Abstract: This invention relates to methods for separating, isolating and/or enriching extracellular matrix bodies in a biological fluid. More particularly, this invention discloses methods for isolating and detecting extracellular matrix bodies from a biological sample as medical information and/or for use in diagnosis and prognosis of disease. The methods include immuno-affinity capture of extracellular matrix bodies.

Abstract: This invention relates to methods for separating, isolating and/or enriching extracellular matrix bodies in a biological fluid. More particularly, this invention discloses methods for isolating and detecting extracellular matrix bodies from a biological sample as medical information and/or for use in diagnosis, prognosis and monitoring disease.

Abstract: In one aspect, the present disclosure describes tetrahydropyridine compounds of formula (I), which are 5-HT2A receptor agonists that exhibit selective binding to the 5-HT2A receptor over the 5-HT2B receptor. In certain embodiments, the compound of formula (I) is a compound of formula (II). Also provided herein are methods of treating, ameliorating, and/or preventing neurological diseases and disorders with compounds of formula (II).

Abstract: A clip applier jaw assembly and processes for manufacturing a clip applier jaw are described. The clip applier jaw assembly includes a first jaw and a second jaw joined to the first jaw. The first and second jaws are independently formed and subsequently joined. A progressive stamping process can be used to form each of the first and second jaws by cutting a compound cut in a sheet of material, deburring the cut jaw blank with an edge coining process, and coining a clip groove in the jaw blank. A second jaw can be formed using the same process in a die configured to produce a mirror image of the first jaw. The first and second jaws can be joined by a welding process.

Abstract: Disclosed here are methods, systems, paradigms and structures for spreading the interest of a user evenly over a predefined set of search results. A search engine retrieves search results from a database and perturbs at least a portion of the search results, that is, randomizes the order of the portion before presenting it to the user. In this way, even when a search is repeated between database update cycles, the user would see different top search results every time the search is executed. The perturbation technique can be applied to a search in a social networking system which searches for users. The perturbation can be done by randomizing the display order of the sear results based on a most recent activity time of the user. The perturbed search results will have different users every time the user performs a search. The perturbed search results are customized per user.

Abstract: The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.

Abstract: Disclosed here are methods, systems, paradigms and structures for spreading the interest of a user evenly over a predefined set of search results. A search engine retrieves search results from a database and perturbs at least a portion of the search results, that is, randomizes the order of the portion before presenting it to the user. In this way, even when a search is repeated between database update cycles, the user would see different top search results every time the search is executed. The perturbation technique can be applied to a search in a social networking system which searches for users. The perturbation can be done by randomizing the display order of the sear results based on a most recent activity time of the user. The perturbed search results will have different users every time the user performs a search. The perturbed search results are customized per user.

Abstract: The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.

Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.

Abstract: A medical lancing device including a replaceable multi-lancet cartridge. The lancing device includes an advancing mechanism that advances lancets within the cartridge into an active position, separates a protective cap from the active lancet, and energize a drive mechanism of the lancing device. A cap displacement mechanism moves the separated cap out of the travel path of the active lancet. In a first example embodiment, the cap displacement mechanism includes a cantilevered spring arm that displaces the detached cap of the active lancet. In a second example embodiment, the cap displacement mechanism includes a spring-biased cam-driven plunger that displaces the detached cap of the active lancet. Then an activation mechanism releases the energized active lancet to traverse the unobstructed lancing stroke path to pierce the subject's skin at a desired lancing site.

Abstract: A medical lancing device including a replaceable multi-lancet cartridge. The lancing device includes an advancing mechanism that advances lancets within the cartridge into an active position, separates a protective cap from the active lancet, and energize a drive mechanism of the lancing device. A cap displacement mechanism moves the separated cap out of the travel path of the active lancet. In a first example embodiment, the cap displacement mechanism includes a cantilevered spring arm that displaces the detached cap of the active lancet. In a second example embodiment, the cap displacement mechanism includes a spring-biased cam-driven plunger that displaces the detached cap of the active lancet. Then an activation mechanism releases the energized active lancet to traverse the unobstructed lancing stroke path to pierce the subject's skin at a desired lancing site.

