Abstract: A cleaner system for removing solid debris and contaminants from a feed slurry includes a cleaner operable to separate a feed slurry into an accepted slurry and a reject slurry, the reject slurry including the solid debris and contaminants. The cleaner system further includes a dilution device fluidly coupled to a reject outlet of the cleaner. The dilution device includes a dilution water hydrocyclone having a dilution water inlet, a cyclonic flow section, an underflow outlet at a downstream end of the cyclonic flow section, and a reject slurry inlet in a top of the dilution water hydrocyclone. The dilution water hydrocyclone further includes a flow director disposed between the dilution water inlet and the reject slurry inlet and operable to direct the flow of dilution water from the dilution water inlet in at least an axial direction towards the cyclonic flow section.

Abstract: Apparatus and methods are provided for controlling influent feed to produce a substantially uniform flow to a clarifier tank (2) to thereby enhance the settling efficiency within the clarifier. The apparatus comprises a feedwell (24) having a roof (26) and continuous sidewall (28) that together define a feedwell main body enclosure. Influent is fed via a relatively inboard tangential feed mechanism (108) to the inside of the roof (26) from an entry point proximate the center of the roof (150). Influent energy is properly distributed via the action of centrifugal force to generate a uniform axial flow within the feedwell main body which, in turn, is fed into the clarifier tank. Optional baffle members (152, 158) may be provided in the housing to slow angular momentum of the influent which, due to its original feed location, would necessarily be at a relatively low level.

Abstract: An improvement to a mechanical refining system relates to an apparatus including three or more actuators (100) coupled to a stator (42) of the refining system, and a controller for independently operating the actuators. An improved method of refining permits adjustment of the overall width of a refining gap between refining elements mounted by the stator and a rotor as well as the trim of the refining elements relative to each other.

Abstract: Apparatus and methods are provided for controlling influent feed to produce a substantially uniform flow to a clarifier tank (2) to thereby enhance the settling efficiency within the clarifier. The apparatus comprises a feedwell (24) having a roof (26) and continuous sidewall (28) that together define a feedwell main body enclosure. Influent is fed via a relatively inboard tangential feed mechanism (108) to the inside of the roof (26) from an entry point proximate the center of the roof (150). Influent energy is properly distributed via the action of centrifugal force to generate a uniform axial flow within the feedwell main body which, in turn, is fed into the clarifier tank. Optional baffle members (152, 158) may be provided in the housing to slow angular momentum of the influent which, due to its original feed location, would necessarily be at a relatively low level.

Abstract: Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation improving amount of a compound of the formula I:

Abstract: The present invention relates to methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: A paper pulp refiner with control system employs active hydrostatic bearings for supporting the refiner rotor, at least in part, the hydrostatic bearings are defined between the refiner rotor plates (25, 55) and stator plates (22, 60) through openings (40, 62, 85) formed in the stator plates for the admission of active hydrostatic fluid. The control fluid flows into the refiner gap under controlled volume and pressure, employing the refining plates as active hydrostatic bearings and flows into the process fluid. Hydrostatic control fluid is used, which is non-contaminated to the process fluid. The rotors of the paper pulp refiners may also be controlled by hydrostatic bearing surfaces formed between relative rotating and non-rotating components, such surfaces having passageways also opening into the process fluid. In the event of loss of control or function, the refiner may continue to operate on the hydrostatic bearings until the control function can be restored.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise substituted imidazolium compounds capable of inhibiting the formation of, as well as reversing already formed, advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: A paper pulp refiner with control system employs active hydrostatic bearings for supporting the refiner rotor, at least in part, the hydrostatic bearings are defined between the refiner rotor plates (25, 55) and stator plates (22, 60) through openings (40, 62, 85) formed in the stator plates for the admission of active hydrostatic fluid. The control fluid flows into the refiner gap under controlled volume and pressure, employing the refining plates as active hydrostatic bearings and flows into the process fluid. Hydrostatic control fluid is used, which is non-contaminated to the process fluid. The rotors of the paper pulp refiners may also be controlled by hydrostatic bearing surfaces formed between relative rotating and non-rotating components, such surfaces having passageways also opening into the process fluid. In the event of loss of control or function, the refiner may continue to operate on the hydrostatic bearings until the control function can be restored.

Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

Abstract: The invention pertains to equipment and methods in which the rotatable drive member of a variable speed motor, such as a switched reluctance motor, carries a rotatable pulp processing element (10). Magnetic bearings (22, 24) levitatingly support both the rotatable drive member (15) and associated rotatable pulp processing element (41) and control axial and radial positionning thereof relative to the axis of rotation of the drive member.

Abstract: Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: wherein the dotted line between carbons 5 and 6, the dotted line between carbon 4 and R2, and the dotted line between carbon 11 and R3 each independently represent an optional double bond from the respective numbered carbon to a linked carbon, and wherein X is hydroxy or, together with Y is oxy linking carbon 8 and carbon 12.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

Abstract: Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation improving amount of a compound of the formula I: 1

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.