Patents by Inventor John J. Chen

John J. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220372018
    Abstract: Amide compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
    Type: Application
    Filed: August 3, 2020
    Publication date: November 24, 2022
    Applicant: AMGEN INC.
    Inventors: Nuria A. TAMAYO, Abhisek BANERJEE, Jian Jeffrey CHEN, Matthew Richard KALLER, Thomas T. NGUYEN, Nobuko NISHIMURA, Qiufen May XUE, John Gordon ALLEN, Michael J. FROHN
  • Publication number: 20220340524
    Abstract: Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using positron emission tomography or fluorescence imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using radiolabeled arid unlabeled compounds are also provided.
    Type: Application
    Filed: April 29, 2022
    Publication date: October 27, 2022
    Inventors: John W. Chen, Cuihua Wang, Edmund J. Keliher
  • Publication number: 20220307434
    Abstract: A variety of methods and arrangements are described for operating an engine in a skip fire manner so that engine requirements, such as exhaust temperature, exhaust flow, torque and NVH, are met.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 29, 2022
    Applicants: Tula Technology, Inc., Cummins, Inc.
    Inventors: Louis J. Serrano, Kevin Shikui Chen, Xiaoping Cai, John Fuerst
  • Publication number: 20220259188
    Abstract: The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.
    Type: Application
    Filed: June 1, 2020
    Publication date: August 18, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Hua Zhou, John J. Acton, III, Michael J. Ardolino, Yi-Heng Chen, Peter H. Fuller, Anmol Gulati, Rebecca Elizabeth Johnson, William P. Kaplan, Solomon D. Kattar, Mitchell H. Keylor, Derun Li, Kaitlyn Marie Logan, Min Lu, Gregori J. Morriello, Santhosh F. Neelamkavil, Barbara Pio, Nunzio Sciammetta, Vladimir Simov, Jing Su, Luis Torres, Xin Yan
  • Publication number: 20220233827
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: April 12, 2022
    Publication date: July 28, 2022
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Publication number: 20220233238
    Abstract: Embodiments of the present invention provide a device and a method for at least one disease by delivering an effective amount of energy and/or formulation to tissue on or near to a body lumen wall. The formulation can include at least one of a gas, a vapor, a liquid, a solution, an emulsion, a suspension of one or more ingredients, or a combination thereof. The amounts of the formulation and/or energy delivered can be effective to injure or damage tissue, nerves, and/or nerve endings to relieve disease symptoms.
    Type: Application
    Filed: June 25, 2020
    Publication date: July 28, 2022
    Inventors: Lixiao Wang, John J. Chen, The Thomas Trinh Tran
  • Publication number: 20220236466
    Abstract: An optical film includes a plurality of alternating first and second polymeric layers, such that the first polymeric layers have a smaller average in-plane index of refraction than the second polymeric layers and the first polymeric layers have a glass transition temperature of at least 107 deg. C. The optical film may be a reflective polarizer. An optical stack includes a linear absorbing polarizer and the reflective polarizer disposed on, and bonded to, the absorbing polarizer. The reflective polarizer has an optical reflectance of at least 60% for a first polarization state and an optical transmittance of at least 60% for an orthogonal second polarization state. When heated at 105 deg. C. for 15 minutes, a difference in shrinkage of the reflective polarizer and the absorbing polarizer along the first and second polarization states is greater than about zero and 0.2%, respectively.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 28, 2022
    Inventors: Adam D. Haag, Yi-Chen Chen, Tze Yuan Wang, Hiroki Matsuda, Michelle L. Toy, Ryan J. Eismin, John F. VanDerlofske, III, David J. McDaniel, Matthew B. Johnson
  • Publication number: 20220210008
    Abstract: Data is received describing a local model of a first device generated by the first device based on sensor readings at the first device and a global model is updated that is hosted remote from the first device based on the local model and modeling devices in a plurality of different asset taxonomies. A particular operating state affecting one or more of a set of devices deployed in particular machine-to-machine network is detected and the particular machine-to-machine network is automatically reconfigured based on the global model.
    Type: Application
    Filed: August 6, 2021
    Publication date: June 30, 2022
    Applicant: Intel Corporation
    Inventors: Shao-Wen Yang, Michael J. Nolan, Ignacio J. Alvarez Martinez, Robert Adams, John Brady, Mark Kelly, Yen-Kuang Chen
  • Publication number: 20200398032
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 24, 2020
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Publication number: 20200360671
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: August 6, 2020
    Publication date: November 19, 2020
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Patent number: 10758713
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: September 1, 2020
    Assignee: Neurotronic, Inc.
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Publication number: 20200016379
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 16, 2020
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Publication number: 20200009355
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 9, 2020
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Publication number: 20190274687
    Abstract: Embodiments of the present invention provide a magnetic anastomosis device (MAD), a delivery catheter for the MAD, and a method for treating at least one of diabetes, obesity, digestive disease, and non-alcoholic fatty liver disease. In embodiments of the present invention, a pair of the MADs are delivered in body lumen by endoscopic and/or laparoscopic techniques. An anastomosis between two adjacent body lumens is formed by compression of the pair of MADs followed by necrosis and regeneration of the lumen tissue. The bodily fluids are then redirected through the formed anastomosis to relieve disease symptoms.
    Type: Application
    Filed: September 20, 2017
    Publication date: September 12, 2019
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang, Craig C. Belton, Shannon R. Stroud, Richard Cornelius, Scott Naisbitt
  • Patent number: 10363400
    Abstract: A tube-in-tube assembled parison for preparation of an elongated medical device. The parison if formed by assembling in tube-in-tube fashion a first tube of orientable polymer material and a second tube formed of orientable polymer material disposed around the first tube, with an adhesive tie layer disposed between the first and second tubes. The tubes are brought into contact to form a unitary parison. The adhesive may allow movement between the polymer layers during balloon blowing. The first tube, or the second tube, or both, may have been longitudinally pre-stretched after formation thereof but before assembly of the parison.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: July 30, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Nao Lee, Ying Xiong, Joe Khammoungkhoune, John J. Chen
  • Patent number: 10286191
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue, In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: May 14, 2019
    Assignee: Neurotronic, Inc.
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Patent number: 10286115
    Abstract: An expandable medical balloon including an inner layer formed of a poly (ether-block-amide) copolymer and an outer layer formed of a polyamide, the expandable medical balloon having a burst strength of greater than 50,000 psi, and to methods of making and using the same.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: May 14, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: John J. Chen, Daniel J. Horn
  • Publication number: 20190038881
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: October 10, 2018
    Publication date: February 7, 2019
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Publication number: 20180015264
    Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue, In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.
    Type: Application
    Filed: October 30, 2015
    Publication date: January 18, 2018
    Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
  • Patent number: 9675414
    Abstract: An expandable medical balloon for transmitting radiofrequency energy, the medical balloon comprising at least one polymeric electrically-insulating layer and at least one polymeric electrically-conductive layer, wherein at least portions of the polymeric electrically-insulating layer are moveable relative to the polymeric electrically-conductive in said at least one pressurizable expanded state.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: June 13, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Daniel J. Horn, Robert N. Squire, Adam Joseph Royer, Jeffrey S. Lindquist, John J. Chen