Abstract: The present disclosure is directed to methods for reducing cardiovascular risk in a human subject by administering atrasentan, or a pharmaceutically acceptable salt thereof, in an amount sufficient to effect a reduction of about 5% or more in one or both of (a) total serum cholesterol, relative to the subject's baseline total serum cholesterol, and (b) serum LDL cholesterol, relative to the subject's baseline serum LDL cholesterol.

Abstract: The present disclosure provides compositions and methods for treating multidrug-resistant nephrotic syndrome (MDR-NS) in pediatric subjects comprising atrasentan. Methods of reducing protenuria in a pediatric patient having MDR-NS are also provided.

Abstract: The present invention relates to compositions for treating prepubertal males of adolescent age with insufficient testosterone production using a hydroalcoholic testosterone gel formulation that provides, among other things, a desirable pharmacokinetic hormone profile, and methods of treating said adolescent males.

Abstract: A method for purifying a precursor material for use in a chemical vapor deposition system comprising providing a precursor material suitable for chemical vapor deposition, and distilling the precursor material to provide, as a distillate, a purified precursor material from which at least one non-volatile component, at least one metal impurity, or a combination thereof has been removed. The method may be used to purify siloxane and silane precursor materials and reduce clogging of chemical vapor deposition components.

Abstract: A barrier layer for a silicon containing substrate comprises an alkaline earth aluminosilcate and an additive component capable of forming a reaction product with silica.

Abstract: An apparatus for the semi-automatic feeding of piglets up to 21 days old, comprises an open feeding trough which is supplied with liquid feed in predetermined quantities at predetermined intervals. The inlet to the feed trough is disposed substantially centrally along the length of the trough, in the vicinity of a raised area of the trough, so that the feed distributes itself to the end of the trough under gravity. The strong, dominant animal of the group automatically makes to feed from the trough vicinity of the feed inlet, and the sloping arrangement of the trough ensures that the smaller, weaker animals obtain an adequate supply of feed. The trough surface is smooth and essentially free from crevices, recesses and the like, so that it is essentially cleaned by the feeding piglets themselves.

Abstract: Chemical vapor deposition (CVD) techniques for forming tough silicon carbide (SiC) matrix composites. The introduction of methyldichlorosilane (MDS) to a reactor containing a fiber preform which been flushed with a noble gas, causes the formation of a carbon layer around the fibers. The carbon interlayer improves the fracture toughness of the composite.

Abstract: A silicon carbide fiber reinforced glass-ceramic matrix composite article is disclosed. The matrix is a lithium alumino silicate glass-ceramic composition which may include from 1 to 5 weight percent B.sub.2 O.sub.3. The fiber reinforced glass-ceramic matrix composite article exhibits both high flexural strength at elevated temperatures and oxidative stability at elevated temperatures in an oxidizing environment.

Abstract: High strength, fracture tough, high temperature oxidatively stable, gas turbine engine core engine components are described made of silicon carbide fiber reinforced ceramic matrix or silicon carbide fiber reinforced glass matrix material. A gas turbine engine containing core engine components as above described is also disclosed.

Abstract: A composite material suitable for use as an abradable seal is described. The seal comprises a high temperature stable fiber reinforced glass or glass-ceramic matrix base having at least one layer of abradable ceramic material, plasma sprayed or bonded to it. The ceramic abradable layer has a working temperature up to at least 3000.degree. F. (1648.degree. C.) and is oxidatively stable. The abradable seal has particular utility in a gas turbine engine.

Abstract: High strength, fracture tough, high temperature oxidatively stable, gas turbine engine core engine components are described made of silicon carbide fiber reinforced ceramic matrix or silicon carbide fiber reinforced glass matrix material. A gas turbine engine containing core engine components as above described is also disclosed.

Abstract: A silicon carbide fiber reinforced barium modified magnesium aluminosilicate matrix composite is described having high strength and thermal stability at temperatures in excess of 1200.degree. C. The matrix material contains about 5% to about 14% magnesium oxide and about 5% to about 25% barium oxide. While any suitable ratios of fiber to matrix can be used, the composite for most applications for example, in the heat engine area, will contain approximately 20% to 50% by volume silicon carbide fibers.

