Abstract: The present invention is based on the finding that the artificial induction of hepatic stellate cell (HSC) apoptosis in vivo can promote the resolution of liver fibrosis. Thus, the present invention provides methods for treating liver disease in a subject involving administration of an inducer of apoptosis which is capable of selectively inducing hepatic stellate cell apoptosis in the liver of the subject or of an agent which is capable of giving rise to such an inducer in the subject. In addition, the invention provides methods for treating liver fibrosis in a subject comprising the selective delivery of an inducer of apoptosis specifically to the hepatic stellate cells of the subject or of an agent which is capable of giving rise to an inducer of hepatic stellate cell apoptosis.

Abstract: A portable battery powered tone source with a built-in audio cable tester. Plural outputs consist of -40 dB, mic level; -10 dB line level and 1W speaker level. Continuity in the system under test from input to speakers causes an audio frequency signal to be present at speakers. This systems own speakers can be used as monitors in the testing process. Moving the device (source) enables the user to audibly locate the point at which the continuity starts/stops. At such time the user can test the audio castle at that point. The various plugs of the device are compatible with all common audio jacks enabling the user to test all types of audio equipment as well as all types of audio cables with only one device. The device can also be used to test any direct point-to-point connection such as common ground or a PC board run with a simple test lead adaptor.