Patents by Inventor John J. M. Wiener

John J. M. Wiener has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAGL INHIBITORS
    Publication number: 20240018120
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 18, 2024
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20230357190
    Abstract: Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: Thomas VETTER, John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20230265095
    Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)b enzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 1, 2022
    Publication date: August 24, 2023
    Inventors: Thomas VETTER, Martin JUHL, HEIDI LOPEZ DE DIEGO, Cheryl A. GRICE, John J.M. WIENER, Daniel J. BUZARD, Amy ALLAN, Susana DEL RIO GANCEDO, Samuel George ANDREW, Antonio CINCOTTI, Adam Ross PATTERSON, Richard James EDWARDS
  • PYRAZOLE MAGL INHIBITORS
    Publication number: 20230219897
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: March 16, 2023
    Publication date: July 13, 2023
    Inventors: Cheryl A. GRICE, John J.M. WIENER, Olivia D. WEBER, Katharine K. DUNCAN
  • Pyrazole MAGL inhibitors
    Patent number: 11655217
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising the same. The compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 23, 2023
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE
    Publication number: 20230097422
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Application
    Filed: March 25, 2022
    Publication date: March 30, 2023
    Inventors: Nidhi ARORA, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J.M. Wiener
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
    Publication number: 20230013755
    Abstract: The present disclosure is directed to the use of a compound of Formula (III) in the treatment of malignancies.
    Type: Application
    Filed: June 2, 2022
    Publication date: January 19, 2023
    Inventors: Sriram BALASUBRAMANIAN, Ivo CORNELISSEN, Yue GUO, Jocelyn H. LEU, Kathryn E. PACKMAN, James Alexander PALMER, Ulrike PHILIPPAR, Navin RAO, Mark S. TICHENOR, Jennifer D. VENABLE, John J. M. WIENER, Xin MIAO
  • MAGL inhibitors
    Patent number: 11434222
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: September 6, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: John J. M. Wiener, Cheryl A. Grice, Daniel J. Buzard, Justin S. Cisar, Olivia Delene Weber, Amy Allan, Nicholas Raffaele, Jeanne Moody, Michael B. Shaghafi
  • MAGL INHIBITORS
    Publication number: 20220153721
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 11, 2021
    Publication date: May 19, 2022
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne MOODY, Michael B. SHAGHAFI
  • Inhibitors of Bruton's tyrosine kinase and methods of their use
    Patent number: 11319329
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: May 3, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener
  • METHODS OF TREATING DISEASE WITH MAGL INHIBITORS
    Publication number: 20220031676
    Abstract: Provided herein are methods for the treatment of disease with monoacylglycerol lipase (MAGL) inhibitors.
    Type: Application
    Filed: November 26, 2019
    Publication date: February 3, 2022
    Inventors: Channing Rodney BEALS, Dallas JONES, Jason Robert CLAPPER, Gary Paul O'NEILL, Iain Peter FRASER, Jacqueline Lorayne BLANKMAN, John J.M. WIENER, Cheryl A. GRICE
  • DUAL MAGL AND FAAH INHIBITORS
    Publication number: 20210386734
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 16, 2021
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J.M. Wiener, Olivia D. Weber
  • Pyrazole MAGL inhibitors
    Patent number: 11149037
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 19, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi, John J. M. Wiener, Justin S. Cisar, Katharine K. Duncan
  • Dual MAGL and FAAH inhibitors
    Patent number: 11129827
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 28, 2021
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
    Publication number: 20210101910
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Application
    Filed: May 13, 2020
    Publication date: April 8, 2021
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J.M. Wiener
  • Inhibitors of Bruton's tyrosine kinase and method of their use
    Patent number: 10934310
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: March 2, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Kun Xiao, Feihuang Zhang, Yaoping Zhu
  • PYRAZOLE MAGL INHIBITORS
    Publication number: 20210053960
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 22, 2018
    Publication date: February 25, 2021
    Inventors: Cheryl A. GRICE, John J.M. WIENER, Olivia D. WEBER, Katharine K. DUNCAN
  • Pyrazole MAGL inhibitors
    Patent number: 10927105
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: February 23, 2021
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
  • Inhibitors of Bruton's tyrosine kinase and methods of their use
    Patent number: 10822348
    Abstract: The present disclosure is directed to compounds of formula I? and methods of their use and preparation, as well as compositions comprising compounds of formula I?.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: November 3, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Baoyu Hao, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Yaoping Zhu, Feihuang Zhang, Zheng Zhang, Kun Xiao
  • Inhibitors of Bruton's tyrosine kinase and method of their use
    Patent number: 10800792
    Abstract: The present disclosure is directed to compounds of formula I? and methods of their use and preparation, as well as compositions comprising compounds of formula I?.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: October 13, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Baoyu Hao, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Yaoping Zhu, Feihuang Zhang, Zheng Zhang, Kun Xiao