Abstract: The present invention relates to polynucleotides for use in cancer therapy. In particular, the invention provides a polynucleotide capable of expressing an epilope-&bgr;2m fusion protein; for use in the generation of cytotoxic T lymphocyte (CTL) responses against a tumour, and a polynucleotide capable of expressing an epitope-&bgr;2m fusion protein; for use in a method of restoring antigen presentation in the tumour of a host.

Abstract: The present invention relates to a recombinant soluble T cell receptor. The T cell receptor (TCR) is refolded and comprises a recombinant TCR &agr; or &ggr; chain extracellular domain having a first heterologous C-terminal dimerisation peptide; and a recombinant TCR &bgr; or &dgr; chain extracellular domain having a second C-terminal dimerisation peptide which is specifically heterodimerised with the first dimerisation peptide to form a heterodimerisation domain, which may be a coiled coil domain. The invention also provides nucleic acid sequences encoding the recombinant TCR and a method for producing the recombinant TCR.

Abstract: Independent control of multiple samples which are in close proximity. All the samples in a sample container designed for rapid heat transfer and can be independently regulated to a set point using a temperature feedback control with the temperature monitored by a temperature sensitive element. This is implemented by heating each sample independently and at the same time a cooling device produces a substantial and continuous heat flow from the sample in order to permit an adequate rate of cooling when required. The rate of heat flow through the cooling device is partly determined by a thermal resistance which is included to control the pattern and maximum rate of heat flow to designed levels. By keeping the thermal mass of the temperature controlled components to a minimum it is also possible to change the temperature of the samples very rapidly.