Patents by Inventor John J. Grome

John J. Grome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of theophylline derivatives for the treatment and prophylaxis of states of shock, novel xanthine compounds and processes for their preparation
    Patent number: 6214992
    Abstract: Theophylline derivatives having at least one ether function in the structurally modified methyl radical in the 1-position that are useful in the treatment and prophylaxis of states of shock, new xanthine compounds having this substitution pattern, and processes for their preparation.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: April 10, 2001
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ulrich Gebert, Erhard Wolf, Elisabeth Defossa, Uwe Heinelt, Hiristo Anagnostopulos, Karl Rudolphi, John J. Grome
  • Xanthine compounds having terminally animated alkynol side chains
    Patent number: 5965555
    Abstract: Compounds of the formula I, ##STR1## in which one of the radicals R.sup.1 and R.sup.3 is an alkynol residue of the formula Ia or Ib ##STR2## are suitable for producing pharmaceuticals having a neuroprotective effect.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: October 12, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ulrich Gebert, Elisabeth Defossa, Uwe Heinelt, Karl Rudolphi, John J. Grome
  • Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation
    Patent number: 5922868
    Abstract: Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation.The invention relates to the use of xanthine derivatives of the formula I ##STR1## in which R.sup.2 is a (C.sub.1 -C.sub.4)-alkyl group and at least one of the symbols R.sup.1 and R.sup.3 is a radical of the formula II or III ##STR2## in which A is CHOH, CO or dioxolane, R.sup.4 is a hydrogen atom or a (C.sub.1 -C.sub.4)-alkyl group and n is 0 to 5, and in which R.sup.5 and R.sup.6 are hydrogen atoms or (C.sub.1 -C.sub.4)-alkyl groups or, together with the nitrogen atom to which they are bonded, form a 5- to 7-membered ring, it being possible for one carbon atom to be replaced by an oxygen or nitrogen atom, m is 1 or 2 and the other radical R.sup.1 or R.sup.3, if appropriate, is a hydrogen atom, a (C.sub.1 -C.sub.6)-alkyl group or a (C.sub.3 -C.sub.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: July 13, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Thorwart, Harald Furrer, Erhard Wolf, Ulrich Gebert, Erhard Rossmanith, John J. Grome, Ernst-Jurgen Schneider
  • Pyridopyrimidinediones, processes for their preparation and their use as drugs
    Patent number: 5556854
    Abstract: Pyridopyrimidinediones, processes for their preparation and their use as drugsA compound of the formula I: ##STR1## and/or physiologically acceptable salts of the compound of the formula I, and/or optionally stereoisomeric forms of the compound of the formula I, are suitable for the preparation of drugs for the treatment of circulatory disorders and/or neurodegenerative diseases.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: September 17, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Harald Furrer, Dirk Seiffge, Ismahan Okyayuz-Baklouti, John J. Grome
  • Xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas
    Patent number: 5409935
    Abstract: The use of xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas (CCT)The use of xanthine derivatives of the formula I ##STR1## and of their physiologically tolerable salts, in which R.sup.1 is oxoalkyl, hydroxyalkyl or alkyl, R.sup.2 is hydrogen or alkyl and R.sup.3 is hydrogen, alkyl, oxoalkyl or an alkyl having up to 6 carbon atoms, whose carbon chain is interrupted by an oxygen atom, for the production of pharmaceuticals for the treatment of disorders which can occur after cranio-cerebral traumas is described.
    Type: Grant
    Filed: July 9, 1992
    Date of Patent: April 25, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Peter Schubert, John J. Grome, Barbara Kittner, Karl Rudolphi, Ulrich Gebert