Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Examples described herein relate to an accelerator that includes an interface and circuitry coupled to the interface. In some examples, the circuitry is configured to access compressed data, decompress the compressed data, and output the decompressed data based on a call to an application programming interface (API). In some examples, based on a first call to the API having first values, the circuitry is to decompress at least a subset of the data and output at least one strict subset of the decompressed data. In some examples, based on a second call to the API having second values, the circuitry is to decompress an entirety of the data and output the decompressed data.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: A light polymerizable composition for use in the additive manufacturing of medical devices may include a first photo-initiator and a second photo-initiator. The first photo-initiator activates to initiate curing of the composition when exposed to light of a first wavelength in an additive manufacturing device and the second photo-initiator limits the transmission of the light of the first wavelength that activates the first photo-initiator in the additive manufacturing device. The second photo-initiator is activated to further cure the composition when exposed to a light of a second wavelength different from the first wavelength by activating the second photo-initiator to produce free radicals at a higher rate when exposed to the light of the second wavelength than when exposed to the light of the first wavelength.

Abstract: Methods, systems, and products for subscribing for application messages in a multicast messaging environment as disclosed that include: requesting, by a message receiving device, a stream administration server to initialize a message subscription for application messages from a message sending device; receiving, in the message receiving device from the stream administration server, a data communications endpoint of a multicast message stream from the message sending device; beginning to listen, by the message receiving device, for the application messages at the data communications endpoint; and notifying, by the message receiving device after beginning to listen for the application messages, the message sending device to publish the application messages at the data communications endpoint.

Abstract: Methods, systems, and products are disclosed for terminating an application message subscription that include: receiving, by messaging middleware of a subscribing client device, application messages having one or more message topics on one or more message streams from one or more message transmitting devices; receiving, by the messaging middleware from a stream administration server, a subscription termination message specifying a particular message topic for application messages that the subscription client device is no longer authorized to receive; and ceasing, by the messaging middleware, to provide the received application messages having the particular message topic to an application on the subscribing client device, including providing the received application messages having other message topics to the application.

Abstract: Methods, systems, and products are disclosed for application message subscription tracking in a high speed, low latency data communications environment that includes: receiving, by a stream administration server from a subscribing client device, a subscription initiation request, the subscription initiation request specifying a message topic, the message topic specifying application messages for transmission to the subscribing client device from a message transmitting device; brokering, by the stream administration server, establishment of a message stream that provides the application messages for the specified message topic from the message transmitting device to the subscribing client device; and updating, by the stream administration server, a client subscription repository for monitoring application message subscriptions in dependence upon the subscription initiation request.

Abstract: Methods, apparatus, and products are disclosed for dispatching a message request to a service provider in a messaging environment that include: establishing, on a message administration device, a plurality of lookup tables for mapping request types to service providers; receiving, in the message administration device from a message requesting device, a message request of one of the request types; identifying, by the message administration device, the service provider for processing the message request in dependence upon the message request and the plurality of lookup tables; and providing, by the message administration device, the message request to the identified service provider.

Abstract: Methods, systems, and products for subscribing for application messages in a multicast messaging environment as disclosed that include: requesting, by a message receiving device, a stream administration server to initialize a message subscription for application messages from a message sending device; receiving, in the message receiving device from the stream administration server, a data communications endpoint of a multicast message stream from the message sending device; beginning to listen, by the message receiving device, for the application messages at the data communications endpoint; and notifying, by the message receiving device after beginning to listen for the application messages, the message sending device to publish the application messages at the data communications endpoint.

Abstract: A system and method for wafer level global bitmap characterization include determining chip level defect data bitmaps from a semiconductor wafer, and consolidating the chip level defect data bitmaps into a global wafer level bitmap that characterizes substantially the entire wafer failure configuration. The global wafer level bitmap is then analyzed and compared with other global wafer level bitmaps to develop correlations thereamong and develop global wafer level bitmap definitions for conducting at least one of wafer-to-wafer, boat-to-boat, and lot-to-lot process analysis based upon the global wafer level bitmap definitions.

Abstract: A method for determination of tunnel oxide weakness is provided. A tunnel oxide layer is formed on a semiconductor wafer. At least one poly gate is formed on the tunnel oxide layer in a flash memory region of the semiconductor wafer. At least one poly island, which is substantially larger than the poly gate, is formed on the tunnel oxide layer in a voltage contrast cell region of the semiconductor wafer. The poly island and the tunnel oxide layer therebeneath form a voltage contrast tunnel oxide cell. A voltage contrast measurement is performed on the voltage contrast tunnel oxide cell. The voltage contrast measurement is then compared with prior such voltage contrast measurements on other such voltage contrast tunnel oxide cells. The tunnel oxide weakness of the tunnel oxide layer is then determined from the voltage contrast measurement comparisons.

