Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: The present invention provides a low-cost, low-power therapeutic hypothermia device for use in developing nations. The device includes a first and second receptacle separated by a space filled with a porous material such as sand. A cooling chemical can also be added to the porous material in order to speed cooling. Water is added to the porous material and a neonate is placed into the device for therapeutic hypothermia treatment. The neonate is monitored carefully using temperature sensors and a feedback system integrated into the device. Cooling can be modulated and/or warming commenced by adding Styrofoam blocks to raise the neonate off the surface of the device.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Provided are methods for the treatment of rheumatoid arthritis using compounds of formula Ia and Ib: or a pharmaceutically acceptable salt, hydrate or N-oxide thereof.

Abstract: Interconnection router arrangements are implemented using a variety of arrangements and methods. Using one such arrangement, an interconnection network router arrangement sends data units between a set of router inputs and a set of router outputs. The interconnection network router arrangement includes a sub-switch that is capable of selectively transferring a data unit from an array of sub-switch inputs to an array of sub-switch outputs. The sub-switch has a memory circuit for storing the data unit before the data unit is transferred to a sub-switch output and a memory circuit for storing the data unit after the data unit is transferred from the sub-switch inputs and before the data unit is sent to a router output.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Methods are provided for the synthesis of 1-[4-(substituted phenyl)-piperazin-1-yl ] -2- [3-(1H-imidazol-2-yl)-pyrazolo [3,4-b]pyridin-1-yl]-ethanone compounds via construction of the imidazole portion onto the corresponding aldehyde or nitrile compounds.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.

Abstract: A first-in, first-out (FIFO) memory system (10) includes first and second FIFOs (A and B). First and second multiplexers (12, 14) each have two input terminals for receiving data. An output terminal of the first multiplexer (12) is coupled to the first FIFO (A) and an output terminal of the second multiplexer (14) is coupled to the second FIFO (B). In response to the data being one data type, write control logic (90, 95, 100) is used to cause the data to be alternately written to the first and second FIFOs (A, B). In response to the data being a second data type, write control logic (90, 95, 100) is used to cause the data to be simultaneously written to the first and second FIFOs (A, B).

Abstract: In one aspect, the present invention is a technique of, and a system for conditioning power for a consuming device. In this regard, a power conditioning module, affixed to an integrated circuit device, conditions power to be applied to the integrated circuit device. The power conditioning module includes a semiconductor substrate having a first interface and a second interface wherein the first interface opposes the second interface. The power conditioning module further includes a plurality of interface vias, to provide electrical connection between the first interface and the second interface, and a first set of pads, disposed on the first interface and a second set of pads disposed on the second interface. Each of the pads is connected to a corresponding one of the interface vias on either the first or second interface. The power conditioning module also includes electrical circuitry, disposed within semiconductor substrate, to condition the power to be applied to the integrated circuit device.

Abstract: In one aspect, the present invention is a technique of, and a system for conditioning power for a consuming device. In this regard, a power conditioning module, affixed to an integrated circuit device, conditions power to be applied to the integrated circuit device. The power conditioning module includes a semiconductor substrate having a first interface and a second interface wherein the first interface opposes the second interface. The power conditioning module further includes a plurality of interface vias, to provide electrical connection between the first interface and the second interface, and a first set of pads, disposed on the first interface and a second set of pads disposed on the second interface. Each of the pads is connected to a corresponding one of the interface vias on either the first or second interface. The power conditioning module also includes electrical circuitry, disposed within semiconductor substrate, to condition the power to be applied to the integrated circuit device.

Abstract: A system and method for providing an air curtain for impeding the entry of dust, dirt, debris, smoke, insects and other airborne particulate matter into an interior area of an aircraft without the need for disposing heavy, bulky and high power consuming blower assemblies above the opening in the aircraft. The invention comprises a pair of air intake ducts each having a fan disposed therein. The fans draw an ambient airflow into the air intake ducts. Pressurized air from a power unit associated with the aircraft, such as an engine or auxiliary power unit, is injected into the air intake ducts. This has the effect of significantly accelerating the airflow in the air intake ducts to a velocity suitable for forming an air curtain. The air intake ducts are coupled to a manifold having a length sufficient to substantially span the opening of an aircraft at which the air curtain is formed.

Abstract: The present invention relates to the delivery of benzodiazepines through an inhalation route. Specifically, it relates to aerosols containing benzodiazepines that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a benzodiazepine. In a method aspect of the present invention, a benzodiazepine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a benzodiazepine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal.

Abstract: A first-in, first-out (FIFO) memory system (10) includes first and second FIFOs (A and B). First and second multiplexers (12, 14) each have two input terminals for receiving data. An output terminal of the first multiplexer (12) is coupled to the first FIFO (A) and an output terminal of the second multiplexer (14) is coupled to the second FIFO (B). In response to the data being one data type, write control logic (90, 95, 100) is used to cause the data to be alternately written to the first and second FIFOs (A, B). In response to the data being a second data type, write control logic (90, 95, 100) is used to cause the data to be simultaneously written to the first and second FIFOs (A, B).