Patents by Inventor John J. Lafferty

John J. Lafferty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .alpha.-adrenergic receptor antagonists and methods of use thereas
    Patent number: 5006521
    Abstract: Alpha-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonists to produce .alpha.-adrenoceptor antagonism in mammals.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: April 9, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: John J. Lafferty, Robert M. DeMarinis, Dinubhai H. Shah
  • .alpha.-adrenergic receptor antagonists
    Patent number: 4978660
    Abstract: .alpha.-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonists to produce .alpha.-adrenoceptor antagonism in mannals.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: December 18, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: John J. Lafferty, Robert M. DeMarinis, Joseph W. Venslavsky
  • Alpha-andrenergic receptor antagonists and use thereas
    Patent number: 4963547
    Abstract: Alpha-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonists to produce .alpha.-adrenoceptor antagonism in mammals.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: October 16, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: John J. Lafferty, Robert M. Demarinis, Dinubhai H. Shah
  • .alpha.-adrenergic receptor antagonists
    Patent number: 4959360
    Abstract: .alpha.-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonist to produce .alpha.-adrenoceptor antagonism in mammals.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: September 25, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: John J. Lafferty, Robert M. Demarinis, Joseph W. Venslavsky
  • N-Substituted pyrrolidineacetic acids and their esters
    Patent number: 4514414
    Abstract: N-Substituted pyrrolidineacetic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an esters of an N-unsubstituted pyrrolidineacetic acid followed by hydrolysis of the ester.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: April 30, 1985
    Assignee: Smithkline Beckman Corporation
    Inventors: William E. Bondinell, John J. Lafferty, Charles L. Zirkle
  • Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
    Patent number: 4383999
    Abstract: N-Substituted azaheterocyclic carboxylic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an ester of an N-unsubstituted azaheterocyclic carboxylic acid followed by hydrolysis of the ester.
    Type: Grant
    Filed: April 28, 1982
    Date of Patent: May 17, 1983
    Assignee: Smithkline Beckman Corporation
    Inventors: William E. Bondinell, John J. Lafferty, Charles L. Zirkle
  • Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
    Patent number: 4073912
    Abstract: Novel piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins administered internally to an animal host, in therapeutically effective amounts, produce antipsychotic activity essentially free of extrapyramidal symptoms.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: February 14, 1978
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, John J. Lafferty
  • Novel N-allyl and N-propargyl benzmorphan derivatives
    Patent number: 4048178
    Abstract: N-Allyl-benzmorphan compounds having structures distinguished by having either a 4,5 or 6 carbon containing allyl group at the 2- or N-position or various ether derivatives of the 2'-hydroxy group. The compounds are prepared by alkylation of appropriate N-nor bases and have analgetic antagonist activity particularly pronounced in countering the effects of overdosing. Certain N-acyl-2'-hydroxy-5,9-dimethyl-6,7-benzmorphan intermediates are also disclosed.
    Type: Grant
    Filed: March 10, 1960
    Date of Patent: September 13, 1977
    Assignee: Smith Kline & French Laboratories
    Inventors: Maxwell Gordon, John J. Lafferty
  • Novel compounds and compositions for treating Parkinson's disease
    Patent number: 3988457
    Abstract: .beta.-Naphthylmethyl piperazinyl derivates having anti-Parkinsonism activity prepared by condensation of .beta.-chloromethylnaphthalene with the appropriate substituted piperazine.
    Type: Grant
    Filed: July 17, 1975
    Date of Patent: October 26, 1976
    Assignee: SmithKline Corporation
    Inventors: Harlan F. Hill, John J. Lafferty
  • 3-Aminoindazole derivatives
    Patent number: RE28939
    Abstract: .Iadd.Pharmaceutical compositions having muscle relaxant and analgesic activity containing 3-aminoindazoles..Iaddend.
    Type: Grant
    Filed: September 28, 1972
    Date of Patent: August 24, 1976
    Assignee: SmithKline Corporation
    Inventors: John J. Lafferty, David H. Tedeschi, Charles L. Zirkle