Patents by Inventor John J. McGuire

John J. McGuire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
    Patent number: 7687473
    Abstract: The present invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR). The method comprises the steps of administration of 5-amino-4-imidazolecarboxamide riboside (Z) or its base with the antifolate such that the targeted cells are exposed to both the antifolate and Z simultaneously. This results in increased influx of the antifolate. For MTX, accumulation of the more biologically active polyglutamate forms is also potentiated. This potentiation appears to be mediated by an effect on the RFC.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: March 30, 2010
    Assignee: Health Research, Inc.
    Inventor: John J. McGuire
  • Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
    Patent number: 5286726
    Abstract: This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: February 15, 1994
    Assignees: The Regents of the University of Michigan, Health Research, Inc., Merrell Dow Pharmaceuticals Inc.
    Inventors: Philippe Bey, James K. Coward, John J. McGuire
  • Method and system for propagating of plants
    Patent number: 4231188
    Abstract: A plant growing system is provided wherein a layer of sand is placed between two water-impermeable layers. The top impermeable layer covers the entire sand surface and is formed of a thin opaque plastic. Each container for a plant has prongs extending from the bottom which, when positioned on the top sheet, extends into the sand layer without contacting the bottom water-impermeable layer. Water and nutrients are metered into the sand layer which is transmitted into the containers by capillary action.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: November 4, 1980
    Inventors: John J. McGuire, Edward J. Auger