Patents by Inventor John J. V. Duncia

John J. V. Duncia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-adamant-1-y1-N1-[4-chlorobenzothiazol-2-y1] urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent
    Patent number: 6214851
    Abstract: This invention relates generally to N-adamant-1-yl-N′-[4-chlorobenzothiazol-2-yl] urea, pharmaceutical compositions comprising the same, and methods of using the same in the treatment of inflammation and as an anticancer radiosensitizing agent.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: April 10, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: John J. V. Duncia, Daniel S. Gardner, IV, Joseph B Santella, III
  • Boronic acid and ester inhibitors of thrombin
    Patent number: 5563127
    Abstract: Novel boronic acid and ester and carboxyl-modified amino acid compounds of the Formula I, which are inhibitors of trypsin-like enzymes, are disclosed :R.sup.1 --Z--CHR.sup.2 --A,where R.sup.1, Z, R.sup.2 and A are defined within.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: October 8, 1996
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Eugene C. Amparo, William H. Miller, Gregory J. Pacofsky, John Wityak, Patricia C. Weber, John J. V. Duncia, Joseph B. Santella, III
  • Imidazole 5-position substituted angiotensin II antagonists
    Patent number: 5545651
    Abstract: Novel substituted imidazoles of Formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: August 13, 1996
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: John J. V. Duncia, Carol L. Ensinger, Richard E. Olson, Mimi L. Quan, Joseph B. Santella, III, Mary K. Vanatten
  • Imidazole 5-position substituted angiotensin II antagonists
    Patent number: 5395844
    Abstract: Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: ##STR1## These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)me thyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbonyl]-4-ethyl-2-propyl-1H-imidazole, are useful as antihypertensive agents.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: March 7, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: John J. V. Duncia, Carol L. Ensinger, Richard E. Olson, Mimi L. Quan, Joseph B. Santella, III, Mary K. Vanatten
  • Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
    Patent number: 5376666
    Abstract: Novel heterocycle substituted azocycloalkane benzylimidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: December 27, 1994
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventor: John J. V. Duncia
  • Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
    Patent number: 5332820
    Abstract: Novel substituted dibenzobicyclo[2.2.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: July 26, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: John J. V. Duncia
  • Treatment of central nervous disorders with imidazole compounds
    Patent number: 5179113
    Abstract: Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamidomethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically suitable salts are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: January 12, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor J. De Noble, John J. V. Duncia, Pancras C. B. Wong
  • Method and composition for preventing NSAID-induced renal failure
    Patent number: 5155118
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: October 13, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of hypertension with angiotensin II blocking imidazoles
    Patent number: 5153197
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: October 6, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia
  • Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists
    Patent number: 5140037
    Abstract: Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxy methyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imi dazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.
    Type: Grant
    Filed: March 20, 1990
    Date of Patent: August 18, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor J. DeNoble, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of central nervous system disorders with benzimidazole angiotensin-II receptor antagonists
    Patent number: 5137906
    Abstract: Substituted benzimidazoles such as 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-chlorobenzimidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.
    Type: Grant
    Filed: March 20, 1990
    Date of Patent: August 11, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor J. De Noble, John J. V. Duncia, Pancras C. B. Wong
  • Angiotensin II receptor blocking imidazoles
    Patent number: 5138069
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: August 11, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles
    Patent number: 5128355
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: July 7, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia
  • Substituted 1,2,4-triazole angiotensin II antagonists
    Patent number: 5093346
    Abstract: Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: March 3, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Gregory J. Wells
  • Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
    Patent number: 5091390
    Abstract: Provided are 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AII type-2 receptors in the central nervous system.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: February 25, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, Andrew T. Chiu, John J. V. Duncia, Petrus B. M. W. M. Timmermans, Ruth R. Wexler
  • Substituted pyrrole angiotensin II antagonists
    Patent number: 5043349
    Abstract: Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: August 27, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Carini, David J., John J. V. Duncia, Gregory J. Wells
  • Treatment of hypertension with 1,2,4-angiotensin II antagonists
    Patent number: 5015651
    Abstract: Substituted pyrroles, pyrazoles and traizoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: May 14, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Gregory J. Wells
  • Combination .beta.-blocking/angiotensin II blocking antihypertensives
    Patent number: 4916129
    Abstract: Imidazole compounds such as ##STR1## which have angiotensin II antagonizing properties as well as .beta.-adrenoceptor antagonizing properties are useful as antihypertensives and for treatment of congestive heart failure.
    Type: Grant
    Filed: January 19, 1989
    Date of Patent: April 10, 1990
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia
  • Tetrazole intermediates to antihypertensive compounds
    Patent number: 4870186
    Abstract: Tetrazole intermediates useful to prepare antihypertensive compounds described in coassigned application U.S. Ser. No. 884,920, filed July 11, 1986, are described, these tetrazoles have the formula: ##STR1## wherein X.sup.1 and X.sup.2 are as described in the specification.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: September 26, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Paul E. Aldrich, John J. V. Duncia, Michael E. Pierce