Abstract: A method and system of processing tester information of a system under test is provided. Data of a tested characteristic of the system under test is generated. A distribution curve is extracted from the data. A signature of the distribution curve is determined, and a map of the signature on a depiction of the system under test is presented. The distribution curve also can be categorized in a plurality of bins, and bitmaps are generated for the sections in each of the plurality of bins. Systematic signatures are determined from the bitmaps in the block, and the signatures are correlated with the locations on the system under test.

Abstract: For electrically determining the level of misalignment of floating gate structures closest to a gate stack bending point in an array of flash memory cells, a plurality of test flash memory cells are formed with each test flash memory cell having a respective floating gate structure designed to be disposed a respective displacement distance from a respective gate stack bending point. An erase operation is performed for each of the test flash memory cells by biasing the test flash memory cells with voltages from a plurality of voltage sources. Each of the test flash memory cells are then biased with test voltages from the plurality of voltage sources. A respective current meter then measures a respective amount of current flowing through each of the test flash memory cells when biased with the test voltages. The level of misalignment is determined depending on which of the test flash memory cells conducts a current level that is greater than a threshold current level when biased with the test voltages.

Abstract: An improved method for fabricating a NAND-type memory cell structure. The present invention forgoes providing a contact mask implantation process prior to deposition of a metal barrier layer, which is a typical order of processing the NAND-type memory cell. Instead, in the present invention, the metal barrier layer is deposited on a core area of the NAND-type memory cell prior to contact mask implantation. Thereafter, the contact mask implantation process is performed on the structure in a conventional manner.

Abstract: A method and apparatus for an integrated circuit on a semiconductor substrate having good metal contact points. A first polysilicon layer is formed onto the substrate, and is etched to provide contact regions to the substrate. An ONO layer is formed onto the first polysilicon layer. A second polysilicon layer is formed onto the ONO layer, and a metal silicide layer is formed onto the second polysilicon layer. The second polysilicon layer and the metal silicide layer are etched at particular locations in order to form contact regions to the first polysilicon layer and to the substrate. A selective layer is formed onto the second polysilicon layer, the selective layer being etch selective with respect to the first polysilicon layer. An interlayer dielectric is formed onto the selective layer. A first etching is performed to provide a contact path through the interlayer dielectric, and then a second etching is performed to provide a contact path through the selective layer.

Abstract: A method and apparatus for an integrated circuit on a semiconductor substrate having good metal contact points. A first polysilicon layer is formed onto the substrate, and is etched to provide contact regions to the substrate. An ONO layer is formed onto the first polysilicon layer. A second polysilicon layer is formed onto the ONO layer, and a metal silicide layer is formed onto the second polysilicon layer. The second polysilicon layer and the metal silicide layer are etched at particular locations in order to form contact regions to the first polysilicon layer and to the substrate. A selective layer is formed onto the second polysilicon layer, the selective layer being etch selective with respect to the first polysilicon layer. An interlayer dielectric is formed onto the selective layer. A first etching is performed to provide a contact path through the interlayer dielectric, and then a second etching is performed to provide a contact path through the selective layer.

Abstract: An apparatus for effecting precise slicing and division of various sheet-like food members, such as cake, pizza and the like. The apparatus includes a housing including a manually manipulatable drive gear positioned medially thereof, with the drive gear rotatable by use of a rotatable incrementally divided handle projecting orthogonally and upwardly relative to the housing, with a plurality of reciprocatable gear racks directed exteriorly of the housing through each opposed side thereof in cooperation with the gear to adjust spacing of cutting wheels, each mounted at a remote terminal end of each gear rack.

Abstract: A process for removing contaminants from soil or aquifers. The process uses wick drains which include an outer filter medium supported by a rigid inner perforate member. The wick drains are inserted into the contaminated soil or aquifer, water is injected into one or more of the wick drains, and water and contaminants are removed from one or more wick drains. The wick drains are inserted by placing the wick drains in mandrels and driving them into the soil or aquifers, in a manner similar to that in which piles are driven, at a rate of up to about 8,000 to 10,000 linear feet per day.