Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases.

Abstract: Exemplary compact multi-chamber diaphragm pumps and dispensers for dispensing foam soap or sanitizer are disclosed herein. An exemplary pump for pumping soap or sanitizer and air separately to be mixed remote from the pump and dispensed as a foam includes a liquid pump diaphragm and a dual flapper valve, wherein a first of the dual flapper valves is a liquid inlet valve and a second of the dual flapper valves is a liquid outlet valve. The pump further includes two or more air pump diaphragms and a valve plate. The valve plate has a liquid inlet passage, a liquid outlet passage, a liquid outlet valve seat, two or more air inlet passages, two or more air inlet valve anchors and two or more air inlet valves secured to the valve plate. A pump manifold is also included, the pump manifold includes a liquid inlet valve seat.

Abstract: Exemplary sanitary soap refilling systems and methods are disclosed herein. An exemplary refill refilling system includes a housing, a pump located within the housing, and a bulk storage tank connector. The bulk storage tank connector having a liquid outlet and an air inlet. A liquid inlet conduit is in fluid communication with the pump the liquid outlet. A refill connector is included. The refill connector has a liquid inlet and an air outlet. The refill connector air outlet and the bulk storage tank connector air inlet are in fluid communication with one another. The refill liquid inlet is in fluid communication with the pump.

Abstract: Exemplary power systems for dynamically controlling a dispenser drive motor for dispensing soap, sanitizing or lotion. An exemplary soap, sanitizing or lotion dispenser includes a housing, a receptacle for receiving a container for holding a soap, sanitizing or lotion, a container of soap, sanitizing or lotion and a pump secured to the container. The exemplary soap, sanitizing or lotion dispenser includes a power source, a motor and an actuator that couples the motor to the pump. In addition, the exemplary soap, sanitizing or lotion dispenser includes pulse width modulation circuitry in circuit communication with the power source and the motor. Movement of the actuator one actuation cycle dispenses a dose of soap, sanitizing or lotion. The pulse width modulation circuitry provides a plurality of voltage pulses to the motor to move the actuator one actuation cycle.

Abstract: Exemplary sanitary soap refilling systems and methods are disclosed herein. An exemplary refill refilling system includes a housing, a pump located within the housing, and a bulk storage tank connector. The bulk storage tank connector having a liquid outlet and an air inlet. A liquid inlet conduit is in fluid communication with the pump the liquid outlet. A refill connector is included. The refill connector has a liquid inlet and an air outlet. The refill connector air outlet and the bulk storage tank connector air inlet are in fluid communication with one another. The refill liquid inlet is in fluid communication with the pump.

Abstract: A dispenser includes a housing, an inverted container disposed in the housing, a outlet nozzle, a pump, a first check valve, and a second check valve. The pump is disposed between the container and the outlet nozzle. The pump includes a pump inlet a pump outlet, and a pump chamber. The pump chamber is movable between an expanded position and a compressed position. The first check valve is disposed between the pump and the outlet nozzle, and the first check valve has a first cracking pressure. The second check valve is disposed between the first check valve and the outlet nozzle, and the second check valve has a second cracking pressure. The second cracking pressure of the second check valve is greater than the first cracking pressure of the first check valve.

Abstract: Exemplary soap, sanitizer and lotion dispensers are disclosed herein. An exemplary dispenser includes a housing; a receptacle for receiving a container; a container of fluid comprising soap, sanitizer or lotion; a pump in fluid communication with the container; a power source; a pump coupled to a motor and pulse width modulation circuitry in circuit communication with the power source and the motor. The pulse width modulation circuitry is initially set to cause a selected dose of fluid to be dispensed at a base speed. A sensor for detecting a parameter indicative of an actual speed of a dispense of the fluid is also included. When the actual speed of the dispense of fluid is less than the base speed or greater than the base speed, the pulse width modulation circuitry adjusts the pulse width to cause the speed of a following dispense of fluid to be closer to the base speed.

