Abstract: In one aspect, the present disclosure describes tetrahydropyridine compounds of formula (I), which are 5-HT2A receptor agonists that exhibit selective binding to the 5-HT2A receptor over the 5-HT2B receptor. In certain embodiments, the compound of formula (I) is a compound of formula (II). Also provided herein are methods of treating, ameliorating, and/or preventing neurological diseases and disorders with compounds of formula (II).

Abstract: A clip applier jaw assembly and processes for manufacturing a clip applier jaw are described. The clip applier jaw assembly includes a first jaw and a second jaw joined to the first jaw. The first and second jaws are independently formed and subsequently joined. A progressive stamping process can be used to form each of the first and second jaws by cutting a compound cut in a sheet of material, deburring the cut jaw blank with an edge coining process, and coining a clip groove in the jaw blank. A second jaw can be formed using the same process in a die configured to produce a mirror image of the first jaw. The first and second jaws can be joined by a welding process.

Abstract: Method of operating an environment management system within a building uses each of at least a first and a second model to predict, for a chosen time period ahead, one or both of: i) control requirements for the environment management system in light of a current measured system state and a desired future system state or ii) a future system state that would be reached with a particular set of control inputs. The first model is a parameterised physical model of the building and the second model is an implicit model of the building. Prediction models are evaluated, a band of uncertainty determined, and a control strategy that minimizing a likely level of deviation from the desired future system state selected. The control strategy comprises control parameters for the environment management system. The environment management system controls the environment in the building in accordance with the selected control strategy.

Abstract: A method and system for validating components during a booting process of a computing device are described herein. The method can include the steps of detecting a power up signal and in response to detecting the power up signal, progressively determining whether software components of the computing device are valid. If the software components are determined to be valid, the computing device may be permitted to move to an operational state. If, however, at least some of the software components are determined to be not valid, the computing device may be prevented from moving to the operational state. In one arrangement, if the computing device is prevented from moving to the operational state, corrective action can be taken in an effort to permit the computing device to move to the operational state.

Abstract: Disclosed here are methods, systems, paradigms and structures for spreading the interest of a user evenly over a predefined set of search results. A search engine retrieves search results from a database and perturbs at least a portion of the search results, that is, randomizes the order of the portion before presenting it to the user. In this way, even when a search is repeated between database update cycles, the user would see different top search results every time the search is executed. The perturbation technique can be applied to a search in a social networking system which searches for users. The perturbation can be done by randomizing the display order of the sear results based on a most recent activity time of the user. The perturbed search results will have different users every time the user performs a search. The perturbed search results are customized per user.

Abstract: The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.

Abstract: A method and system for validating components during a booting process of a computing device are described herein. The method can include the steps of detecting a power up signal and in response to detecting the power up signal, progressively determining whether software components of the computing device are valid. If the software components are determined to be valid, the computing device may be permitted to move to an operational state. If, however, at least some of the software components are determined to be not valid, the computing device may be prevented from moving to the operational state. In one arrangement, if the computing device is prevented from moving to the operational state, corrective action can be taken in an effort to permit the computing device to move to the operational state.

Abstract: A method and system for validating components during a booting process of a computing device are described herein. The method can include the steps of detecting a power up signal and in response to detecting the power up signal, progressively determining whether software components of the computing device are valid. If the software components are determined to be valid, the computing device may be permitted to move to an operational state. If, however, at least some of the software components are determined to be not valid, the computing device may be prevented from moving to the operational state. In one arrangement, if the computing device is prevented from moving to the operational state, corrective action can be taken in an effort to permit the computing device to move to the operational state.

Abstract: Disclosed here are methods, systems, paradigms and structures for spreading the interest of a user evenly over a predefined set of search results. A search engine retrieves search results from a database and perturbs at least a portion of the search results, that is, randomizes the order of the portion before presenting it to the user. In this way, even when a search is repeated between database update cycles, the user would see different top search results every time the search is executed. The perturbation technique can be applied to a search in a social networking system which searches for users. The perturbation can be done by randomizing the display order of the sear results based on a most recent activity time of the user. The perturbed search results will have different users every time the user performs a search. The perturbed search results are customized per user.

Abstract: The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.

Abstract: A magazine well insert prevents contaminants from entering the magazine well of a pistol or a rifle. The magazine well insert provides a visual indication that the weapon does not have a magazine installed, thereby enhancing weapons safety. The magazine well insert of the present invention protects the weapon's magazine well from becoming contaminated with sand and other debris by sealing the magazine well with a block, for example, a plastic or metal block, that has an o-ring or other sealing device adapted to be positioned at the opening of the magazine well. The magazine well insert may be used in two different configurations, a first configuration that allow normal operation of the weapon's action or a second configuration that blocks the action of the weapon. The magazine well insert may be hollow with a removable sliding base to provide for storage in an interior portion thereof.

