Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: In an electrical system of the type in which a digitally-encoded signal is determined at least in part by the difference between a present value of an analog input signal and a reconstructed signal representative of a past value of the input signal and including signal generating means for generating said reconstructed signal, which means is responsive to a reference signal, improved circuitry for generating the reference signal. The improved circuitry comprises a ladder network which increases the magnitude of the reference signal as a function of the length of time the digitally-encoded signal continuously remains in either digital state without a change to the other digital state.

Abstract: In an electrical system of the type in which a digitally-encoded signal is determined at least in part by the difference between a present value of an input signal and a reconstructed signal representative of a past value of the input signal and including a filter for extracting from the digital signal information relating to the time derivative of the input signal, peak detection means for determining the peak value of the output of said filter, and a signal generating means responsive to a reference signal determined from the output of said peak detection means for generating the reconstructed signal, improved circuitry for generating the reference signal. The circuit comprises weighting means for increasing the magnitude of the input to the filter as a function of the preponderance of one or the other state in said digitally-encoded signal.

Abstract: In an electrical system of the type in which a digitally-encoded signal is determined at least in part by the difference between a present value of an input signal and a reconstructed signal representative of a past value of the input signal and including a filter for extracting from the digital signal information relating to the time derivative of the input signal, peak detection means for determining the peak value of the output of said filter, and a signal generating means responsive to a reference signal determined from the output of said peak detection means for generating the reconstructed signal, improved circuitry for generating the reference signal. The circuit comprises weighting means for increasing the magnitude of the input to the filter as a function of the preponderance of one or the other state in said digitally-encoded signal.