Patents by Inventor John J.G. Tesmer

John J.G. Tesmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF GRK5 AND GRK5 SUBFAMILY MEMBERS AND USES THEREOF
    Publication number: 20230212120
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an indolinone structure which function as inhibitors of GRK5, and their use as therapeutics for the treatment of heart conditions and cancer.
    Type: Application
    Filed: May 27, 2021
    Publication date: July 6, 2023
    Inventors: John J.G. Tesmer, Rachel Rowlands, Andrew White
  • G protein-coupled receptor kinase inhibitors and methods for use of the same
    Patent number: 10329283
    Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 25, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott D. Larsen, John J. G. Tesmer, Helen Waldschmidt, Kristoff Homan, Michael William Wilson
  • G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
    Patent number: 10023564
    Abstract: Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: July 17, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott D. Larsen, Kristoff Homan, Helen Waldschmidt, John J. G. Tesmer
  • G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME
    Publication number: 20180186779
    Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.
    Type: Application
    Filed: June 27, 2016
    Publication date: July 5, 2018
    Inventors: Scott D. Larsen, John J.G. Tesmer, Helen Waldschmidt, Kristoff Homan, Michael William Wilson
  • G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME
    Publication number: 20170240538
    Abstract: Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
    Type: Application
    Filed: August 10, 2015
    Publication date: August 24, 2017
    Inventors: Scott D. Larsen, Kristoff Homan, Helen Waldschmidt, John J.G. Tesmer
  • Compositions and methods for altering cocaine esterase activity
    Patent number: 8501692
    Abstract: The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: August 6, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Roger K. Sunahara, John J. G. Tesmer, Diwahar Narasimhan, James H. Woods, Mark R. Nance, Elin Edwald
  • COMPOSITIONS AND METHODS FOR ALTERING COCAINE ESTERASE ACTIVITY
    Publication number: 20130039900
    Abstract: The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.
    Type: Application
    Filed: December 14, 2010
    Publication date: February 14, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Roger K. Sunahara, John J.G. Tesmer, Diwahar Narasimhan, James H. Woods, Mark R. Nance, Elin Edwald