Abstract: In some embodiments, there is provide a method of analysing a bone fracture, comprising; stabilizing a bone having a fracture including a first support point located distal of the fracture and a second support point located proximal of the fracture; applying a force to an area of the bone having the fracture to cause a displacement of the fracture; imaging the bone during the application of force thereto; and comparing the image of the bone during the application of force to an image of the bone without the application of force to determine the state of the fracture.

Abstract: In some embodiments, there is provide a method of analysing a bone fracture, comprising; stabilizing a bone having a fracture including a first support point located distal of the fracture and a second support point located proximal of the fracture; applying a force to an area of the bone having the fracture to cause a displacement of the fracture; imaging the bone during the application of force thereto; and comparing the image of the bone during the application of force to an image of the bone without the application of force to determine the state of the fracture.

Abstract: In some embodiments, there is provide a method of analysing a bone fracture, comprising; stabilizing a bone having a fracture including a first support point located distal of the fracture and a second support point located proximal of the fracture; applying a force to an area of the bone having the fracture to cause a displacement of the fracture; imaging the bone during the application of force thereto; and comparing the image of the bone during the application of force to an image of the bone without the application of force to determine the state of the fracture.

Abstract: Advances in our understanding of the cellular mechanisms underlying skeletal regeneration have not been effectively translated in vivo treatment because non-invasive monitoring of bone fracture healing is limited to imaging technology (i.e., for example, x-rays) that cannot be quantified and are subjectively interpreted. The method disclosed herein assesses rates of hip fracture healing using a strain gauge device implanted into a standard orthopedic implant. It has been demonstrated that such a device can measure differences between intact and partially osteotomized fracture models (p<0.05) and that the device can distinguish between stable and unstable fracture patterns in completely osteotomized models across a physiologic range of loads. Such devices are compatible with in vivo bone fracture healing methods, wherein the device is placed onto an orthopedic implant and the strain data is transmitted on a real time basis, thereby providing a non-invasive quantification of bone fracture repair rates.

Abstract: The present invention is related to the field of cartilage physiology, repair, and regeneration. In particular, the invention contemplates a treatment for bone healing disorders, especially those related to the articular joints and bone, by upregulating chondrocyte proliferation. For example, inhibition of cysteinyl leukotriene activity on chondrocytes by using cysteinyl leukotriene-1 receptor antagonists may be useful in preventing and treating bone healing disorders.