Abstract: A system and method for identifying events occurring in a patient room during an interaction with a caregiver, generating, using a machine learning model, an event description based on video data from the patient room, and recording the description with annotations to the electronic medical record of the patient is described.

Abstract: Systems for monitoring respiration are described. One system receives spatiotemporal data from a sensor array worn by a patient. The spatiotemporal data includes spatial and temporal components. The system feeds the spatiotemporal data into a machine learning model. The system characterizes the respiration based on an output of the machine learning model. Another system identifies one or more edges on a wearable article, and tracks a frequency of motion of the one or more edges on the wearable device to determine the respiration rate.

Abstract: A machine comprising a rotor having: an inner member; an outer member encircling the inner member; and a groove in one of the inner member and the outer member. The groove has a first side wall, a second side wall and a base. A split ring seal is accommodated in the groove and contacts a surface of the other of the inner member and the outer member The first side wall has a plurality of open radial first channels and the second side wall has a plurality of open radial second channels.

Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.

Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.

Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.

Abstract: The present invention provides primers and probes to be used in a method of enhancing hybridization of a probe to a target nucleotide sequence when the target sequence is capable of forming intramolecular secondary structures that interfere with hybridization of the probe to the target sequence. In particular, the invention includes a primer for amplifying a target nucleotide sequence, wherein at least a portion of the target nucleotide sequence can form an intramolecular secondary structure. The primer of the invention includes a primer nucleotide sequence complementary to a portion of the target nucleotide sequence that does not form a secondary structure, and a blocking sequence substantially complementary to at least a portion of the secondary structure-forming region of the amplified target nucleotide sequence, wherein the blocking sequence hybridizes to a portion of the secondary structure-forming region of the amplified target nucleotide sequence and blocks the formation of the secondary structure.

Abstract: Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention.

Abstract: The present invention provides methods, compositions and systems for the specific and selective detection of multiple single nucleotide polymorphisms (SNPs) from genomic DNA. Importantly, the inventive systems and methods eliminate the need for costly, time- and labor-intensive gene amplification that is generally carried out prior to SNP detection. Also provided are kits useful to perform the inventive methods.

Abstract: Methods for preparing samples for use in assays are described. The methods use polyethylene glycol and magnetic particles and are conducted with minimal salt concentrations. The methods are useful for preparing samples such as blood samples for use in hybridization assays such as bDNA assays, immunoassays and PCR. Optimal process conditions that allow for highly sensitive assays are also described.

Abstract: A method for detecting the presence or absence of a genetic variation at a polymorphic site in a nucleic acid analyte in a sample is provided. The method comprises a series of steps used to form captured wild type complexes and captured variant complexes that are detected and counted. The method is carried out using first and second differential hybridization probes, first and second capture probes, and first and second solid substrates, each having a detectable signal. The invention also provides for kits for carrying out the assay.

Abstract: The present invention provides primers and probes to be used in a method of enhancing hybridization of a probe to a target nucleotide sequence when the target sequence is capable of forming intramolecular secondary structures that interfere with hybridization of the probe to the target sequence. In particular, the invention includes a primer for amplifying a target nucleotide sequence, wherein at least a portion of the target nucleotide sequence can form an intramolecular secondary structure. The primer of the invention includes a primer nucleotide sequence complementary to a portion of the target nucleotide sequence that does not form a secondary structure, and a blocking sequence substantially complementary to at least a portion of the secondary structure-forming region of the amplified target nucleotide sequence, wherein the blocking sequence hybridizes to a portion of the secondary structure-forming region of the amplified target nucleotide sequence and blocks the formation of the secondary structure.

Abstract: Novel binding assay techniques have been developed which improve accuracy and sensitivity via accounting for interfering factors. They rely on use, in a simultaneous incubation, of two or more different labels, some of which are used primarily to detect analyte, and others to detect interfering substances originating in the sample. The mathematical relationships between the labels allow corrections that lead to more accurate and sensitive determination of the presence and concentration of the analyte.

Abstract: A vibration control apparatus (20) and method for a calender (18) for controlling vibration between two or more rolls (ex. 22, 24) which controls vibration induced thickness variations in a medium (27) exiting from the nip. The apparatus (20) includes a frame (19), a first and second rolls (22, 24) mounted relative to the frame (19), and a force generator (32), such as an electromechanical active actuator, servo-hydraulic actuator, controllable semi-active damper, Active Vibration Absorber (AVA), or Adaptive Tuned Vibration Absorber (ATVA), provides cancelling forces to control vibration between the first and second roll (22, 24) thereby, controlling such vibration induced thickness variations in the medium (27). Preferably, the apparatus (20) includes at least one sensor (ex.

Abstract: A device for making electrical connection to a reciprocating element, such as to a voice coil of an actuator. An electrical flow path utilizing the helical centering springs as a primary element in conducting current ensures reliable current flow to a reciprocating element and avoids high-speed flexing of brittle wires. Hard-wired connections are utilized only between stationary elements. A second double-coil actuator embodiment employs a coaxial, substantially co-extensive pair of springs as the input and return current flow paths for each actuator.

Abstract: An ultrasonic wave generator comprising a semiconductor superlattice with a periodic variation in its space charge and a far infrared laser for applying a transient electric field to the superlattice transverse to the direction of its periodic variation. The ultrasonic wave produced has a wavelength of the period of the superlattice which can result in 100 gigahertz ultrasonic waves. Structure is included for guiding these waves into an acoustic system.