Patents by Inventor John J. Venit

John J. Venit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
    Patent number: 6248882
    Abstract: The glycinamide of the formula is reacted with the dioxolane of the formula wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula Treating the dioxolane of formula III under aqueous refluxing conditions followed by exchanging the dioxolane acetal with a dimethoxy acetal and introduction of the methyl ester gives (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester which is an intermediate in the preparation of the dual inhibitor [4S-[4&agr;(R*),7&agr;, 10a&bgr;]]-)octahydro-4-[(2-mercapto-1-oxo-3-phenylpropy)-amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid. Also disclosed are storage stable salts of (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: June 19, 2001
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Jollie D. Godfrey, Jr., David R. Kronenthal, Mark D. Schwinden, Sushil K. Srivastava, Keith Ramig, John J. Venit, Paul A. Jass, Saibaba Racha, John L. Dillon, Jr., Nachimuthu Soundararajan, Gerald L. Powers, Atul S. Kotnis
  • Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides
    Patent number: 6162913
    Abstract: N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: December 19, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Jerome L. Moniot, Sushil K. Srivastava, William J. Winter, John J. Venit, Shankar Swaminathan, Keith Ramig, Paul A. Jass, Mark D. Schwinden, John L. Dillon, Jr., Saibaba Racha, James Simpson, Chien-Kuang Chen, Shawn K. Pack
  • Stereoselective reductive amination of ketones
    Patent number: 6140088
    Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: October 31, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Hanson, Mary Jo Donovan, Steven Goldberg, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, Laszlo J. Szarka, John J. Venit
  • 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: H1737
    Abstract: A method is provided for preparing intermediates for 7-oxabicycloheptane carboxylic acid intermediates of the structures ##STR1## wherein R is alkyl, aryl, arylalkyl or cycloalkyl; R.sup.1 is alkyl, arylalkyl or cycloalkyl; R.sup.2 is aryl or arylalkyl; and of the structure ##STR2## where R and R.sup.1 are as defined above, which may be used in making the final anti-thrombotic--anti-vasospastic compounds.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: June 2, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shankar Swaminathan, Philip M. Sher, Ambarish Singh, Wen-Sen Li, John J. Venit