Patents by Inventor John J. Thaden

John J. Thaden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pulse Stable Tracer Methods for Detection of Short-Chain Fatty Acids
    Publication number: 20210003589
    Abstract: Provided herein are methods for determining a metabolic rate for at least one endogenous short-chain fatty acid in a subject, for diagnosing a pulmonary disease in a subject and for diagnosing a neurological disorder in a subject. Generally in the methods stable isotope labeled short-chain fatty acid are pulsed and metabolic rates are calculated in a first baseline blood sample and in a series of second blood samples obtained at intervals. The metabolic rates provide information about fatty acid metabolism and production.
    Type: Application
    Filed: February 8, 2019
    Publication date: January 7, 2021
    Applicant: Texas A&M University
    Inventors: Nicolaas E. Deutz, Marielle P. Engelen, Gabrielle A. Ten Have, John J. Thaden
  • Methods for measuring fat digestibility and uses thereof
    Patent number: 10175245
    Abstract: The present invention provides methods for continuous measurement of triglyceride digestibility during a meal. A stable isotope labeled triglyceride and a free fatty acid tracer are added to the meal. The ratio between a ratio of isotope labeled fatty acid produced after digestion to free fatty acid tracer represents the percentage of digestion of triglycerides by lipase from the pancreas.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: January 8, 2019
    Inventors: Nicolaas E. Deutz, Marielle P. Engelen, Guinur Com, John J. Thaden
  • Methods for Measuring Fat Digestibility and Uses Thereof
    Publication number: 20150072366
    Abstract: The present invention provides methods for continuous measurement of triglyceride digestibility during a meal. A stable isotope labeled triglyceride and a free fatty acid tracer are added to the meal. The ratio between a ratio of isotope labeled fatty acid produced after digestion to free fatty acid tracer represents the percentage of digestion of triglycerides by lipase from the pancreas.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Nicolaas E. Deutz, Marielle P. Engelen, Guinur Com, John J. Thaden
  • Methods of measuring protein and/or fat digestibility and uses thereof
    Patent number: 8906640
    Abstract: The present invention provides methods for continuous measurement of protein and/or triglyceride digestibility during a meal. Stable isotope of 15N-spirulina protein and 2H5-phenylalanine was added to the nutritional supplement. Protein digestibility is calculated by measuring the ratio [15N]PHE to [2H5]PHE in plasma and the nutrition. In another embodiment, [1,1,1-13C3]tripalmitin and [2,2-2H2]palmitic acid were added to the meal. The ratio between [1-13C]palmitic acid/[2,2-2H2]palmitic acid will represent the percentage digestion of triglycerides by lipase from the pancreas.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: December 9, 2014
    Inventors: Nicolaas E Deutz, Marielle P Engelen, Gulnur Com, John J Thaden
  • Methods of Measuring Protein and/or Fat Digestibility and Uses Thereof
    Publication number: 20140087407
    Abstract: The present invention provides methods for continuous measurement of protein and/or triglyceride digestibility during a meal. Stable isotope of 15N-spirulina protein and 2H5-phenylalanine was added to the nutritional supplement. Protein digestibility is calculated by measuring the ratio [15N]PHE to [2H5]PHE in plasma and the nutrition. In another embodiment, [1,1,1-13C3]tripalmitin and [2,2-2H2]palmitic acid were added to the meal. The ratio between [1-13C]palmitic acid/[2,2-2H2]palmitic acid will represent the percentage digestion of triglycerides by lipase from the pancreas.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 27, 2014
    Inventors: Nicolaas E. Deutz, Marielle P. Engelen, Gulnur Com, John J. Thaden