Patents by Inventor John J. Grzesiak

John J. Grzesiak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for modifying the binding activity of cell adhesion receptors
    Patent number: 5759855
    Abstract: The invention relates to the regultory role of cations on the dynamics of integrin-mediated cell adhesion and migration. In one aspect, methods of promoting or inhibiting the migration of integrin-expressing cells are provided by controlling the amount of cations, such as Mg.sup.2+ or Ca.sup.2+, in contact with the integrins of the cells. Methods of modifying the binding avidity of an integrin for its ligand are also provided by regulating the concentration of cations in contact with the integrin. The invention further relates to methods of using cations for a variety of applications and in particular for promoting wound healing.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: June 2, 1998
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Michael D. Pierschbacher, John J. Grzesiak, Daniel Kirchhofer
  • Growth of adult pancreatic islet cells
    Patent number: 5681587
    Abstract: A method of increasing the number of adult pancreatic islet cells available for transplantation by contacting the cells with laminin 5 extracellular matrix. When contacted with the deposited matrix produced by 804G rat bladder carcinoma cells, a 1,500 fold increase in cell number is observed after three passages in culture. Islet cell expansion also occurs when cells are contacted with 804G soluble matrix. The expanded islet cells contain insulin and respond to glucose challenge.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: October 28, 1997
    Assignee: Desmos, Inc.
    Inventors: Craig Halberstadt, Michael Zimber, John J. Grzesiak
  • Laminin 5 for growth of pancreatic islet cells
    Patent number: 5672361
    Abstract: A method of expanding the number of pancreatic islet cells for transplantation. Fetal islet cells are cultured in the presence of laminin 5 extracellular matrix, resulting in a significant increase in cell number after passaging in culture. The expanded islet cells contain insulin and respond to glucose challenge.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: September 30, 1997
    Assignee: Desmos, Inc.
    Inventors: Craig Halberstadt, John J. Grzesiak