality algorithm through to seeded alignment algorithms etc. Distributed and parallel processing systems may be employed in the method of the invention in graphical processing units may be employed. The method may be employed with a wide range of sequencers including sequencers produced by Illumina Inc Complete Genomics Inc. and Pacific Biosciences Inc.

Abstract: The present invention relates to an innovative method for the reversible crosslinking of, for example, adhesives or coating materials. The reversible crosslinking method allows very rapid crosslinking even at room temperature and undoing of the crosslinks at higher temperatures, thereby regaining the capacity for thermoplastic processing and allowing the originally bonded substrates to be separated from one another again with ease. A particular aspect in this context is that a plurality of cycles of crosslinking and undoing of the crosslinks are possible with the present system.

Abstract: The present invention relates to an innovative method for controlling the viscosity of, for example, adhesives or coating formulations. The method for controlling viscosity allows very rapid thermoplastic curing of a formulation even at room temperature and a significant reduction in the viscosity at higher temperatures, thereby regaining the capacity for simple processing and allowing, for example, the originally bonded substrates to be separated from one another again with ease. A particular aspect in this context is that a plurality of cycles of thermoplastic curing and a significant reduction in the viscosity are possible with the present system.

Abstract: A method and apparatus route telecommunication calls in a telecommunication switching system by receiving visual information for a caller of one of the telecommunication calls; analyzing the received visual information for characteristics of the telecommunication calls; and routing the one of the telecommunication calls based on the analyzed visual information.

Abstract: A method of improving the water permeability and/or cleaning a porous polymeric membrane (such as a microfiltration or ultrafiltration membrane comprising the step of contacting said a porous polymeric membrane with a source of monopersulfate and a halide ion, such as chloride and optionally a base. The source of monopersulfate may be potassium monopersulfate in conjunction with potassium hydrogen sulfate and potassium sulfate, ie a triple salt of formula 2KHSO5.KHSO4.K2SO4.