Abstract: A sock knit throughout of at least one body yarn including an integrally knit leg portion and a foot portion. Additional yarn is knit in plated relationship with the body yarn in the ball portion of the foot, providing a thickened fabric area. This thickened fabric area is anatomically shaped to fit the ball of one of either a right or a left foot. The invention may also include additional thickened fabric areas at the heel, arch and toe portions of the sock, which are also anatomically shaped to fit the foot. A method is also provided for minimizing foot discomfort by selecting from among a plurality of socks, each pair of socks having thickened fabric areas of different volume or thickness, the sock with a volume that matches the width of the wearer's foot.