Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided is a system configured to allocate healthcare resources for population health management using time values, health scores, or health condition labels stored in a population of records.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Automatic alignment of the zone axis of a sample and a charged particle beam is achieved based on a diffraction pattern of the sample. An area corresponding to the Laue circle is segmented using a trained network. The sample is aligned with the charged particle beam by tilting the sample with a zone axis tilt determined based on the segmented area.

Abstract: Automatic alignment of the zone axis of a sample and a charged particle beam is achieved based on a diffraction pattern of the sample. An area corresponding to the Laue circle is segmented using a trained network. The sample is aligned with the charged particle beam by tilting the sample with a zone axis tilt determined based on the segmented area.

Abstract: Automatic alignment of the zone axis of a sample and a charged particle beam is achieved based on a diffraction pattern of the sample. An area corresponding to the Laue circle is segmented using a trained network. The sample is aligned with the charged particle beam by tilting the sample with a zone axis tilt determined based on the segmented area.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Assays and reagents for the detection of autoantibodies to detect ovarian carcinomas are provided.

Abstract: A buffing and burnishing composition for cleaning, polishing and for reconditioning plastic and plastic coated floor surfaces, and other floor surfaces to which floor finishes including "self-polishing" preparations have been applied. The composition includes a water soluble, low volatility, linear polymer of ethylene and propylene oxide as a combination low-volatility, lubricant and plasticizer, a glycol ether as a cooperating solvent, cleaner and coupling and stabilizing agent, and a surfactant as a wetting agent and cleaner, and water. The composition is characterized by the absence of wax and ingredients which give rise to wax-like residues, by the capability of effectively solubilizing and removing any clouding wax and wax-like deposits present, by a reduced evaporation rate, and an enhanced stability in the presence of heat generated during floor surface buffing and polishing procedures.

Abstract: An improved surfactant system comprising a mixture of a non-ionic detergent, a tertiary amine oxide or amphoteric detergent, and a quaternary ammonium halide. The surfactant system of the invention is combined with other ingredients to yield 14 different commercially useful cleaners. Each of these cleaners has improved detergent properties compared with prior art cleaners.

Abstract: An improved surfactant system comprising a mixture of a non-ionic detergent, a tertiary amine oxide or amphoteric detergent, and a quaternary ammonium halide. The surfactant system of the invention is combined with other ingredients to yield 14 different commercially useful cleaners. Each of these cleaners has improved detergent properties compared with prior art cleaners.

Abstract: An improved surfactant system comprising a mixture of a non-ionic detergent, a tertiary amine oxide, and a quaternary ammonium halide. The surfactant system of the invention is combined with other ingredients to yield 14 different commercially useful cleaners. Each of these cleaners has improved detergent properties compared with prior art cleaners because of a high proportion of quaternary ammonium halide in the concentrated surfactant system used as a principal ingredient therein.

Abstract: An improved detergent mixture for cleaning hard surfaces comprising a mixture of a non-ionic detergent, a tertiary amine oxide, and a quaternary dimethyl ammonium halide. The mixture having a particular combination of ingredient concentrations described exhibits improved detergency compared with compositions containing only one or two of these ingredients at equivalent concentrations.