Abstract: A lancing device and a removable and replaceable multi-lancet cartridge for use in connection therewith are disclosed. The multi-lancet cartridge is advanced through sequential lancets, and anti-reverse features prevent reverse advancement of the cartridge. Interlocks are provided to prevent double-cocking the device, to reduce the likelihood of jamming of the mechanism. Improved trigger mechanisms and depth control mechanisms are provided.

Abstract: A low-pain lancing device includes a drive mechanism for loosely engaging a lancet and driving the lancet along an axial path. The drive mechanism has a first coupling element and the lancet has a second coupling element, which together form a loose coupling therebetween, wherein interaction between the first and second coupling elements permits a degree of freedom of movement between the lancet and the drive mechanism in a lateral direction, perpendicular to the axial path of travel of the lancet, to prevent non-axial movement of the lancet tip during lancing and thereby reduce pain experienced by the subject.

Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.

Abstract: A method and system for reputation-based resource allocation for networking. The present invention provides a method for determining an allocation of a plurality of computer resources based on a reputation factor for each of the one ore more clients. Clients associated with bad reputation factors may be denied or delayed from computer resources. According to an embodiment, the method is used in a computer network environment wherein one or more clients share a plurality of computer resources. The method includes a step of providing a network appliance. The network appliance includes one or more memories and a central processing unit. The networking appliance has at least a first port and a second port. The first port and the second port exchanges a stream of information. The network appliance is characterized by a limited quantity of system resources. The method also includes a step for processing the stream of network traffic.

Abstract: Methods and systems for low-latency event pipelining. According to an embodiment, the present invention provides a method for reducing a latency associated with the stream of information passes through the virtual pipeline. The method is performed in a network system, wherein a stream of information passes through a virtual pipeline of a plurality of modules. The method includes a step for receiving the stream of information from a first network portion at a first time to define an initiation time. The method includes a step for processing the stream of information into a plurality of events. The plurality of events includes a first event and a second event. The method includes a step for processing the first event in a first format at a first module of the plurality of modules to determine if the first event is passed to a second module, redirected to another process, or changed to the first event in a second format, or not passed.

Abstract: A lancing device and replaceable multi-lancet cartridge for use in sampling of body fluids. Sequential lancets of the cartridge are translationally retracted along a storage path, pivoted into an angularly offset firing path, and translationally propelled by a drive mechanism to lance the subject's skin.

Abstract: A sampling device (20) having a housing (24) with a lancet cartridge (22) mounted therein. The lancets (26) of the lancet cartridge (22) are interconnected by a flexible web (28). The lancet cartridge (22) is not positively engaged within the housing (24) and can be easily removed. The housing (24) has an opening (42) with an adjacent flexible or compressible fin (60) for dampening the motion of the lancet (26). The lancet cartridge (22) has at least one lancet (26) with an endcap, and the housing has a cap-removal mechanism (74) for separating the endcap from the housing (24). Anti-tampering features prevent opening of the device when the lancet cartridge (22) is oriented with a lancet (26) in a firing position.

Abstract: A sampling device having a lancing apparatus, and optionally a detector and a meter. The lancing apparatus includes a replaceable cartridge of lancets, each lancet having an independent arming and drive mechanism enabling non-sequential and/or simultaneous firing of lancets. A lancet retainer independently associated with each lancet is movable to uncover an opening through which the lancet tip passes, and to release the lancet for activation. The lancets can be actuated in any order, and multiple lancets can be simultaneously actuated, if desired.

Abstract: A local link partner accesses in-band the management registers of a remote link partner. The local link partner generates and transmits a management message formatted according to a predefined communication protocol, under the direction of a network management system. The management message is generated according to a message template reserved by the predefined protocol for customization. The management message is transmitted in-band from the local link partner to the remote link partner. The management message can be transmitted when the local link partner is in an active mode or in an idle mode, as defined by the predefined communication protocol. The management message contains a first portion that identifies itself as a message reserved by the predefined protocol for customization. A second portion of the management message contains a management command. The remote link partner performs the management command, which can be a register read or write.