Abstract: A silicon carbide fiber reinforced barium modified magnesium aluminosilicate matrix composite is described having high strength and thermal stability at temperature in excess of 1200.degree. C. The matrix material contains about 5% to about 14% magnesium oxide and about 5% to about 25% barium oxide. While any suitable ratios of fiber to matrix can be used, the composite for most applications for example, in the heat engine area, will contain approximately 20% to 50% by volume silicon carbide fibers.

Abstract: A silicon carbide fiber reinforced glass-ceramic matrix composite is disclosed having high strength, fracture toughness, and improved oxidative stability even at high temperature use, e.g., in excess of 1000.degree. C. The composite is made up of a plurality of glass-ceramic layers, each layer reinforced with a plurality of unidirectional continuous length silicon carbide or discontinuous SiC fibers. The composite is formed by starting with the matrix material (preferably lithium aluminosilicate) in the glassy state and converting it from the glassy state to the crystalline state after densification of the composite. Ta or Nb compounds are added to the matrix composition prior to consolidation to form a reaction or diffusion barrier around the SiC fiber, resulting in composites with high temperature oxidation stability. Substitution of at least part of the Li.sub.2 O in the matrix with MgO results in an even higher temperature stable composite, e.g., up to about 1200.degree. C.

Abstract: The impact resistance of hot pressed silicon carbide articles is improved by providing thereon a layer of material resulting from the reaction of silicon in a dilute hydrocarbon gas atmosphere. To form the impact absorbing layer of porous silicon carbide, a silicon powder compact is heated at about 1400.degree. C. in a gas stream comprised predominantly of a carrier gas such as hydrogen, with a reactive hydrocarbon gas such as methane. Unitary articles may also be formed.

Abstract: A compliant tubular liner particularly adapted to withstand brisant forces is disclosed. These liners comprising graphite or silicon carbide fiber reinforced glass or glass-ceramic have a high fracture toughness, a relatively low elastic modulus and a high temperature resistance. These articles are particularly useful as gun barrel liners.

Abstract: The instant invention is directed to the preparation of glass-ceramic bodies exhibiting high strengths and use temperatures up to 1200.degree. C. The bodies consist essentially, expressed in terms of weight percent on the oxide basis, of______________________________________ Li.sub.2 O 1.5-5 Al.sub.2 O.sub.3 15-25 SiO.sub.2 60-75 ZrO.sub.2 1-5 Nb.sub.2 O.sub.5 0-10 Ta.sub.2 O.sub.5 0-10 Nb.sub.2 O.sub.5 + Ta.sub.2 O.sub.5 1-10 MgO 0-10 ______________________________________where excellent resistance to oxidation up to temperatures of 1200.degree. C. is desired, 0.5-3% As.sub.2 O.sub.3 will be included in the composition.

Abstract: Discontinuous silicon carbide fiber reinforced ceramic composites are disclosed having high strength, fracture toughness, and oxidative stability, even in high temperature oxidative environments. Disclosed composites include silicon carbide fiber reinforced aluminosilicate, lithium aluminosilicate, barium aluminosilicate, magnesium aluminosilicate, and combinations thereof. Flexural strengths in excess of 20,000 psi (138 MPa) at temperatures in excess of 1000.degree. C. are attainable with such composites. The composite is formed by starting with the ceramic matrix material in the glassy state and converting it from the glassy state to the ceramic state after densification of the composite.

Abstract: Discontinuous silicon carbide fiber reinforced glass composites are disclosed having high strength, fracture toughness, and oxidative stability, even in high temperature oxidative environments. Disclosed composites include silicon carbide fiber reinforced borosilicate glass, high silica content glass, and aluminosilicate glass. Flexural strengths in excess of 20,000 psi (138 MPa) at temperatures in excess of 500.degree. C. are attained with such composites.

Abstract: To prevent corrosion in subsequent high temperature exposure, backers for electron beam hole drilling of nickel base superalloys contain glass particulates of the borosilicate and aluminosilicate types, having an alkali metal oxide content of less than 1 weight percent and a heavy metal (Pb, Bi, Sn, Sb, As) content of less than 25 ppm. Preferably the binder is a soluble inorganic material, such as magnesium dichromate or a polymer, also free of alkali metal content.