Patents by Inventor John J. Farrar

John J. Farrar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the treatment or inhibition of ileus
    Patent number: 7696220
    Abstract: Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: April 13, 2010
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, Peter J. Schied, William K. Schmidt, Randall L. Carpenter
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 7294647
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: wherein X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: November 13, 2007
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6960612
    Abstract: Methods for prevention or treatment of pruritus are provided. The methods comprise administering to a patient an effective amount of a kappa opioid receptor agonist compound. The involved kappa opioid receptor agonist compounds are of the type represented by the following formula III wherein R1, R2, Ar, X7, and n are as defied in the specification.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: November 1, 2005
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Publication number: 20040220112
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and pruritic agents are provided.
    Type: Application
    Filed: June 5, 2003
    Publication date: November 4, 2004
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Publication number: 20030236248
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and pruritic agents are provided.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 25, 2003
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Novel methods for the treatment and prevention of ileus
    Publication number: 20020188005
    Abstract: Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaternary benzomorphans. The methods are particularly suitable for treating and/or preventing postsurgical ileus and postpartum ileus.
    Type: Application
    Filed: June 13, 2002
    Publication date: December 12, 2002
    Applicant: Adolor Corporation
    Inventors: John J. Farrar, Peter J. Schied, William K. Schmidt, Randall L. Carpenter
  • Methods for the treatment and prevention of ileus
    Patent number: 6469030
    Abstract: Methods for the treatment and/or prevention of ileus are disclosed. The methods comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: October 22, 2002
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, Peter J. Schied, William K. Schmidt, Randall L. Carpenter
  • Methods and compositions involving opioids and antagonists thereof
    Patent number: 6451806
    Abstract: Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: September 17, 2002
    Assignee: Adolor Corporation
    Inventor: John J. Farrar
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Publication number: 20020042399
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided.
    Type: Application
    Filed: January 26, 2001
    Publication date: April 11, 2002
    Applicant: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Peripherally acting anti-pruritic opiates
    Patent number: 6353004
    Abstract: Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R2, R3, R4, R7, Ar1 and Ar2 are as defined in the specification in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: March 5, 2002
    Assignee: Adolor Coporation
    Inventors: John J. Farrar, Alan Cowan
  • Novel methods and compositions involving opioids and antagonists thereof
    Publication number: 20010047005
    Abstract: Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea.
    Type: Application
    Filed: November 29, 2000
    Publication date: November 29, 2001
    Inventor: John J. Farrar
  • Novel methods for the treatment and prevention of ileus
    Publication number: 20010036951
    Abstract: Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaternary benzomorphans. The methods are particularly suitable for treating and/or preventing postsurgical ileus and postpartum ileus.
    Type: Application
    Filed: November 29, 2000
    Publication date: November 1, 2001
    Inventors: John J. Farrar, Peter J. Schied, William K. Schmidt, Randall L. Carpenter
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6180623
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and methods of using them as analgesics and anti-pruritic agents are provided. The compounds of formula IV have the structure: wherein X9; R1, R2, R3, R4; and n are as described in the specification.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: January 30, 2001
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
    Patent number: 6156769
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: December 5, 2000
    Assignee: Apolor Corp.
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
    Patent number: 6048860
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: April 11, 2000
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6028063
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compounds of formula III having the structure: ##STR1## wherein Ar and X.sup.7 ;R.sub.1 and R.sub.2 ; andn are as described in the specification.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: February 22, 2000
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist anti-pruritic pharmaceutical formulaitons and method of treating pruritus therewith
    Patent number: 6004964
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: December 21, 1999
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 5981513
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: ##STR1## wherein X.sub.4, X.sub.5 ;R.sub.1, R.sub.2 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: March 21, 1998
    Date of Patent: November 9, 1999
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5945443
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formulae IV having the structure: ##STR1## wherein X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ;and n are as described in the specification.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: August 31, 1999
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: RE38133
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, III and IV have the structure: wherein: X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: June 3, 2003
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang