Abstract: Methods of addressing a biomolecule to a selectively addressable electrode are described. A permeation layer overlying a plurality of selectively addressable electrodes is provided. The permeation layer includes a reactive group that is adapted to bond to a biomolecule and that requires activation through a chemical transformation before bonding to the biomolecule. At least one selectively addressable electrode is biased such that a pH change occurs in an overlying solution of the at least one selectively addressable electrode. The reactive group in a portion of the permeation layer above the at least one selectively addressable electrode is then chemically transformed to an activated reactive group as a result of the pH change. A biomolecule is then bound to the permeation layer overlying the at least one selectively addressable electrode through the activated reactive group.

Abstract: Methods of addressing a biomolecule to a selectively addressable electrode are described. A permeation layer overlying a plurality of selectively addressable electrodes is provided. The permeation layer includes a reactive group that is adapted to bond to a biomolecule and that requires activation through a chemical transformation before bonding to the biomolecule. At least one selectively addressable electrode is biased such that a pH change occurs in an overlying solution of the at least one selectively addressable electrode. The reactive group in a portion of the permeation layer above the at least one selectively addressable electrode is then chemically transformed to an activated reactive group as a result of the pH change. A biomolecule is then bound to the permeation layer overlying the at least one selectively addressable electrode through the activated reactive group.

Abstract: A load lifting and supporting device for leveling beams and other adjustable compressive load applications. The load lifting and supporting device includes a housing with opposite ends, a longitudinal axis extending between the ends, a threaded bore extending therethrough along the longitudinal axis, and an outer surface. A pair of opposed extension members each have a threaded portion and a head portion. The threaded portions are threadedly received in the threaded bore of the housing and are extendible therefrom.

Abstract: Microreaction molds and methods of molding very thin films onto substrate surfaces are provided. The molds and molding methods allow for consistency and uniformity in the thicknesses of the films that are applied to the substrate surfaces. The molds may be single composite, such as etched silica, or multicomposite, such as quartz/metal. The molds may further comprise an adjustable molding cavity. The molds of this invention are particularly applicable to generating thin polymeric films onto microchip substrates.

Abstract: A load lifting and supporting device for leveling beams and other adjustable compressive load applications. The load lifting and supporting device includes a housing with opposite ends, a longitudinal axis extending between the ends, a threaded bore extending therethrough along the longitudinal axis, and an outer surface. A pair of opposed extension members each have a threaded portion and a head portion. The threaded portions are threadedly received in the threaded bore of the housing and are extendible therefrom.

Abstract: Methods are provided for laser induced fluorescence intensity feedback and control during laser angioplasty. In a first aspect of the invention, a catheter including an eccentric guidewire lumen and at least one optical fiber is positioned relative to an obstruction in a blood vessel by rotating the catheter and monitoring the fluorescence intensity. When the fluorescence intensity has a maximum value, the optical fiber is aligned with the obstruction. In another aspect of the invention, fluorescence intensity feedback is used to determine when a laser ablation device has crossed an occlusion. An abrupt drop in fluorescence intensity indicates that the ablation device has crossed the occlusion. In a further aspect of the invention, fluorescence intensity feedback is used to determine the effectiveness of fluid flushing in a blood vessel.

Abstract: A continuous process for casting a molten metal oxide such as an aluminous oxide and more particularly an alumina-zirconia eutectic composition that is subsequently crushed to produce an abrasive is provided wherein two thin metal belts are brought into face-to-face relation and the molten oxide is poured into the nip between the belts as they come into face-to-face relation. The material that is being solidified maintains the belts slightly spaced apart on the order of some small fraction of an inch (e.g. 1/16) and the back surface of the belt is flooded with copious quantities of cooling fluid (e.g. water) to maintain the belts below red heat. The belts are held in closely spaced relation for a sufficient time to permit the abrasive to be cooled below red heat. The belts are then separated and the abrasive is discharged from between the belts.

Abstract: Aluminum titanate is disclosed as an additive in coatings for magnetic recording media.

Abstract: Abrasive grits are prepared from molten oxide melt by pouring molten abrasive composition between plurality of spaced plates, made of heat resistant material such as graphite or metal to protect surface of molten abrasive from atmosphere and achieve rapid cooling. Abrasive is then comminuted by known methods to the desired grit sizes.

Abstract: An automatic progressively or continuously operative mold assembly for chilling a material which melts in excess of 1700.degree. C and forming quickly a fine crystalline solid material therefrom by depositing said material in a molten state in the relatively thin spaces between a plurality of relatively thick heat sink plates maintained tightly contiguous as they are moved sequentially through and beyond a first mold filling or discharging station, and then moved very rapidly sequentially through a second mold emptying or discharging station in which the relatively thick heat sink plates are maintained spaced apart to discharge therefrom the fine crystalline solid material adhered thereto.

Abstract: A molten magnesia is air quenched to provide a very large proportion of solid free flowing spheres of fused magnesia, a large percentage of which are smaller than about 35 Tyler mesh, which may be used directly in electrical resistor units without the necessity of crushing and calcining while the larger sized spheres may be crushed if desired and can be used with the uncrushed spheres without being calcined. The method may employ sea water magnesite or any other source of raw material having a high magnesia content that is cheap and readily available, the product being improved and more easily fused by the addition of small amounts of alumina, silica and calcia to the magnesite as it is being fed to the fusion furnace.