Patents by Inventor John J. Langone

John J. Langone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Products and methods for treatment of cancer
    Patent number: 4699783
    Abstract: Disclosed are compositions for the treatment of cancer, such as lymphomas and solid tumors, methods of producing these compositions, and methods and regimens in using these compositions in the treatment of hosts having cancer.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: October 13, 1987
    Inventors: David S. Terman, Joseph P. Balint, John J. Langone
  • Immunoassay utilizing .sup.125 I Protein A
    Patent number: 4430318
    Abstract: An improved method for the preparation of .sup.125 I-labelled Protein A (.sup.125 I PA) of high specific and functional activity. .sup.125 I PA has been used in combination with purified rabbit IgG (immunoglobulin G) bound to a solid support to develop a competitive binding assay capable of detecting Protein A or human, rabbit and guinea pig IgG at the nanogram level. Additionally, .sup.125 I PA may be used to detect methotrexate, leucovorin and similar substances..sup.125 I PA has also been used to detect IgG anti-Forssman antibody bound to sheep erythrocytes and to line-1 and line-10 tumor cells and as an indirect assay for tumor associated antigen in the ascitic fluid of tumor-bearing guinea pigs.Additionally, an improved method of preparation of iodination of Protein A is utilized. This procedure used the Bolton-Hunter (1973) reagent of radioactive iodine in benzene which carrier is evaporated.
    Type: Grant
    Filed: October 1, 1981
    Date of Patent: February 7, 1984
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: John J. Langone