Abstract: The invention generally relates to dosage regimes of anti-Cluster of Differentiation 73 (CD73) antibodies and/or anti-ectoenzyme ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) antibodies, used in methods of treatment of cancer in a subject, as well as dosage regimes of anti-CD73 antibodies for use in treating cancer. The invention further generally relates to dosage regimes of combinations of agents, such as combinations comprising anti-CD73 antibodies and/or anti-ENTPD2 antibodies and at least one or more of a PD-1 inhibitor, and an adenosine A2AR antagonist.

Abstract: A handheld vacuum cleaner includes a dirt separator. The dirt separator includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The dirt-laden fluid enters the chamber along a flow axis that intersects the disc.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The dirt-laden fluid enters the chamber along a flow axis that intersects the disc.

Abstract: The present disclosure provides methods related to accurate detection and treatment of medical conditions related to Clostridioides difficile infection (CDI). In specific cases, the disclosure concerns accurate assessment of a symptom associated with CDI related to the presence or risk that may or may not be a pathogenic infection. Particular embodiments encompass detection of one or more specific analytes that provide information for accurate diagnosis and treatment of CDI.

Abstract: Novel distractorless authorship verification technology optionally combines with novel algorithms to solve authorship attribution as to an open set of candidates—such as without limitation by analyzing the voting of “mixture of experts” and outputting the result to a user using the following: if z (z=pi?pj? pi+pj?(pi?pj)2/n) is larger than a first predetermined threshold then author j cannot be the correct author; or if z (z=pi?pj? pi+pj?(pi?pj)2/n) is smaller than a second predetermined threshold then author i cannot be the correct author; or if no author garners significantly more votes than all other contenders then none of the named authors is the author of a document in question—in a number of novel applications. Personality profiling and authorship attribution may also be used to verify user identity to a computer.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The inlet is defined by an end of an inlet duct that extends within the chamber, and a separation distance between the centre of the inlet and the centre of the disc is no greater than the diameter of the inlet.

Abstract: A cleaner head for a vacuum cleaner includes a suction cavity comprising an opening through which debris enters the cleaner head, and an outlet. An agitator is mounted in the suction cavity in a cantilevered manner for rotation relative thereto. The agitator includes a core having a first, free end, a second end remote from the free end, and upstanding helical ridges extending between the free end and the second end, and a row of bristles located between the helical ridges and inclined relative to the core in a direction extending towards the free end of the core.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The dirt-laden fluid enters the chamber along a flow axis that intersects the disc.

Abstract: An application licensing system reduces the computational cost of providing application access to licensees by running instances of licensed applications in virtual machines and providing web-based user interfaces to client devices associated with users of a license pool. An application licensing system onboards one or more licenses for applications licensed by an organization from an application vendor. When a user of the organization wishes to access a licensed application, the application licensing system determines whether the organization's license pool permits the requested use and analyzes current uses of the requested application to determine whether a license is available for use by the user. If the set of application licenses for the organization permits the requested use, the system runs an instance of the application in a virtual machine and provides the user with access to the application through a web-based user interface.

Abstract: Certain embodiments of the present invention relate to methods and products for use in the determination of treatment of rheumatoid arthritis (RA). Particularly, although not exclusively, embodiments of the present invention relate to predicting the likelihood of a patient suffering from rheumatoid arthritis maintaining remission following cessation of disease-modifying anti-rheumatic drugs (DMARDs). Certain embodiments of the present invention are based on the determination of certain biomarkers of drug-free remission in RA following cessation of DMARD therapy.

Abstract: Novel distractorless authorship verification technology optionally combines with novel algorithms to solve authorship attribution as to an open set of candidates—such as without limitation by analyzing the voting of “mixture of experts” and outputting the result to a user using the following: if z (z=pi?pj? pi+pj?(pi?pj)2/n) is larger than a first predetermined threshold then author j cannot be the correct author; or if z (z=pi?pj? pi+pj?(pi?pj)2/n) is smaller than a second predetermined threshold then author i cannot be the correct author; or if no author garners significantly more votes than all other contenders then none of the named authors is the author of a document in question—in a number of novel applications. Personality profiling and authorship attribution may also be used to verify user identity to a computer.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The inlet is defined by an end of an inlet duct, and at least a portion of the inlet duct comprising the inlet extends within the chamber along an axis coincident the rotational axis.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis, and including holes running from an upstream face to a downstream face through which the cleansed fluid passes. Each hole has a tapered portion which narrows from an upstream end to a downstream end thereof.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The disc comprises a perforated region and a non-perforated region. The holes are then formed in the perforated region, and the width of the non-perforated region is no less than the diameter of the inlet.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. A wall of the chamber is moveable between an open position and a closed position, and the inlet is defined by an end of an inlet duct attached to and moveable with the wall.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis and including holes through which the cleansed fluid passes. When viewed normal to the disc, each hole is elongate and defines a longitudinal axis which runs within the plane of the disc. The longitudinal axis of each hole is curved.

Abstract: A dirt separator for a vacuum cleaner including a chamber having an inlet through which dirt-laden fluid enters the chamber and an outlet through which cleansed fluid exits the chamber; and a disc located at the outlet, the disc being arranged to rotate about a rotational axis and including holes through which the cleansed fluid passes. When viewed normal to the disc, each hole is elongate and defines a longitudinal axis which runs within the plane of the disc. The longitudinal axis of each hole is inclined relative to the radial direction of the disc.

Abstract: A dirt separator for a vacuum cleaner includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes. The inlet is defined by an end of an inlet duct that extends within the chamber, and a separation distance between the centre of the inlet and the centre of the disc is no greater than the diameter of the inlet.