Abstract: A foam dispenser includes a housing, a drive motor, and a foam pump. The foam pump includes a pump housing, and a molded multi-chamber diaphragm. The molded multi-chamber diaphragm includes a liquid pump diaphragm having a liquid pump stem and two or more air pump chambers each having an air pump stem. The length of the liquid pump stem is longer than the air pump stem. The foam pump further includes one or more outlet valves, a mixing chamber, an outlet for dispensing foam wherein the outlet is in fluid communication with the foam cartridge; and an actuator for sequentially actuating the liquid pump chamber and the two or more air pump chambers, wherein there is lost motion between the actuator and the liquid pump diaphragm.

Abstract: Exemplary table-top sanitizer dispensers and dip tube separation members are disclosed herein. An exemplary table-top sanitizer dispenser includes a container. The container has a neck that has an inside diameter. The container having an annular wall extending outward from the base of the neck. The table-top dispenser has pump that has a pump housing. The pump housing has an annular retention member at the bottom of the housing. A nozzle is secured to the pump housing. A closure is also secured to the pump housing. The table-top dispenser further includes a dip tube. The dip tube is secured to the annular retention member. A dip tube separation member extending outward from the dip tub is also included. The dip tube separation member has a biased state and an unbiased state. In the biased state the dip tube separation member has a diameter that is smaller than the inside diameter of the neck.

Abstract: An dispenser includes a housing, a container disposed in the housing for holding a liquid, a nozzle, and a pump. The pump is disposed between the container and the nozzle. The pump includes a pump inlet, a pump outlet, a pump chamber, a first check valve, and a second check valve. The pump inlet is in fluid communication with the container and the pump chamber, and the pump outlet is in fluid communication with the pump chamber and the nozzle. The pump chamber is movable between an expanded position and a compressed position. The first check valve is disposed between the container and the pump, and the first check valve has a first cracking pressure. The second check valve is disposed between the first check valve and the pump, and the second check valve has a second cracking pressure. The first cracking pressure of the first check valve is greater than the second cracking pressure of the second check valve.

Abstract: Exemplary power systems for dynamically controlling a dispenser drive motor for dispensing soap, sanitizing or lotion. An exemplary soap, sanitizing or lotion dispenser includes a housing, a receptacle for receiving a container for holding a soap, sanitizing or lotion, a container of soap, sanitizing or lotion and a pump secured to the container. The exemplary soap, sanitizing or lotion dispenser includes a power source, a motor and an actuator that couples the motor to the pump. In addition, the exemplary soap, sanitizing or lotion dispenser includes pulse width modulation circuitry in circuit communication with the power source and the motor. Movement of the actuator one actuation cycle dispenses a dose of soap, sanitizing or lotion. The pulse width modulation circuitry provides a plurality of voltage pulses to the motor to move the actuator one actuation cycle.

Abstract: A foam dispenser includes a housing, a drive motor, and a foam pump. The foam pump includes a pump housing, and a molded multi-chamber diaphragm. The molded multi-chamber diaphragm includes a liquid pump diaphragm having a liquid pump stem and two or more air pump chambers each having an air pump stem. The length of the liquid pump stem is longer than the air pump stem. The foam pump further includes one or more outlet valves, a mixing chamber, an outlet for dispensing foam wherein the outlet is in fluid communication with the foam cartridge; and an actuator for sequentially actuating the liquid pump chamber and the two or more air pump chambers, wherein there is lost motion between the actuator and the liquid pump diaphragm.

Abstract: Exemplary power systems for dynamically controlling a dispenser drive motor for dispensing soap, sanitizing or lotion. An exemplary soap, sanitizing or lotion dispenser includes a housing, a receptacle for receiving a container for holding a soap, sanitizing or lotion, a container of soap, sanitizing or lotion and a pump secured to the container. The exemplary soap, sanitizing or lotion dispenser includes a power source, a motor and an actuator that couples the motor to the pump. In addition, the exemplary soap, sanitizing or lotion dispenser includes pulse width modulation circuitry in circuit communication with the power source and the motor. Movement of the actuator one actuation cycle dispenses a dose of soap, sanitizing or lotion. The pulse width modulation circuitry provides a plurality of voltage pulses to the motor to move the actuator one actuation cycle.

