Patents by Inventor John J. G. Mullins

John J. G. Mullins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 2-acyl substituted chromanes and intermediates thereof
    Patent number: 6903227
    Abstract: Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: June 7, 2005
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: James Kanter, John J. G. Mullins, Anjali Pandey, Robert Scarborough
  • Methods for producing amino substituted chromanes and intermediates thereof
    Patent number: 6855833
    Abstract: Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: February 15, 2005
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: James Kanter, John J. G. Mullins, Robert Scarborough, Derek Walker, Thomas Hense
  • Methods for producing amino substituted chromanes and intermediates thereof
    Publication number: 20040225137
    Abstract: Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
    Type: Application
    Filed: August 25, 2003
    Publication date: November 11, 2004
    Inventors: James Kanter, John J.G. Mullins, Robert Scarborough, Derek Walker, Thomas Hense
  • Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor
    Patent number: 6756403
    Abstract: Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: June 29, 2004
    Assignee: Eli Lilly and Company
    Inventors: Barbara Briggs, James Kanter, John J. G. Mullins, Gerd Ruhter, Uko Udodong, Milton Zmijewski, Jr., Daniel Verral, II
  • Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor
    Publication number: 20040053992
    Abstract: Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.
    Type: Application
    Filed: July 11, 2003
    Publication date: March 18, 2004
    Inventors: Barbara Briggs, James Kanter, John J.G. Mullins, Gerd Ruhter, Uko Udodong, Milton Zmijewski Jr., Daniel Verral II
  • Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives
    Publication number: 20040044225
    Abstract: Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.
    Type: Application
    Filed: July 3, 2003
    Publication date: March 4, 2004
    Inventors: James Kanter, Charles Marlowe, Anjali Pandey, John J.G. Mullins, Robert Scarborough, Greg Butke, Barry Jacobson, Derek Walker
  • Synthesis of 2-Acyl substituted chromanes and intermediates thereof
    Publication number: 20030233002
    Abstract: Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.
    Type: Application
    Filed: May 6, 2003
    Publication date: December 18, 2003
    Inventors: James Kanter, John J.G. Mullins, Anjali Pandey, Robert Scarborough