Abstract: A magazine well insert prevents contaminants from entering the magazine well of a pistol or a rifle. The magazine well insert provides a visual indication that the weapon does not have a magazine installed, thereby enhancing weapons safety. The magazine well insert of the present invention protects the weapon's magazine well from becoming contaminated with sand and other debris by sealing the magazine well with a block, for example, a plastic or metal block, that has an o-ring or other sealing device adapted to be positioned at the opening of the magazine well. The magazine well insert may be used in two different configurations, a first configuration that allow normal operation of the weapon's action or a second configuration that blocks the action of the weapon. The magazine well insert may be hollow with a removable sliding base to provide for storage in an interior portion thereof.

Abstract: A tray assembly including a tray having a base, a pair of side walls spaced apart between a pair of end walls, the walls extending away from the base to define a space to receive material to be towed; the tray being supported by a frame, the frame having a pair of side rails spaced apart between a pair of end rails to form a generally rectangular shape, the frame includes a carriage to mount said frame to a structure. Each side rail having a series of spaced apart rollers adapted to engage corresponding guides located on said tray, respective rollers and guides are operatively associated with each other to assist movement of said tray with respect to said frame.

Abstract: A method of translating raw formatted IR codes to discrete formatted IR codes. A raw formatted IR message representing an IR code can be detected. The IR message can include a raw formatted device ID including a first series of IR pulses and a raw formatted command ID including a second series of IR pulses. The IR message can be encoded into a definition that defines the first and second series of pulses contained in the IR message. Encoded data corresponding to the device ID and the command ID can be identified. The encoded data corresponding to the device ID can be matched to a particular device to identify a discrete formatted device ID. The encoded data corresponding to the command ID can be matched to a particular command to identify a discrete formatted command ID. The discrete formatted device ID and the discrete formatted command ID can be stored.

Abstract: A method and system for validating components during a booting process of a computing device are described herein. The method can include the steps of detecting a power up signal and in response to detecting the power up signal, progressively determining whether software components of the computing device are valid. If the software components are determined to be valid, the computing device may be permitted to move to an operational state. If, however, at least some of the software components are determined to be not valid, the computing device may be prevented from moving to the operational state. In one arrangement, if the computing device is prevented from moving to the operational state, corrective action can be taken in an effort to permit the computing device to move to the operational state.

Abstract: A magazine well insert prevents contaminants from entering the magazine well of a pistol or a rifle. The magazine well insert provides a visual indication that the weapon does not have a magazine installed, thereby enhancing weapons safety. The magazine well insert of the present invention protects the weapon's magazine well from becoming contaminated with sand and other debris by sealing the magazine well with a block, for example, a plastic or metal block, that has an o-ring or other sealing device adapted to be positioned at the opening of the magazine well. The magazine well insert may be used in two different configurations, a first configuration that allow normal operation of the weapon's action or a second configuration that blocks the action of the weapon. The magazine well insert may be hollow with a removable sliding base to provide for storage in an interior portion thereof.

Abstract: A method of translating raw formatted IR codes to discrete formatted IR codes. A raw formatted IR message representing an IR code can be detected. The IR message can include a raw formatted device ID including a first series of IR pulses and a raw formatted command ID including a second series of IR pulses. The IR message can be encoded into a definition that defines the first and second series of pulses contained in the IR message. Encoded data corresponding to the device ID and the command ID can be identified. The encoded data corresponding to the device ID can be matched to a particular device to identify a discrete formatted device ID. The encoded data corresponding to the command ID can be matched to a particular command to identify a discrete formatted command ID. The discrete formatted device ID and the discrete formatted command ID can be stored.

Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.

Abstract: A medical lancing device including a replaceable multi-lancet cartridge. The lancing device includes an advancing mechanism that advances lancets within the cartridge into an active position, separates a protective cap from the active lancet, and energize a drive mechanism of the lancing device. A cap displacement mechanism moves the separated cap out of the travel path of the active lancet. In a first example embodiment, the cap displacement mechanism includes a cantilevered spring arm that displaces the detached cap of the active lancet. In a second example embodiment, the cap displacement mechanism includes a spring-biased cam-driven plunger that displaces the detached cap of the active lancet. Then an activation mechanism releases the energized active lancet to traverse the unobstructed lancing stroke path to pierce the subject's skin at a desired lancing site.

Abstract: A medical lancing device including a replaceable multi-lancet cartridge. The lancing device includes an advancing mechanism that advances lancets within the cartridge into an active position, separates a protective cap from the active lancet, and energize a drive mechanism of the lancing device. A cap displacement mechanism moves the separated cap out of the travel path of the active lancet. In a first example embodiment, the cap displacement mechanism includes a cantilevered spring arm that displaces the detached cap of the active lancet. In a second example embodiment, the cap displacement mechanism includes a spring-biased cam-driven plunger that displaces the detached cap of the active lancet. Then an activation mechanism releases the energized active lancet to traverse the unobstructed lancing stroke path to pierce the subject's skin at a desired lancing site.