Abstract: Exemplary embodiments of self-adjusting sanitizer/disinfectant sprayers are disclosed herein. An exemplary self-adjusting sanitizer/disinfectant sprayer includes a tank for holding sanitizer or disinfectant, one or more batteries, a motor, a motor controller, and a pump. The pump includes a pump inlet in fluid communication with an interior of the tank and a pump outlet. A processor, a dispensing wand and a flow sensor are also included. The flow sensor and motor controller are in circuit communication with the processor. The processor provides input to the motor controller for controlling the speed of the motor that drives the pump as a function of a signal indicative of the flow rate received from the flow sensor.

Abstract: Exemplary soap, sanitizer and lotion dispensers are disclosed herein. An exemplary dispenser includes a housing; a receptacle for receiving a container; a container of fluid comprising soap, sanitizer or lotion; a pump in fluid communication with the container; a power source; a pump coupled to a motor and pulse width modulation circuitry in circuit communication with the power source and the motor. The pulse width modulation circuitry is initially set to cause a selected dose of fluid to be dispensed at a base speed. A sensor for detecting a parameter indicative of an actual speed of a dispense of the fluid is also included. When the actual speed of the dispense of fluid is less than the base speed or greater than the base speed, the pulse width modulation circuitry adjusts the pulse width to cause the speed of a following dispense of fluid to be closer to the base speed.

Abstract: Exemplary soap, sanitizer and lotion dispensers are disclosed herein. An exemplary dispenser includes a housing; a receptacle for receiving a container; a container of fluid comprising soap, sanitizer or lotion; a pump in fluid communication with the container; a power source; a pump coupled to a motor and pulse width modulation circuitry in circuit communication with the power source and the motor. The pulse width modulation circuitry is initially set to cause a selected dose of fluid to be dispensed at a base speed. A sensor for detecting a parameter indicative of an actual speed of a dispense of the fluid is also included. When the actual speed of the dispense of fluid is less than the base speed or greater than the base speed, the pulse width modulation circuitry adjusts the pulse width to cause the speed of a following dispense of fluid to be closer to the base speed.

Abstract: An dispenser includes a housing, a container disposed in the housing for holding a liquid, a nozzle, and a pump. The pump is disposed between the container and the nozzle. The pump includes a pump inlet, a pump outlet, a pump chamber, a first check valve, and a second check valve. The pump inlet is in fluid communication with the container and the pump chamber, and the pump outlet is in fluid communication with the pump chamber and the nozzle. The pump chamber is movable between an expanded position and a compressed position. The first check valve is disposed between the container and the pump, and the first check valve has a first cracking pressure. The second check valve is disposed between the first check valve and the pump, and the second check valve has a second cracking pressure. The first cracking pressure of the first check valve is greater than the second cracking pressure of the second check valve.

Abstract: Exemplary sanitary soap refilling systems and methods are disclosed herein. An exemplary refill refilling system includes a housing, a pump located within the housing, and a bulk storage tank connector. The bulk storage tank connector having a liquid outlet and an air inlet. A liquid inlet conduit is in fluid communication with the pump the liquid outlet. A refill connector is included. The refill connector has a liquid inlet and an air outlet. The refill connector air outlet and the bulk storage tank connector air inlet are in fluid communication with one another. The refill liquid inlet is in fluid communication with the pump.

Abstract: A dispenser having a housing, a container disposed in the housing for holding a liquid, a nozzle, and a pump. The pump includes a pump inlet, a pump outlet, a pump chamber. The pump inlet is in fluid communication with the container and the pump chamber, and the pump outlet is in fluid communication with the pump chamber and the nozzle. The pump chamber is movable between an expanded position and a compressed position. A first check valve is disposed between the container and the pump, and the first check valve has a first cracking pressure. A second check valve is disposed between the first check valve and the pump, and the second check valve has a second cracking pressure. The first cracking pressure of the first check valve is greater than the second cracking pressure of the second check valve.

Abstract: Exemplary sanitary soap refilling systems and methods are disclosed herein. An exemplary refill refilling system includes a housing, a pump located within the housing, and a bulk storage tank connector. The bulk storage tank connector having a liquid outlet and an air inlet. A liquid inlet conduit is in fluid communication with the pump the liquid outlet. A refill connector is included. The refill connector has a liquid inlet and an air outlet. The refill connector air outlet and the bulk storage tank connector air inlet are in fluid communication with one another. The refill liquid inlet is in fluid communication with the pump.