Patents by Inventor John J. Bissler
John J. Bissler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7857976Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.Type: GrantFiled: October 19, 2009Date of Patent: December 28, 2010Assignee: Children's Hospital Medical CenterInventors: John J. Bissler, Marios M. Polycarpou, Nat Hemasilpin, Efrain O. Morales
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Patent number: 7785463Abstract: A system, program product and method continuously optimize an ultrafiltration rate during an extracorporeal renal replacement process by modeling physiological and actual rate data. The system maps the sensed, physiological data to a mathematical model to assess the data in terms of the ultrafiltration rate. The model provides parameters used to predict where the treatment is headed based on current conditions. The system processes the parameters in terms of preset criteria to generate the optimized ultrafiltration rate. Where the system is networked, communication of the data may be accomplished using remote and online communication techniques.Type: GrantFiled: March 17, 2006Date of Patent: August 31, 2010Assignee: Children's Hospital Medical CenterInventors: John J. Bissler, Nat Hemasilpin, Marios M. Polycarpou
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Publication number: 20100038317Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.Type: ApplicationFiled: October 19, 2009Publication date: February 18, 2010Applicant: CHILDREN'S HOSPITAL MEDICAL CENTERInventors: John J. Bissler, Marios M. Polycarpou, Nat Hemasilpin, Efrain O. Morales
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Patent number: 6780322Abstract: A multipurpose hemofiltration system (10) and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system (10) continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller (160) can monitor patient parameters, such as heart rate (120) and blood pressure (130), and adjust the pumping rates accordingly. The supervisory controller (160) uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller (162) corrects temporal variations in the flow rate based upon an adaptive law and a control law.Type: GrantFiled: June 11, 2002Date of Patent: August 24, 2004Assignee: Children's Hospital Medical CenterInventors: John J. Bissler, Marios M. Polycarpou, Nat Hemasilpin, Efrain O. Morales
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Patent number: 6471872Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters.Type: GrantFiled: March 10, 1997Date of Patent: October 29, 2002Assignee: Children's Hospital Medical CenterInventors: Yuli Kitaevich, Nat Hemasilpin, J. Gabriel Marchevsky, John J. Bissler, George Benzing, III, Paul T. McEnery
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Publication number: 20010045395Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters.Type: ApplicationFiled: March 10, 1997Publication date: November 29, 2001Applicant: YULI KITAEVICHInventors: YULI KITAEVICH, NAT HEMASILPIN, J. GABRIEL MARCHEVSKY, JOHN J. BISSLER, GEORGE BENZING, PAUL T. MCENERY
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Patent number: 6200485Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters.Type: GrantFiled: March 4, 1999Date of Patent: March 13, 2001Assignee: Chidren's Hospital Medical CenterInventors: Yuli Kitaevich, Nat Hemasilpin, J. Gabriel Marchevsky, John J. Bissler, George Benzing, III, Paul T. McEnery
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Patent number: 5344568Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.Type: GrantFiled: May 17, 1993Date of Patent: September 6, 1994Assignee: Children's Hospital Medical CenterInventors: Yuli Kitaevich, Nat Hemasilpin, J. Gabriel Marchevsky, John J. Bissler, George Benzing, III, Paul T. McEnery
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Patent number: 5211849Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.Type: GrantFiled: October 11, 1991Date of Patent: May 18, 1993Assignee: Children's Hospital Medical CenterInventors: Yuli Kitaevich, Nat Hemasilpin, J. Gabriel Marchevsky, John J. Bissler, George Benzing, III, Paul T. McEnery