Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A Multi-Purpose Dynamic Simulation and run-time Control platform includes a virtual process environment coupled to a physical process environment, where components/nodes of the virtual and physical process environments cooperate to dynamically perform run-time process control of an industrial process plant and/or simulations thereof. Virtual components may include virtual run-time nodes and/or simulated nodes. The MPDSC includes an I/O Switch which delivers I/O data between virtual and/or physical nodes, e.g., by using publish/subscribe mechanisms, thereby virtualizing physical I/O process data delivery. Nodes serviced by the I/O Switch may include respective component behavior modules that are unaware as to whether or not they are being utilized on a virtual or physical node. Simulations may be performed in real-time and even in conjunction with run-time operations of the plant, and/or simulations may be manipulated as desired (speed, values, administration, etc.).

Abstract: A Multi-Purpose Dynamic Simulation and run-time Control platform includes a virtual process environment coupled to a physical process environment, where components/nodes of the virtual and physical process environments cooperate to dynamically perform run-time process control of an industrial process plant and/or simulations thereof. Virtual components may include virtual run-time nodes and/or simulated nodes. The MPDSC includes an I/O Switch which delivers I/O data between virtual and/or physical nodes, e.g., by using publish/subscribe mechanisms, thereby virtualizing physical I/O process data delivery. Nodes serviced by the I/O Switch may include respective component behavior modules that are unaware as to whether or not they are being utilized on a virtual or physical node. Simulations may be performed in real-time and even in conjunction with run-time operations of the plant, and/or simulations may be manipulated as desired (speed, values, administration, etc.).

Abstract: In one embodiment, a translation gateway is for use between a network of a messaging service provider and a hostile data network. The gateway is to forward messages using a secure connection through the hostile network, to a customer's network. Different types of inbound messages (e.g., voice; fax) can be delivered to a single client process running on a customer machine on the customer network. In addition, the translation gateway may be used to securely forward different types of outbound messages originating from the client process to the service provider's network (where the messages are retransmitted as voice calls or facsimiles into a telephone network). Other embodiments are also described and claimed.

Abstract: In one embodiment, a translation gateway is for use between a network of a messaging service provider and a hostile data network. The gateway is to forward messages using a secure connection through the hostile network, to a customer's network. Different types of inbound messages (e.g., voice; fax) can be delivered to a single client process running on a customer machine on the customer network. In addition, the translation gateway may be used to securely forward different types of outbound messages originating from the client process to the service provider's network (where the messages are retransmitted as voice calls or facsimiles into a telephone network). Other embodiments are also described and claimed.

Abstract: In one embodiment, a translation gateway is for use between a network of a messaging service provider and a hostile data network. The gateway is to forward messages using a secure connection through the hostile network, to a customer's network. Different types of inbound messages (e.g., voice; fax) can be delivered to a single client process running on a customer machine on the customer network. In addition, the translation gateway may be used to securely forward different types of outbound messages originating from the client process to the service provider's network (where the messages are retransmitted as voice calls or facsimiles into a telephone network). Other embodiments are also described and claimed.

Abstract: In one embodiment, a translation gateway is for use between a network of a messaging service provider and a hostile data network. The gateway is to forward messages using a secure connection through the hostile network, to a customer's network. Different types of inbound messages (e.g., voice; fax) can be delivered to a single client process running on a customer machine on the customer network. In addition, the translation gateway may be used to securely forward different types of outbound messages originating from the client process to the service provider's network (where the messages are retransmitted as voice calls or facsimiles into a telephone network). Other embodiments are also described and claimed.

Abstract: In one embodiment, a translation gateway is for use between a network of a messaging service provider and a hostile data network. The gateway is to forward messages using a secure connection through the hostile network, to a customer's network. Different types of inbound messages (e.g., voice; fax) can be delivered to a single client process running on a customer machine on the customer network. In addition, the translation gateway may be used to securely forward different types of outbound messages originating from the client process to the service provider's network (where the messages are retransmitted as voice calls or facsimiles into a telephone network). Other embodiments are also described and claimed.

Abstract: In one embodiment, a translation gateway is for use between a network of a messaging service provider and a hostile data network. The gateway is to forward messages using a secure connection through the hostile network, to a customer's network. Different types of inbound messages (e.g., voice; fax) can be delivered to a single client process running on a customer machine on the customer network. In addition, the translation gateway may be used to securely forward different types of outbound messages originating from the client process to the service provider's network (where the messages are retransmitted as voice calls or facsimiles into a telephone network). Other embodiments are also described and claimed.

Abstract: A marine macerator switch including a comparator programmable with over and under current limits corresponding with the characteristics of a macerator drive motor. A sensing circuit senses the real time motor current and compares it with the current limits to, at respective predetermined differentials, shut the motor down. The control also includes a timer programmed to allow the motor to run for a period of time corresponding with that required for emptying of the tank.

Abstract: A marine macerator switch including a comparator programmable with over and under current limits corresponding with the characteristics of a macerator drive motor. A sensing circuit senses the real time motor current and compares it with the current limits to, at respective predetermined differentials, shut the motor down. The control also includes a timer programmed to allow the motor to run for a period of time corresponding with that required for emptying of the tank.