Patents by Inventor John J. Kearns
John J. Kearns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020119170Abstract: Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.Type: ApplicationFiled: April 26, 2002Publication date: August 29, 2002Inventors: Andrew S. Janoff, Thomas D. Madden, Pieter R. Cullis, John J. Kearns, Anthony G. Durning, Lawrence Boni, Robert P. Lenk, Robert Klimchak, Joel Portnoff
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Patent number: 6406713Abstract: Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.Type: GrantFiled: April 28, 1995Date of Patent: June 18, 2002Assignee: The Liposome Company, Inc.Inventors: Andrew S. Janoff, Thomas D. Madden, Pieter R. Cullis, John J. Kearns, Anthony G. Durning
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Patent number: 5783210Abstract: A composition having equal to or greater than about 97 percent by weight phosphatidylcholine and about equal to or less than about 3 percent by weight to about 0.5% sphingomylin and equal to or less than about 0.5% lysophosphatidylcholine (undetectable by UV at 205 nm) has been found to result in liposomes having improved stability. Methods for preparing the composition are disclosed whereby the phospholipids are extracted and then purified using silica chromatography.Type: GrantFiled: May 24, 1995Date of Patent: July 21, 1998Assignee: The Liposome Company, Inc.Inventors: Paul A. Tremblay, Robert L. Suddith, John J. Kearns
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Patent number: 5616334Abstract: Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.Type: GrantFiled: April 28, 1995Date of Patent: April 1, 1997Assignee: The Liposome Company, Inc.Inventors: Andrew S. Janoff, Lawrence Boni, Thomas D. Madden, Pieter R. Cullis, Robert P. Lenk, John J. Kearns, Anthony G. Durning, Robert Klimchak, Joel Portnoff
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Patent number: 5429823Abstract: A composition having equal to or greater than about 97 percent by weight phosphatidylcholine and about equal to or less than about 3 percent by weight to about 0.5% sphingomylin and equal to or less than about 0.5% lysophosphatidylcholine (undetectable by UV at 205 nm) has been found to result in liposomes having improved stability. Methods for preparing the composition are disclosed whereby the phospholipids are extracted and then purified using silica chromatography.Type: GrantFiled: September 9, 1994Date of Patent: July 4, 1995Assignee: The Liposome Company, Inc.Inventors: Paul A. Tremblay, Robert L. Suddith, John J. Kearns
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Patent number: 5084215Abstract: A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolaine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and utilizing an acetonitrile, acetonitrile-hydrocarbon, or acetonitrile-fluorocarbon solvent, which exhibit differential solubility properties towards the individual phospholipids.Type: GrantFiled: October 20, 1988Date of Patent: January 28, 1992Assignee: The Liposome Company, Inc.Inventors: John J. Kearns, Paul A. Tremblay
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Patent number: 4814111Abstract: A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and utilizing an acetonitrile, acetonitrile-hydrocarbon, or acetonitrile-fluorocarbon solvent, which exhibit differential solubility properties towards the individual phospholipids.Type: GrantFiled: November 7, 1986Date of Patent: March 21, 1989Assignee: Air Products and Chemicals, Inc.Inventors: John J. Kearns, Paul A. Tremblay, Raymond J. Robey, Swaminathan Sunder
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Patent number: 4714571Abstract: A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and utilizing an acetonitrile, acetonitrile-hydrocarbon, or acetonitrile-fluorocarbon solvent, which exhibit differential solubility properties towards the individual phospholipids.Type: GrantFiled: February 6, 1985Date of Patent: December 22, 1987Assignee: The Liposome Company, Inc.Inventors: Paul A. Tremblay, John J. Kearns
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Patent number: 4610868Abstract: Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties of the lipid matrix carriers of the present invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and avoidance of vascular occlusion in vivo; and avoidance of sequestration of the bioactive agent in the liver and spleen.Type: GrantFiled: March 20, 1984Date of Patent: September 9, 1986Assignee: The Liposome Company, Inc.Inventors: Michael W. Fountain, Steven J. Weiss, John J. Kearns, Alan L. Weiner, Mircea C. Popescu