Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A method of analyzing the operation of a delivery system. The method includes: determining a seeding plan; placing a seed piece into the delivery system; tracking the seed piece through the delivery system to generate tracking data; storing the tracking data in a central repository; and analyzing the tracking data to determine one or more faults.

Abstract: A method of analyzing the operation of a delivery system. The method includes: determining a seeding plan; placing a seed piece into the delivery system; tracking the seed piece through the delivery system to generate tracking data; storing the tracking data in a central repository; and analyzing the tracking data to determine one or more faults.

Abstract: A method of analyzing the operation of a delivery system. The method includes: determining a seeding plan; placing a seed piece into the delivery system; tracking the seed piece through the delivery system to generate tracking data; storing the tracking data in a central repository; and analyzing the tracking data to determine one or more faults.

Abstract: A blood component collection system is disclosed with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameters. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

Abstract: A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

Abstract: A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

Abstract: A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

Abstract: Disclosed is a system for determining whether semiconductor components are present and properly connected to a printed circuit board. The semi-conductor material between two pins of an integrated circuit forms a lateral NPN transistor, having its base connected directly to the substrate connection pin of the component. A constant voltage source is applied to the lateral transistor collector pin of the component being tested, and allowed to stabilize. A current or voltage source is then connected to the emitter pin of the lateral transistor, typically an adjacent pin, and a current or voltage pulse is applied to this pin. The current on the collector pin is then monitored and if a corresponding current pulse is detected, the emitter and collector pins, as well as the substrate connection pin of the component, are properly connected to the printed circuit board.